| Gene Symbol | ARHGEF10L |
| Entrez ID | 55160 |
| Uniprot ID | Q9HCE6 |
| Description | Rho guanine nucleotide exchange factor 10 like |
| Chromosomal Location | chr1: 17,539,835-17,697,874 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0035023 |
regulation of Rho protein signal transduction |
Any process that modulates the frequency, rate or extent of Rho protein signal transduction. |
IEA |
|
BP |
GO:0043547 |
positive regulation of GTPase activity |
Any process that activates or increases the activity of a GTPase. |
IEA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IEA |
|
MF |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000219 |
Dbl homology (DH) domain |
|
IPR011993 |
PH domain-like |
|
IPR015943 |
WD40/YVTN repeat-like-containing domain |
|
IPR017986 |
WD40-repeat-containing domain |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
kidney |
cells in tubules |
|
lung |
macrophages |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
islets of Langerhans |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
SCN2A |
6326 |
Q99250 |
0.63 |
|
ANXA9 |
8416 |
O76027 |
0.63 |
|
NR4A1 |
3164 |
P22736 |
0.73 |
|
DRAP1 |
10589 |
Q14919 |
0.73 |