PCOSBase

Protein Description

Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006468	protein phosphorylation	The process of introducing a phosphate group on to a protein.	IBA
BP	GO:0030500	regulation of bone mineralization	Any process that modulates the frequency, rate or extent of bone mineralization.	IBA
BP	GO:0050790	regulation of catalytic activity	Any process that modulates the activity of an enzyme.	IEA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IBA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA
MF	GO:0004674	protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.	IBA
MF	GO:0005524	ATP binding	Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.	IEA
MF	GO:0019208	phosphatase regulator activity	Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.	IBA

Domain ID	Description
IPR000719	Protein kinase domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain
IPR026105	BMP-2-inducible protein kinase
IPR028182	BMP-2-inducible protein kinase, C-terminal

Pathway ID	Pathway Term	Pathway Source
hsa05202	Transcriptional misregulation in cancer	KEGG

Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
bone marrow	hematopoietic cells
bronchus	respiratory epithelial cells
colon	glandular cells
duodenum	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
kidney	cells in glomeruli
lung	macrophages
lung	pneumocytes
nasopharynx	respiratory epithelial cells
parathyroid gland	glandular cells
placenta	decidual cells
placenta	trophoblastic cells
rectum	glandular cells
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
spleen	cells in red pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells

Pubmed ID	Author	Year	Title
22617121	Ouandaogo et al.	2012	Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation
22789864	Yan et al.	2012	Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
MBP	4155	P02686	0.62
ABL1	25	P00519	0.63
LIMS1	3987	P48059	0.63
TERF1	7013	P54274	0.63
TERF2	7014	Q15554	0.63
XPO1	7514	O14980	0.63
NUMB	8650	P49757	0.63
KDM5B	10765	Q9UGL1	0.63
SLC25A41	284427	Q8N5S1	0.63
CAPZA2	830	P47755	0.72
CDK2	1017	P24941	0.72
CLTB	1212	P09497	0.72
CLTC	1213	Q00610	0.72
DBN1	1627	Q16643	0.72
EPS15	2060	P42566	0.72
FLNA	2316	P21333	0.72
FN1	2335	P02751	0.72
GAK	2580	O14976	0.72
GBA	2629	P04062	0.72
MYH9	4627	P35579	0.72
PPP1CB	5500	P62140	0.72
PICALM	8301	Q13492	0.72
IQGAP1	8826	P46940	0.72
PDLIM7	9260	Q9NR12	0.72
SEC16A	9919	O15027	0.72
SYNPO	11346	Q8N3V7	0.72
LIMA1	51474	Q9UHB6	0.72
GTSE1	51512	Q9NYZ3	0.72
ANLN	54443	Q9NQW6	0.72
MYO19	80179	Q96H55	0.72
MYO18A	399687	Q92614	0.72
AP2M1	1173	Q96CW1	0.73