BP

GO:0001764

neuron migration

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.

ISS

BP

GO:0002098

tRNA wobble uridine modification

The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.

IBA

BP

GO:0006357

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|TAS

BP

GO:0006368

transcription elongation from RNA polymerase II promoter

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

TAS

BP

GO:0007417

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

ISS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

ISS

BP

GO:0043966

histone H3 acetylation

The modification of histone H3 by the addition of an acetyl group.

IDA

BP

GO:0043967

histone H4 acetylation

The modification of histone H4 by the addition of an acetyl group.

IDA

BP

GO:0045859

regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.

IEA

CC

GO:0000123

histone acetyltransferase complex

A protein complex that possesses histone acetyltransferase activity.

IDA

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0008023

transcription elongation factor complex

Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

IDA

CC

GO:0033588

Elongator holoenzyme complex

A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.

IDA

MF

GO:0000993

RNA polymerase II core binding

Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008607

phosphorylase kinase regulator activity

Modulation of the activity of the enzyme phosphorylase kinase.

IDA

MF

GO:0010484

H3 histone acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3.

IDA

MF

GO:0010485

H4 histone acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4.

IDA

MF

GO:0046872

metal ion binding

Interacting selectively and non-covalently with any metal ion.

IEA

MF

GO:0051536

iron-sulfur cluster binding

Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms.

IEA