| Gene Symbol | CREBBP |
| Entrez ID | 1387 |
| Uniprot ID | Q92793 |
| Description | CREB binding protein |
| Chromosomal Location | chr16: 3,725,054-3,880,726 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
|
BP |
GO:0001666 |
response to hypoxia |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
TAS |
|
BP |
GO:0002223 |
stimulatory C-type lectin receptor signaling pathway |
Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation. |
TAS |
|
BP |
GO:0006355 |
regulation of transcription, DNA-templated |
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
IDA|TAS |
|
BP |
GO:0006367 |
transcription initiation from RNA polymerase II promoter |
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription. |
TAS |
|
BP |
GO:0006461 |
protein complex assembly |
The aggregation, arrangement and bonding together of a set of components to form a protein complex. |
TAS |
|
BP |
GO:0006473 |
protein acetylation |
The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. |
IDA |
|
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
NAS |
|
BP |
GO:0007219 |
Notch signaling pathway |
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
TAS |
|
BP |
GO:0008589 |
regulation of smoothened signaling pathway |
Any process that modulates the frequency, rate or extent of smoothened signaling. |
TAS |
|
BP |
GO:0016032 |
viral process |
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. |
IEA |
|
BP |
GO:0016573 |
histone acetylation |
The modification of a histone by the addition of an acetyl group. |
IDA |
|
BP |
GO:0018076 |
N-terminal peptidyl-lysine acetylation |
The acetylation of the N-terminal lysine of proteins. |
IDA |
|
BP |
GO:0032481 |
positive regulation of type I interferon production |
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. |
TAS |
|
BP |
GO:0034644 |
cellular response to UV |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. |
IDA |
|
BP |
GO:0042592 |
homeostatic process |
Any biological process involved in the maintenance of an internal steady state. |
NAS |
|
BP |
GO:0042733 |
embryonic digit morphogenesis |
The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe. |
TAS |
|
BP |
GO:0042981 |
regulation of apoptotic process |
Any process that modulates the occurrence or rate of cell death by apoptotic process. |
TAS |
|
BP |
GO:0044255 |
cellular lipid metabolic process |
The chemical reactions and pathways involving lipids, as carried out by individual cells. |
TAS |
|
BP |
GO:0045893 |
positive regulation of transcription, DNA-templated |
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
IDA|ISS |
|
BP |
GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IEA |
|
BP |
GO:0048511 |
rhythmic process |
Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. |
IEA |
|
BP |
GO:0061418 |
