| Gene Symbol | PGPEP1 |
| Entrez ID | 54858 |
| Uniprot ID | Q9NXJ5 |
| Description | pyroglutamyl-peptidase I |
| Chromosomal Location | chr19: 18,340,587-18,369,950 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006508 |
proteolysis |
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
IBA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IBA |
|
MF |
GO:0008234 |
cysteine-type peptidase activity |
Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
IEA |
|
MF |
GO:0016920 |
pyroglutamyl-peptidase activity |
Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000816 |
Peptidase C15, pyroglutamyl peptidase I |
|
IPR016125 |
Peptidase C15, pyroglutamyl peptidase I-like |
|
IPR029761 |
Pyroglutamyl peptidase I, metazoa |
|
IPR033693 |
Pyroglutamyl peptidase I, Glu active site |
|
IPR033694 |
Pyroglutamyl peptidase I, Cys active site |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
adipocytes |
|
bronchus |
respiratory epithelial cells |
|
caudate |
neuronal cells |
|
cerebral cortex |
neuronal cells |
|
cerebral cortex |
neuropil |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
nasopharynx |
respiratory epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
adipocytes |
|
soft tissue |
chondrocytes |
|
stomach |
glandular cells |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
GFER |
2671 |
P55789 |
0.63 |
|
GTF2I |
2969 |
P78347 |
0.63 |
|
HBA1 HBA2 |
3039 |
P69905 |
0.63 |
|
HBB |
3043 |
P68871 |
0.63 |
|
TNNT3 |
7140 |
P45378 |
0.63 |
|
TRIM11 |
81559 |
Q96F44 |
0.63 |
|
SELO |
83642 |
Q9BVL4 |
0.63 |