BP

GO:0001934

positive regulation of protein phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

IMP

BP

GO:0006954

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

ISS

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

TAS

BP

GO:0007411

axon guidance

The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.

IEA

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

IMP

BP

GO:0008284

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

IMP

BP

GO:0008285

negative regulation of cell proliferation

Any process that stops, prevents or reduces the rate or extent of cell proliferation.

IEA

BP

GO:0008360

regulation of cell shape

Any process that modulates the surface configuration of a cell.

IMP

BP

GO:0018108

peptidyl-tyrosine phosphorylation

The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.

IDA

BP

GO:0019221

cytokine-mediated signaling pathway

A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

IMP

BP

GO:0021772

olfactory bulb development

The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.

IEA

BP

GO:0021879

forebrain neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.

IEA

BP

GO:0030097

hemopoiesis

The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.

IMP

BP

GO:0030224

monocyte differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.

TAS

BP

GO:0030225

macrophage differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.

TAS

BP

GO:0030316

osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

ISS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

ISS

BP

GO:0031529

ruffle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.

ISS

BP

GO:0036006

cellular response to macrophage colony-stimulating factor stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus.

IMP

BP

GO:0038145

macrophage colony-stimulating factor signaling pathway

A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

ISS

BP

GO:0042517

positive regulation of tyrosine phosphorylation of Stat3 protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.

ISS

BP

GO:0043066

negative regulation of apoptotic process

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

IEA

BP

GO:0045087

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

IEA

BP

GO:0045124

regulation of bone resorption

Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).

ISS

BP

GO:0045217

cell-cell junction maintenance

The maintenance of junctions between cells.

IMP

BP

GO:0046488

phosphatidylinositol metabolic process

The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

ISS

BP

GO:0046777

protein autophosphorylation

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

IDA

BP

GO:0048015

phosphatidylinositol-mediated signaling

A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

ISS

BP

GO:0060603

mammary gland duct morphogenesis

The process in which anatomical structures of the mammary ducts are generated and organized. Mammary ducts are epithelial tubes that transport milk.

TAS

BP

GO:0061098

positive regulation of protein tyrosine kinase activity

Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.

IMP

BP

GO:0070374

positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

ISS

BP

GO:0071345

cellular response to cytokine stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.

ISS

BP

GO:0071902

positive regulation of protein serine/threonine kinase activity

Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.

ISS

BP

GO:0090197

positive regulation of chemokine secretion

Any process that increases the rate, frequency or extent of chemokine secretion, the regulated release of chemokines from a cell.

IMP

BP

GO:2000147

positive regulation of cell motility

Any process that activates or increases the frequency, rate or extent of cell motility.

IMP

BP

GO:2000249

regulation of actin cytoskeleton reorganization

Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization.

ISS

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

IEA

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

TAS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

CC

GO:0009986

cell surface

The external part of the cell wall and/or plasma membrane.

ISS

CC

GO:1990682

CSF1-CSF1R complex

A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.

ISS

MF

GO:0005011

macrophage colony-stimulating factor receptor activity

Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

IMP|ISS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0019903

protein phosphatase binding

Interacting selectively and non-covalently with any protein phosphatase.

IEA

MF

GO:0019955

cytokine binding

Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.

IDA|ISS

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

ISS