regulation of transcription from RNA polymerase II promoter in response to hypoxia |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus. |
TAS |
|
BP |
GO:1900034 |
regulation of cellular response to heat |
Any process that modulates the frequency, rate or extent of cellular response to heat. |
TAS |
|
BP |
GO:1904837 |
beta-catenin-TCF complex assembly |
The aggregation, arrangement and bonding together of a set of components to form a beta-catenin-TCF complex. |
TAS |
|
CC |
GO:0000123 |
histone acetyltransferase complex |
A protein complex that possesses histone acetyltransferase activity. |
IEA |
|
CC |
GO:0000790 |
nuclear chromatin |
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. |
IDA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IC|IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA|TAS |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0016604 |
nuclear body |
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
IDA |
|
MF |
GO:0000987 |
core promoter proximal region sequence-specific DNA binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon. |
IDA |
|
MF |
GO:0001078 |
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA |
|
MF |
GO:0001085 |
RNA polymerase II transcription factor binding |
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II. |
IPI |
|
MF |
GO:0001102 |
RNA polymerase II activating transcription factor binding |
Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription. |
TAS |
|
MF |
GO:0001105 |
RNA polymerase II transcription coactivator activity |
Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery. |
TAS |
|
MF |
GO:0001191 |
transcriptional repressor activity, RNA polymerase II transcription factor binding |
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
IDA |
|
MF |
GO:0002039 |
p53 binding |
Interacting selectively and non-covalently with one of the p53 family of proteins. |
IPI |
|
MF |
GO:0003682 |
chromatin binding |
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
IDA |
|
MF |
GO:0003684 |
damaged DNA binding |
Interacting selectively and non-covalently with damaged DNA. |
IDA |
|
MF |
GO:0003700 |
transcription factor activity, sequence-specific DNA binding |
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
TAS |
|
MF |
GO:0003713 |
transcription coactivator activity |
Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. |
IDA|IPI |
|
MF |
GO:0004402 |
histone acetyltransferase activity |
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
IDA |
|
MF |
GO:0004871 |
signal transducer activity |
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. |
TAS |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0008134 |
transcription factor binding |
Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
IPI |
|
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IEA |
|
MF |
GO:0016407 |
acetyltransferase activity |
Catalysis of the transfer of an acetyl group to an acceptor molecule. |
