Gene Symbol | CSF3R |
Entrez ID | 1441 |
Uniprot ID | Q99062 |
Description | colony stimulating factor 3 receptor |
Chromosomal Location | chr1: 36,466,043-36,483,278 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006952 |
defense response |
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. |
TAS |
BP |
GO:0007155 |
cell adhesion |
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. |
IEA |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
NAS |
BP |
GO:0019221 |
cytokine-mediated signaling pathway |
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
IEA |
BP |
GO:0030593 |
neutrophil chemotaxis |
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding. |
IEA |
BP |
GO:0045637 |
regulation of myeloid cell differentiation |
Any process that modulates the frequency, rate or extent of myeloid cell differentiation. |
IEA |
BP |
GO:0097186 |
amelogenesis |
The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage. |
IEA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
IEA |
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
TAS |
CC |
GO:0005887 |
integral component of plasma membrane |
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
TAS |
MF |
GO:0004872 |
receptor activity |
Combining with an extracellular or intracellular messenger to initiate a change in cell activity. |
TAS |
MF |
GO:0004896 |
cytokine receptor activity |
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
IEA |
Domain ID | Description |
---|---|
IPR003529 |
Long hematopoietin receptor, Gp130 family 2, conserved site |
IPR003961 |
Fibronectin type III |
IPR007110 |
Immunoglobulin-like domain |
IPR010457 |
Immunoglobulin C2-set-like, ligand-binding |
IPR013783 |
Immunoglobulin-like fold |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04060 |
Cytokine-cytokine receptor interaction |
KEGG |
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
hsa04630 |
Jak-STAT signaling pathway |
KEGG |
hsa04640 |
Hematopoietic cell lineage |
KEGG |
hsa05200 |
Pathways in cancer |
KEGG |
WP3932 |
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0023481 |
Chronic Neutrophilic Leukemia |
C0023518 |
Leukocytosis |
Tissue | Cell Type |
---|---|
placenta |
trophoblastic cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22904171 |
Kaur et al. |
2012 |
Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
TYK2 |
7297 |
P29597 |
0.00 |
SOCS1 |
8651 |
O15524 |
0.00 |
SOCS2 |
8835 |
O14508 |
0.00 |
SOCS5 |
9655 |
O75159 |
0.00 |
SOCS7 |
30837 |
O14512 |
0.00 |
CSF3R |
1441 |
Q99062 |
0.52 |
LCK |
3932 |
P06239 |
0.52 |
PLA2G1B |
5319 |
P04054 |
0.52 |
INPP5D |
3635 |
Q92835 |
0.55 |
GSK3B |
2932 |
P49841 |
0.63 |
FBXW7 |
55294 |
Q969H0 |
0.63 |
UBC |
7316 |
P0CG48 |
0.68 |
CISH |
1154 |
Q9NSE2 |
0.71 |
FZR1 |
51343 |
Q9UM11 |
0.72 |
WSB1 |
26118 |
Q9Y6I7 |
0.76 |
WSB2 |
55884 |
Q9NYS7 |
0.77 |
GRB2 |
2885 |
P62993 |
0.88 |
CBL |
867 |
P22681 |
0.00 |
CBLC |
23624 |
Q9ULV8 |
0.00 |
CSF3 |
1440 |
P09919 |
0.52 |
ELANE |
1991 |
P08246 |
0.52 |
FTH1 |
2495 |
P02794 |
0.52 |
SOCS3 |
9021 |
O14543 |
0.52 |
JAK2 |
3717 |
O60674 |
0.55 |
PTPN11 |
5781 |
Q06124 |
0.65 |
STAT3 |
6774 |
P40763 |
0.70 |
LYN |
4067 |
P07948 |
0.73 |
SYK |
6850 |
P43405 |
0.73 |
JAK1 |
3716 |
P23458 |
0.74 |
HCK |
3055 |
P08631 |
0.79 |
CSF2 |
1437 |
P04141 |
0.82 |
SHC1 |
6464 |
P29353 |
0.88 |