Protein Description

Gene Symbol CSF3R
Entrez ID 1441
Uniprot ID Q99062
Description colony stimulating factor 3 receptor
Chromosomal Location chr1: 36,466,043-36,483,278
Ontology GO ID GO Term Definition Evidence

BP

GO:0006952

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

TAS

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NAS

BP

GO:0019221

cytokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IEA

BP

GO:0030593

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

IEA

BP

GO:0045637

regulation of myeloid cell differentiation

Any process that modulates the frequency, rate or extent of myeloid cell differentiation.

IEA

BP

GO:0097186

amelogenesis

The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

MF

GO:0004872

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

TAS

MF

GO:0004896

cytokine receptor activity

Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

IEA

Domain ID Description

IPR003529

Long hematopoietin receptor, Gp130 family 2, conserved site

IPR003961

Fibronectin type III

IPR007110

Immunoglobulin-like domain

IPR010457

Immunoglobulin C2-set-like, ligand-binding

IPR013783

Immunoglobulin-like fold

Pathway ID Pathway Term Pathway Source

hsa04060

Cytokine-cytokine receptor interaction

KEGG

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04630

Jak-STAT signaling pathway

KEGG

hsa04640

Hematopoietic cell lineage

KEGG

hsa05200

Pathways in cancer

KEGG

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

UMLS CUI UMLS Term

C0023481

Chronic Neutrophilic Leukemia

C0023518

Leukocytosis

Tissue Cell Type

placenta

trophoblastic cells

No databases found.

Pubmed ID Author Year Title

22904171

Kaur et al.

2012

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

Gene Symbol Entrez ID Uniprot ID Score

TYK2

7297

P29597

0.00

SOCS1

8651

O15524

0.00

SOCS2

8835

O14508

0.00

SOCS5

9655

O75159

0.00

SOCS7

30837

O14512

0.00

CSF3R

1441

Q99062

0.52

LCK

3932

P06239

0.52

PLA2G1B

5319

P04054

0.52

INPP5D

3635

Q92835

0.55

GSK3B

2932

P49841

0.63

FBXW7

55294

Q969H0

0.63

UBC

7316

P0CG48

0.68

CISH

1154

Q9NSE2

0.71

FZR1

51343

Q9UM11

0.72

WSB1

26118

Q9Y6I7

0.76

WSB2

55884

Q9NYS7

0.77

GRB2

2885

P62993

0.88

CBL

867

P22681

0.00

CBLC

23624

Q9ULV8

0.00

CSF3

1440

P09919

0.52

ELANE

1991

P08246

0.52

FTH1

2495

P02794

0.52

SOCS3

9021

O14543

0.52

JAK2

3717

O60674

0.55

PTPN11

5781

Q06124

0.65

STAT3

6774

P40763

0.70

LYN

4067

P07948

0.73

SYK

6850

P43405

0.73

JAK1

3716

P23458

0.74

HCK

3055

P08631

0.79

CSF2

1437

P04141

0.82

SHC1

6464

P29353

0.88