EXP|IDA |
|
MF |
GO:0034212 |
peptide N-acetyltransferase activity |
Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. |
TAS |
|
MF |
GO:0043426 |
MRF binding |
Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000197 |
Zinc finger, TAZ-type |
|
IPR000433 |
Zinc finger, ZZ-type |
|
IPR001487 |
Bromodomain |
|
IPR003101 |
Coactivator CBP, KIX domain |
|
IPR009110 |
Nuclear receptor coactivator, interlocking |
|
IPR010303 |
CREB-binding protein/p300, atypical RING domain |
|
IPR013178 |
Histone acetyltransferase Rtt109/CBP |
|
IPR014744 |
Nuclear receptor coactivator, CREB-bp-like, interlocking |
|
IPR018359 |
Bromodomain, conserved site |
|
IPR031162 |
CBP/p300-type histone acetyltransferase domain |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa04024 |
cAMP signaling pathway |
KEGG |
|
hsa04066 |
HIF-1 signaling pathway |
KEGG |
|
hsa04068 |
FoxO signaling pathway |
KEGG |
|
hsa04110 |
Cell cycle |
KEGG |
|
hsa04310 |
Wnt signaling pathway |
KEGG |
|
hsa04330 |
Notch signaling pathway |
KEGG |
|
hsa04350 |
TGF-beta signaling pathway |
KEGG |
|
hsa04520 |
Adherens junction |
KEGG |
|
hsa04630 |
Jak-STAT signaling pathway |
KEGG |
|
hsa04720 |
Long-term potentiation |
KEGG |
|
hsa04916 |
Melanogenesis |
KEGG |
|
hsa04919 |
Thyroid hormone signaling pathway |
KEGG |
|
hsa04922 |
Glucagon signaling pathway |
KEGG |
|
hsa05016 |
Huntington's disease |
KEGG |
|
hsa05152 |
Tuberculosis |
KEGG |
|
hsa05161 |
Hepatitis B |
KEGG |
|
hsa05164 |
Influenza A |
KEGG |
|
hsa05166 |
HTLV-I infection |
KEGG |
|
hsa05168 |
Herpes simplex infection |
KEGG |
|
hsa05169 |
Epstein-Barr virus infection |
KEGG |
|
hsa05200 |
Pathways in cancer |
KEGG |
|
hsa05203 |
Viral carcinogenesis |
KEGG |
|
hsa05206 |
MicroRNAs in cancer |
KEGG |
|
hsa05211 |
Renal cell carcinoma |
KEGG |
|
hsa05215 |
Prostate cancer |
KEGG |
|
WP560 |
TGF-beta Receptor Signaling |
WikiPathways |
|
WP706 |
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
WikiPathways |
|
WP399 |
Wnt Signaling Pathway and Pluripotency |
WikiPathways |
|
WP366 |
TGF-beta Signaling Pathway |
WikiPathways |
|
WP3414 |
Initiation of transcription and translation elongation at the HIV-1 LTR |
WikiPathways |
|
WP1539 |
Angiogenesis |
WikiPathways |
|
WP268 |
Notch Signaling Pathway |
WikiPathways |
|
WP3657 |
Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex |
WikiPathways |
|
WP364 |
IL-6 signaling pathway |
WikiPathways |
|
WP231 |
TNF alpha Signaling Pathway |
WikiPathways |
|
WP3651 |
Pathways Affected in Adenoid Cystic Carcinoma |
WikiPathways |
|
WP138 |
Androgen receptor signaling pathway |
WikiPathways |
|
h_RELAPathway |
Acetylation and Deacetylation of RelA in The Nucleus |
BioCarta |
|
h_CSKPathway |
Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor |
BioCarta |
|
h_carm-erPathway |
