Protein Description

Gene Symbol TRPV6
Entrez ID 55503
Uniprot ID Q9H1D0
Description transient receptor potential cation channel, subfamily V, member 6
Chromosomal Location chr7: 142,871,203-142,885,762
Ontology GO ID GO Term Definition Evidence

BP

GO:0006816

calcium ion transport

The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IDA|NAS

BP

GO:0017158

regulation of calcium ion-dependent exocytosis

Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis.

NAS

BP

GO:0051592

response to calcium ion

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.

ISS

BP

GO:0055074

calcium ion homeostasis

Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.

ISS

BP

GO:0070588

calcium ion transmembrane transport

A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

IDA|TAS

BP

GO:1990035

calcium ion import into cell

The directed movement of calcium ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.

IDA|ISS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA|TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IDA|ISS|TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005262

calcium channel activity

Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

IDA|TAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005516

calmodulin binding

Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.

IDA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

Domain ID Description

IPR002110

Ankyrin repeat

IPR004729

Transient receptor potential channel

IPR005821

Ion transport domain

IPR008344

Transient receptor potential cation channel subfamily V member 5/6

IPR008345

Transient receptor potential channel, vanilloid 6

IPR020683

Ankyrin repeat-containing domain

IPR024862

Transient receptor potential cation channel subfamily V

Pathway ID Pathway Term Pathway Source

hsa04970

Salivary secretion

KEGG

hsa04978

Mineral absorption

KEGG

No diseases found.

Tissue Cell Type

placenta

decidual cells

soft tissue

chondrocytes

soft tissue

fibroblasts

Database Name

DisGeNET

Pubmed ID Author Year Title

21411543

Savaris et al.

2011

Progesterone Resistance in PCOS Endometrium: A Microarray Analysis in Clomiphene Citrate-Treated and Artificial Menstrual Cycles

Gene Symbol Entrez ID Uniprot ID Score

CALM2

805

P62158

0.62

CALM3

808

P62158

0.62

KRT40

125115

Q6A162

0.63

KRTAP10-5

386680

P60370

0.63

KRTAP10-8

386681

P60410

0.63

KRTAP10-3

386682

P60369

0.63

NOTCH2NL

388677

Q7Z3S9

0.63

TRPV6

55503

Q9H1D0

0.65

NEDD4

4734

P46934

0.68

MDFI

4188

Q99750

0.74

S100A10

6281

P60903

0.85

PRKCA

5578

P17252

0.58

PDE9A

5152

O76083

0.63

TRAF1

7185

Q13077

0.63

PNMA1

9240

Q8ND90

0.63

MID2

11043

Q9UJV3

0.63

CALB1

793

P05937

0.70

PTPN1

5770

P18031

0.94