BP

GO:0001666

response to hypoxia

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

IDA

BP

GO:0001764

neuron migration

The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.

ISS

BP

GO:0007420

brain development

The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

ISS

BP

GO:0008283

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

ISS

BP

GO:0010801

negative regulation of peptidyl-threonine phosphorylation

Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.

ISS

BP

GO:0030182

neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron.

ISS

BP

GO:0032007

negative regulation of TOR signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.

IMP

BP

GO:0033137

negative regulation of peptidyl-serine phosphorylation

Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.

ISS

BP

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

ISS

BP

GO:0043241

protein complex disassembly

The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.

IEA

BP

GO:0045820

negative regulation of glycolytic process

Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.

IEA

BP

GO:0048011

neurotrophin TRK receptor signaling pathway

A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.

ISS

BP

GO:0051607

defense response to virus

Reactions triggered in response to the presence of a virus that act to protect the cell or organism.

IEA

BP

GO:0072593

reactive oxygen species metabolic process

The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.

IEA

BP

GO:1901216

positive regulation of neuron death

Any process that activates or increases the frequency, rate or extent of neuron death.

ISS

BP

GO:1902532

negative regulation of intracellular signal transduction

Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.

ISS

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005739

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0071889

14-3-3 protein binding

Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.

IEA