CARM1 and Regulation of the Estrogen Receptor |
BioCarta |
|
h_vdrPathway |
Control of Gene Expression by Vitamin D Receptor |
BioCarta |
|
h_setPathway |
Granzyme A mediated Apoptosis Pathway |
BioCarta |
|
h_il7Pathway |
IL-7 Signal Transduction |
BioCarta |
|
h_HuntingtonPathway |
Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors |
BioCarta |
|
h_pparaPathway |
Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) |
BioCarta |
|
h_pitx2Pathway |
Multi-step Regulation of Transcription by Pitx2 |
BioCarta |
|
h_nfatPathway |
NFAT and Hypertrophy of the heart (Transcription in the broken heart) |
BioCarta |
|
h_nthiPathway |
NFkB activation by Nontypeable Hemophilus influenzae |
BioCarta |
|
h_pelp1Pathway |
Pelp1 Modulation of Estrogen Receptor Activity |
BioCarta |
|
h_pmlPathway |
Regulation of transcriptional activity by PML |
BioCarta |
|
h_ppargPathway |
Role of PPAR-gamma Coactivators in Obesity and Thermogenesis |
BioCarta |
|
h_tgfbPathway |
TGF beta signaling pathway |
BioCarta |
|
h_pcafpathway |
The information-processing pathway at the IFN-beta enhancer |
BioCarta |
|
h_carm1Pathway |
Transcription Regulation by Methyltransferase of CARM1 |
BioCarta |
|
h_wntPathway |
WNT Signaling Pathway |
BioCarta |
| UMLS CUI | UMLS Term |
|---|---|
|
C0005695 |
Bladder Neoplasm |
|
C0007138 |
Carcinoma, Transitional Cell |
|
C0010606 |
Adenoid Cystic Carcinoma |
|
C0024301 |
Lymphoma, Follicular |
|
C0033578 |
Prostatic Neoplasms |
|
C0035934 |
Rubinstein-Taybi Syndrome |
|
C0036920 |
Sezary Syndrome |
|
C0149925 |
Small Cell Carcinoma Of Lung |
| Tissue | Cell Type |
|---|---|
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
placenta |
decidual cells |
|
rectum |
glandular cells |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22789864 |
Yan et al. |
2012 |
Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
NR4A1 |
3164 |
P22736 |
0.00 |
|
RBPJ |
3516 |
Q06330 |
0.00 |
|
KIT |
3815 |
P10721 |
0.00 |
|
MAX |
4149 |
P61244 |
0.00 |
|
MITF |
4286 |
O75030 |
0.00 |
|
PPARD |
5467 |
Q03181 |
0.00 |
|
PRKX |
5613 |
P51817 |
0.00 |
|
TCF7L2 |
6934 |
Q9NQB0 |
0.00 |
|
TCF7L1 |
83439 |
Q9HCS4 |
0.00 |
|
RORC |
6097 |
P51449 |
0.49 |
|
TLE3 |
7090 |
Q04726 |
0.49 |
|
BCL6 |
604 |
P41182 |
0.52 |
|
CCNC |
892 |
P24863 |
0.52 |
|
CDC25B |
994 |
P30305 |
0.52 |
|
DACH1 |
1602 |
Q9UI36 |
0.52 |
|
GABPA |
2551 |
Q06546 |
0.52 |
|
HIST1H2BB |
3018 |
P33778 |
0.52 |
|
H3F3A; H3F3B |
3020 |
P84243 |
0.52 |
|
HMGB1 |
3146 |
P09429 |
0.52 |
|
HMGB2 |
3148 |
P26583 |
0.52 |
|
LDLR |
3949 |
P01130 |
0.52 |
|
NFIA |
4774 |
Q12857 |
0.52 |
|
NFIC |
4782 |
P08651 |
0.52 |
|
STAT4 |
6775 |
Q14765 |
0.52 |
|
SUV39H1 |
6839 |
O43463 |
0.52 |
|
YWHAH |
7533 |
Q04917 |
0.52 |
|
DEK |
7913 |
P35659 |
0.52 |
|
HIST2H2BE |
8349 |
Q16778 |
0.52 |
|
SERTAD2 |
9792 |
Q14140 |
0.52 |
|
PSME3 |
10197 |
P61289 |
0.52 |
|
KLF2 |
