Protein Description

Gene Symbol ZDHHC7
Entrez ID 55625
Uniprot ID Q9NXF8
Description zinc finger, DHHC-type containing 7
Chromosomal Location chr16: 84,974,181-85,011,535
Ontology GO ID GO Term Definition Evidence

BP

GO:0018230

peptidyl-L-cysteine S-palmitoylation

The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine.

IMP

BP

GO:0018345

protein palmitoylation

The covalent attachment of a palmitoyl group to a protein.

IDA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0043231

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

IDA

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IEA

MF

GO:0016409

palmitoyltransferase activity

Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.

IDA

MF

GO:0019706

protein-cysteine S-palmitoyltransferase activity

Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule.

IEA

Domain ID Description

IPR001594

Palmitoyltransferase, DHHC domain

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

fallopian tube

glandular cells

kidney

cells in tubules

ovary

follicle cells

prostate

glandular cells

rectum

glandular cells

seminal vesicle

glandular cells

small intestine

glandular cells

stomach

glandular cells

tonsil

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

APP

351

P05067

0.56

CKM

1158

P06732

0.63

PBX2

5089

P40425

0.63

REEP5

7905

Q00765

0.63

MARCH6

10299

O60337

0.63

TMEM186

25880

Q96B77

0.63

NDFIP1

80762

Q9BT67

0.63

TMEM259

91304

Q4ZIN3

0.63

ESR1

2099

P03372

0.63

MOV10

4343

Q9HCE1

0.63

NXF1

10482

Q9UBU9

0.63