10365 |
Q9Y5W3 |
0.52 |
|
GMEB1 |
10691 |
Q9Y692 |
0.52 |
|
KPNA6 |
23633 |
O60684 |
0.52 |
|
GMEB2 |
26205 |
Q9UKD1 |
0.52 |
|
SERTAD3 |
29946 |
Q9UJW9 |
0.52 |
|
CRX |
1406 |
O43186 |
0.55 |
|
E2F5 |
1875 |
Q15329 |
0.55 |
|
ELF3 |
1999 |
P78545 |
0.55 |
|
MAFG |
4097 |
O15525 |
0.55 |
|
SOX9 |
6662 |
P48436 |
0.55 |
|
SPIB |
6689 |
Q01892 |
0.55 |
|
HNF1B |
6928 |
P35680 |
0.55 |
|
UBTF |
7343 |
P17480 |
0.55 |
|
GATA2 |
2624 |
P23769 |
0.56 |
|
HOXD12 |
3238 |
P35452 |
0.56 |
|
HOXD13 |
3239 |
P35453 |
0.56 |
|
IRF1 |
3659 |
P10914 |
0.56 |
|
PBX1 |
5087 |
P40424 |
0.56 |
|
UBE2D1 |
7321 |
P51668 |
0.56 |
|
TAF6L |
10629 |
Q9Y6J9 |
0.56 |
|
IRF7 |
3665 |
Q92985 |
0.59 |
|
BCL3 |
602 |
P20749 |
0.62 |
|
HOXB4 |
3214 |
P17483 |
0.62 |
|
APC |
324 |
P25054 |
0.63 |
|
CCNE1 |
898 |
P24864 |
0.63 |
|
CNN1 |
1264 |
P51911 |
0.63 |
|
FOSB |
2354 |
P53539 |
0.63 |
|
JUNB |
3726 |
P17275 |
0.63 |
|
MAP3K5 |
4217 |
Q99683 |
0.63 |
|
MYH9 |
4627 |
P35579 |
0.63 |
|
NFYB |
4801 |
P25208 |
0.63 |
|
PCYT1A |
5130 |
P49585 |
0.63 |
|
MAPK10 |
5602 |
P53779 |
0.63 |
|
PSMC5 |
5705 |
P62195 |
0.63 |
|
SMARCC1 |
6599 |
Q92922 |
0.63 |
|
SMARCC2 |
6601 |
Q8TAQ2 |
0.63 |
|
SP3 |
6670 |
Q02447 |
0.63 |
|
TRIM21 |
6737 |
P19474 |
0.63 |
|
STAT5A |
6776 |
P42229 |
0.63 |
|
STAT5B |
6777 |
P51692 |
0.63 |
|
ZEB1 |
6935 |
P37275 |
0.63 |
|
TLR2 |
7097 |
O60603 |
0.63 |
|
SUMO1 |
7341 |
P63165 |
0.63 |
|
MAFK |
7975 |
O60675 |
0.63 |
|
FOSL1 |
8061 |
P15407 |
0.63 |
|
PIAS1 |
8554 |
O75925 |
0.63 |
|
NMI |
9111 |
Q13287 |
0.63 |
|
MAFB |
9935 |
Q9Y5Q3 |
0.63 |
|
IRF9 |
10379 |
Q00978 |
0.63 |
|
PAPOLA |
10914 |
P51003 |
0.63 |
|
CPSF6 |
11052 |
Q16630 |
0.63 |
|
WDR5 |
11091 |
P61964 |
0.63 |
|
KLF8 |
11279 |
O95600 |
0.63 |
|
CRTC1 |
23373 |
Q6UUV9 |
0.63 |
|
BRMS1 |
25855 |
Q9HCU9 |
0.63 |
|
PTOV1 |
53635 |
Q86YD1 |
0.63 |
|
HES6 |
55502 |
Q96HZ4 |
0.63 |
|
ATG3 |
64422 |
Q9NT62 |
0.63 |
|
ZCCHC12 |
170261 |
Q6PEW1 |
0.63 |
|
Q6ZTM8_HUMAN |
N/A |
Q6ZTM8 |
0.63 |
|
PARP1 |
142 |
P09874 |
0.65 |
|
HIST3H3 |
8290 |
Q16695 |
0.65 |
|
TACC2 |
10579 |
O95359 |
0.65 |
|
ZNF639 |
51193 |
Q9UID6 |
0.65 |
|
ZBTB2 |
57621 |
Q8N680 |
0.65 |
|
MAML2 |
84441 |
Q8IZL2 |
0.65 |
|
FHL2 |
2274 |
Q14192 |
0.67 |
|
FOXM1 |
2305 |
Q08050 |
0.67 |
|
MSH6 |
2956 |
P52701 |
0.67 |
|
NPAT |
4863 |
Q14207 |
0.67 |
|
RXRG |
6258 |
P48443 |
0.67 |
|
SND1 |
27044 |
Q7KZF4 |
0.67 |
|
CDK5RAP3 |
80279 |
Q96JB5 |
0.67 |
|
DDX17 |
10521 |
Q92841 |
0.68 |
|
ANAPC5 |
51433 |
Q9UJX4 |
0.68 |
|
XAF1 |
54739 |
Q6GPH4 |
0.68 |
|
PCNA |
5111 |
P12004 |
0.70 |
|
HIST1H3A |
8350 |
P68431 |
0.70 |
|
HDAC3 |
8841 |
O15379 |
0.70 |
|
POU2F3 |
25833 |
Q9UKI9 |
0.70 |
|
CENPJ |
55835 |
Q9HC77 |
0.71 |
|
EID3 |
493861 |
Q8N140 |
0.71 |
|
AP1B1 |
162 |
Q10567 |
0.72 |
|
EIF2B1 |
1967 |
Q14232 |
0.72 |
|
GAK |
2580 |
O14976 |
0.72 |
|
CNOT3 |
4849 |
O75175 |
0.72 |
|
RPS6KA2 |
6196 |
Q15349 |
0.72 |
|
ZBTB17 |
7709 |
Q13105 |
0.72 |
|
RUVBL1 |
8607 |
Q9Y265 |
0.72 |
|
TRIP10 |
9322 |
Q15642 |
0.72 |
|
PIAS3 |
10401 |
Q9Y6X2 |
0.72 |
|
CDC27 |
996 |
P30260 |
0.73 |
|
CDK8 |
1024 |
P49336 |
0.73 |
|
CSK |
1445 |
P41240 |
0.73 |
|
HDAC2 |
3066 |
Q92769 |
0.73 |
|
MGMT |
4255 |
P16455 |
0.73 |
|
RARA |
5914 |
P10276 |
0.73 |
|
VDR |
7421 |
P11473 |
0.73 |
|
PELP1 |
27043 |
Q8IZL8 |
0.73 |
|
DDX5 |
1655 |
P17844 |
0.74 |
|
CITED1 |
4435 |
Q99966 |
0.74 |
|
RPS6KA3 |
6197 |
P51812 |
0.74 |
|
SNAI1 |
6615 |
O95863 |
0.74 |
|
SP1 |
6667 |
P08047 |
0.74 |
|
HDAC1 |
3065 |
Q13547 |
0.75 |
|
RBBP7 |
5931 |
Q16576 |
0.75 |
|
ATF1 |
466 |
P18846 |
0.76 |
|
HOXA9 |
3205 |
P31269 |
0.76 |
|
RPA2 |
6118 |
P15927 |
0.76 |
|
HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A; HIST2H4B; HIST4H4 |
121504 |
P62805 |
0.76 |
|
SMAD4 |
4089 |
Q13485 |
0.77 |
|
KLF13 |
51621 |
Q9Y2Y9 |
0.77 |
|
CNTN2 |
6900 |
Q02246 |
0.78 |
|
CUX1 |
1523 |
Q13948 |
0.79 |
|
EBF1 |
1879 |
Q9UH73 |
0.79 |
|
EGR1 |
1958 |
P18146 |
0.79 |
|
KPNA2 |
3838 |
P52292 |
0.79 |
|
SRC |
6714 |
P12931 |
0.79 |
|
CREBBP |
1387 |
Q92793 |
0.80 |
|
CTBP1 |
1487 |
Q13363 |
0.80 |
|
MAF |
4094 |
O75444 |
0.80 |
|
NKX2-1 |
7080 |
P43699 |
0.80 |
|
KLF1 |
10661 |
Q13351 |
0.80 |
|
MYBL1 |
4603 |
P10243 |
0.81 |
|
MDC1 |
9656 |
Q14676 |
0.81 |
|
GATA1 |
2623 |
P15976 |
0.82 |
|
SMAD1 |
4086 |
Q15797 |
0.82 |
|
GCM1 |
8521 |
Q9NP62 |
0.82 |
|
MTDH |
92140 |
Q86UE4 |
0.82 |
|
SMARCB1 |
6598 |
Q12824 |
0.83 |
|
IKBKB |
3551 |
O14920 |
0.84 |
|
MSX1 |
4487 |
P28360 |
0.84 |
|
XRCC6 |
2547 |
P12956 |
0.85 |
|
DAXX |
1616 |
Q9UER7 |
0.86 |
|
STAT3 |
6774 |
P40763 |
0.86 |
|
NCOA2 |
10499 |
Q15596 |
0.86 |
|
MECOM |
2122 |
Q03112 |
0.87 |
|
EWSR1 |
2130 |
Q01844 |
0.87 |
|
FOS |
2353 |
P01100 |
0.87 |
|
HTT |
3064 |
P42858 |
0.87 |
|
SMAD2 |
4087 |
Q15796 |
0.87 |
|
SRF |
6722 |
P11831 |
0.87 |
|
CSNK2A1 |
1457 |
P68400 |
0.88 |
|
CSNK2A2 |
1459 |
P19784 |
0.88 |
|
GLI3 |
2737 |
P10071 |
0.88 |
|
HOXB7 |
3217 |
P09629 |
0.88 |
|
PTMA |
5757 |
P06454 |
0.88 |
|
HNF1A |
6927 |
P20823 |
0.88 |
|
BRCA1 |
672 |
P38398 |
0.89 |
|
NR3C1 |
2908 |
P04150 |
0.89 |
|
GTF2B |
2959 |
Q00403 |
0.89 |
|
KMT2A |
4297 |
Q03164 |
0.89 |
|
FOXO4 |
4303 |
P98177 |
0.89 |
|
SH3GL1 |
6455 |
Q99961 |
0.89 |
|
SERTAD1 |
29950 |
Q9UHV2 |
0.89 |
|
AR |
367 |
P10275 |
0.90 |
|
ATF2 |
1386 |
P15336 |
0.90 |
|
ESR1 |
2099 |
P03372 |
0.90 |
|
FOXO1 |
2308 |
Q12778 |
0.90 |
|
JUN |
3725 |
P05412 |
0.90 |
|
MYB |
4602 |
P10242 |
0.90 |
|
MYOD1 |
4654 |
P15172 |
0.90 |
|
PML |
5371 |
P29590 |
0.90 |
|
TP53 |
7157 |
P04637 |
0.90 |
|
CHUK |
1147 |
O15111 |
0.92 |
|
SMAD3 |
4088 |
P84022 |
0.94 |
|
CTNNB1 |
1499 |
P35222 |
0.96 |
|
RELA |
5970 |
Q04206 |
0.97 |
|
CREB1 |
1385 |
P16220 |
0.99 |
|
CDKN2B |
1030 |
P42772 |
0.00 |
|
CCNE2 |
9134 |
O96020 |
0.00 |
|
CREB3 |
10488 |
O43889 |
0.00 |
|
UBE2S |
27338 |
Q16763 |
0.49 |
|
ACVR1 |
90 |
Q04771 |
0.52 |
|
CEBPA |
1050 |
P49715 |
0.52 |
|
HLF |
3131 |
Q16534 |
0.52 |
|
NFKB2 |
4791 |
Q00653 |
0.52 |
|
MAPK1 |
5594 |
P28482 |
0.52 |
|
MAPK3 |
5595 |
P27361 |
0.52 |
|
PROX1 |
5629 |
Q92786 |
0.52 |
|
MBD2 |
8932 |
Q9UBB5 |
0.52 |
|
CALCOCO1 |
57658 |
Q9P1Z2 |
0.52 |
|
JDP2 |
122953 |
Q8WYK2 |
0.52 |
|
CAMK4 |
814 |
Q16566 |
0.55 |
|
HOXA11 |
3207 |
P31270 |
0.55 |
|
HOXB1 |
3211 |
P14653 |
0.55 |
|
PCMT1 |
5110 |
P22061 |
0.55 |
|
PRKCD |
5580 |
Q05655 |
0.55 |
|
THRA |
7067 |
P10827 |
0.55 |
|
NR5A1 |
2516 |
Q13285 |
0.56 |
|
HCK |
3055 |
P08631 |
0.56 |
|
LYN |
4067 |
P07948 |
0.56 |
|
PLAGL1 |
5325 |
Q9UM63 |
0.56 |
|
MIER1 |
57708 |
Q8N108 |
0.56 |
|
CEBPB |
1051 |
P17676 |
0.59 |
|
CEBPD |
1052 |
P49716 |
0.59 |
|
KAT2A |
2648 |
Q92830 |
0.59 |
|
CREM |
1390 |
Q03060 |
0.62 |
|
HOXA10 |
3206 |
P31260 |
0.62 |
|
HOXB2 |
3212 |
P14652 |
0.62 |
|
HOXB3 |
3213 |
P14651 |
0.62 |
|
HOXB9 |
3219 |
P17482 |
0.62 |
|
HOXD4 |
3233 |
P09016 |
0.62 |
|
HOXD10 |
3236 |
P28358 |
0.62 |
|
HSF1 |
3297 |
Q00613 |
0.62 |
|
TCF12 |
6938 |
Q99081 |
0.62 |
|
BMI1 |
648 |
P35226 |
0.63 |
|
RUNX2 |
860 |
Q13950 |
0.63 |
|
CCNA2 |
890 |
P20248 |
0.63 |
|
CCND3 |
896 |
P30281 |
0.63 |
|
CDH1 |
999 |
P12830 |
0.63 |
|
DDIT3 |
1649 |
P35638 |
0.63 |
|
E2F3 |
1871 |
O00716 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
EPAS1 |
2034 |
Q99814 |
0.63 |
|
ESR2 |
2100 |
Q92731 |
0.63 |
|
FHL1 |
2273 |
Q13642 |
0.63 |
|
LIG4 |
3981 |
P49917 |
0.63 |
|
NR3C2 |
4306 |
P08235 |
0.63 |
|
MTF1 |
4520 |
Q14872 |
0.63 |
|
PTMS |
5763 |
P20962 |
0.63 |
|
RAC3 |
5881 |
P60763 |
0.63 |
|
SMARCA2 |
6595 |
P51531 |
0.63 |
|
TBP |
6908 |
P20226 |
0.63 |
|
TFAP2B |
7021 |
Q92481 |
0.63 |
|
YY1 |
7528 |
P25490 |
0.63 |
|
MKNK1 |
8569 |
Q9BUB5 |
0.63 |
|
CDC16 |
8881 |
Q13042 |
0.63 |
|
PHOX2B |
8929 |
Q99453 |
0.63 |
|
MED23 |
9439 |
Q9ULK4 |
0.63 |
|
NCOR1 |
9611 |
O75376 |
0.63 |
|
NCOR2 |
9612 |
Q9Y618 |
0.63 |
|
TRIM28 |
10155 |
Q13263 |
0.63 |
|
PPP1R13L |
10848 |
Q8WUF5 |
0.63 |
|
GRIP1 |
23426 |
Q9Y3R0 |
0.63 |
|
POT1 |
25913 |
Q9NUX5 |
0.63 |
|
ANAPC2 |
29882 |
Q9UJX6 |
0.63 |
|
TBX21 |
30009 |
Q9UL17 |
0.63 |
|
TXNDC11 |
51061 |
Q6PKC3 |
0.63 |
|
KDM3B |
51780 |
Q7LBC6 |
0.63 |
|
CRTC2 |
200186 |
Q53ET0 |
0.63 |
|
C3orf62 |
375341 |
Q6ZUJ4 |
0.63 |
|
ACTA2 |
59 |
P62736 |
0.65 |
|
CDH2 |
1000 |
P19022 |
0.65 |
|
WT1 |
7490 |
P19544 |
0.65 |
|
RPS6KA5 |
9252 |
O75582 |
0.65 |
|
KAT5 |
10524 |
Q92993 |
0.65 |
|
HBP1 |
26959 |
O60381 |
0.65 |
|
ELK1 |
2002 |
P19419 |
0.67 |
|
MSH2 |
4436 |
P43246 |
0.67 |
|
PAX5 |
5079 |
Q02548 |
0.67 |
|
ALX1 |
8092 |
Q15699 |
0.67 |
|
ATF3 |
467 |
P18847 |
0.68 |
|
RAD23A |
5886 |
P54725 |
0.68 |
|
REL |
5966 |
Q04864 |
0.68 |
|
SETD1A |
9739 |
O15047 |
0.68 |
|
SS18L1 |
26039 |
O75177 |
0.68 |
|
PYGO2 |
90780 |
Q9BRQ0 |
0.68 |
|
TP73 |
7161 |
O15350 |
0.69 |
|
AKT1 |
207 |
P31749 |
0.70 |
|
POU1F1 |
5449 |
P28069 |
0.70 |
|
PRLR |
5618 |
P16471 |
0.70 |
|
ABCA1 |
19 |
O95477 |
0.72 |
|
DYRK1A |
1859 |
Q13627 |
0.72 |
|
ING1 |
3621 |
Q9UK53 |
0.72 |
|
MEIS1 |
4211 |
O00470 |
0.72 |
|
SPI1 |
6688 |
P17947 |
0.72 |
|
WRN |
7486 |
Q14191 |
0.72 |
|
DYRK1B |
9149 |
Q9Y463 |
0.72 |
|
COPS2 |
9318 |
P61201 |
0.72 |
|
MED21 |
9412 |
Q13503 |
0.72 |
|
CDC20 |
991 |
Q12834 |
0.73 |
|
MAML1 |
9794 |
Q92585 |
0.73 |
|
CITED2 |
10370 |
Q99967 |
0.73 |
|
N4BP2 |
55728 |
Q86UW6 |
0.73 |
|
MED25 |
81857 |
Q71SY5 |
0.73 |
|
SNIP1 |
79753 |
Q8TAD8 |
0.74 |
|
PHOX2A |
401 |
O14813 |
0.75 |
|
CDKN1A |
1026 |
P38936 |
0.75 |
|
NAP1L1 |
4673 |
P55209 |
0.75 |
|
NPAS2 |
4862 |
Q99743 |
0.75 |
|
POLR2A |
5430 |
P24928 |
0.75 |
|
SMARCA4 |
6597 |
P51532 |
0.75 |
|
UBE2I |
7329 |
P63279 |
0.75 |
|
HMGA1 |
3159 |
P17096 |
0.76 |
|
IFNAR2 |
3455 |
P48551 |
0.76 |
|
NLK |
51701 |
Q9UBE8 |
0.77 |
|
MDM2 |
4193 |
Q00987 |
0.78 |
|
ATXN3 |
4287 |
P54252 |
0.78 |
|
RPS6KA1 |
6195 |
Q15418 |
0.78 |
|
TFDP1 |
7027 |
Q14186 |
0.78 |
|
KAT6A |
7994 |
Q92794 |
0.78 |
|
TRIP4 |
9325 |
Q15650 |
0.78 |
|
PPARGC1A |
10891 |
Q9UBK2 |
0.78 |
|
EID1 |
23741 |
Q9Y6B2 |
0.78 |
|
ANAPC7 |
51434 |
Q9UJX3 |
0.78 |
|
FGFR1 |
2260 |
P11362 |
0.79 |
|
NEUROG1 |
4762 |
Q92886 |
0.79 |
|
NFATC4 |
4776 |
Q14934 |
0.79 |
|
NFE2 |
4778 |
Q16621 |
0.79 |
|
TRERF1 |
55809 |
Q96PN7 |
0.79 |
|
TGS1 |
96764 |
Q96RS0 |
0.79 |
|
E2F1 |
1869 |
Q01094 |
0.81 |
|
HOXB6 |
3216 |
P17509 |
0.81 |
|
RUNX1 |
861 |
Q01196 |
0.82 |
|
ETS1 |
2113 |
P14921 |
0.82 |
|
ETS2 |
2114 |
P15036 |
0.82 |
|
AIRE |
326 |
O43918 |
0.83 |
|
CDK2 |
1017 |
P24941 |
0.83 |
|
IKBKG |
8517 |
Q9Y6K9 |
0.83 |
|
SRCAP |
10847 |
Q6ZRS2 |
0.83 |
|
HIPK2 |
28996 |
Q9H2X6 |
0.83 |
|
MYBL2 |
4605 |
P10244 |
0.84 |
|
NFATC2 |
4773 |
Q13469 |
0.85 |
|
MYC |
4609 |
P01106 |
0.86 |
|
CARM1 |
10498 |
Q86X55 |
0.87 |
|
ATF4 |
468 |
P18848 |
0.88 |
|
KLF5 |
688 |
Q13887 |
0.88 |
|
CDX2 |
1045 |
Q99626 |
0.88 |
|
EP300 |
2033 |
Q09472 |
0.88 |
|
ONECUT1 |
3175 |
Q9UBC0 |
0.88 |
|
IRF5 |
3663 |
Q13568 |
0.88 |
|
NUP98 |
4928 |
P52948 |
0.88 |
|
PPARG |
5468 |
P37231 |
0.88 |
|
FOXO3 |
2309 |
O43524 |
0.89 |
|
RBBP4 |
5928 |
Q09028 |
0.89 |
|
SREBF1 |
6720 |
P36956 |
0.89 |
|
SREBF2 |
6721 |
Q12772 |
0.89 |
|
STAT1 |
6772 |
P42224 |
0.89 |
|
STAT2 |
6773 |
P52630 |
0.89 |
|
STAT6 |
6778 |
P42226 |
0.89 |
|
HNF4A |
3172 |
P41235 |
0.90 |
|
IRF3 |
3661 |
Q14653 |
0.90 |
|
NFE2L2 |
4780 |
Q16236 |
0.90 |
|
TCF3 |
6929 |
P15923 |
0.90 |
|
TDG |
6996 |
Q13569 |
0.90 |
|
NCOA1 |
8648 |
Q15788 |
0.90 |
|
KAT2B |
8850 |
Q92831 |
0.90 |
|
KLF4 |
9314 |
O43474 |
0.90 |
|
NCOA6 |
23054 |
Q14686 |
0.90 |
|
NCOA3 |
8202 |
Q9Y6Q9 |
0.95 |
|
KHDRBS1 |
10657 |
Q07666 |
0.96 |
|
HIF1A |
3091 |
Q16665 |
0.97 |