| Gene Symbol | CPSF2 |
| Entrez ID | 53981 |
| Uniprot ID | Q9P2I0 |
| Description | cleavage and polyadenylation specific factor 2 |
| Chromosomal Location | chr14: 92,121,937-92,172,145 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
TAS |
|
BP |
GO:0006369 |
termination of RNA polymerase II transcription |
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. |
TAS |
|
BP |
GO:0006378 |
mRNA polyadenylation |
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. |
IEA |
|
BP |
GO:0006379 |
mRNA cleavage |
Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. |
IEA |
|
BP |
GO:0006398 |
mRNA 3'-end processing by stem-loop binding and cleavage |
Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine. |
IDA |
|
BP |
GO:0006406 |
mRNA export from nucleus |
The directed movement of mRNA from the nucleus to the cytoplasm. |
TAS |
|
BP |
GO:0031124 |
mRNA 3'-end processing |
Any process involved in forming the mature 3' end of an mRNA molecule. |
TAS |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0005847 |
mRNA cleavage and polyadenylation specificity factor complex |
A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. |
IDA |
|
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
|
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
| Domain ID | Description |
|---|---|
|
IPR001279 |
Metallo-beta-lactamase |
|
IPR011108 |
Zn-dependent metallo-hydrolase, RNA specificity domain |
|
IPR022712 |
Beta-Casp domain |
|
IPR025069 |
Cleavage and polyadenylation specificity factor 2, C-terminal |
|
IPR027075 |
Cleavage and polyadenylation specificity factor subunit 2 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03015 |
mRNA surveillance pathway |
KEGG |
|
WP411 |
mRNA Processing |
WikiPathways |
|
h_cpsfPathway |
Polyadenylation of mRNA |
BioCarta |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
adipocytes |
|
soft tissue |
fibroblasts |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22789864 |
Yan et al. |
2012 |
Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
SMARCA4 |
6597 |
P51532 |
0.49 |
|
SMARCD3 |
6604 |
Q6STE5 |
0.49 |
|
SUPT5H |
6829 |
O00267 |
0.49 |
|
GTF3C3 |
9330 |
Q9Y5Q9 |
0.49 |
|
MED17 |
9440 |
Q9NVC6 |
0.49 |
|
RALBP1 |
10928 |
Q15311 |
0.49 |
|
POLE3 |
54107 |
Q9NRF9 |
0.49 |
|
ISY1 |
57461 |
Q9ULR0 |
0.49 |
|
GTF3C6 |
112495 |
Q969F1 |
0.49 |
|
PAPOLA |
10914 |
P51003 |
0.56 |
|
CSTF2T |
23283 |
Q9H0L4 |
0.63 |
|
WDR33 |
55339 |
Q9C0J8 |
0.65 |
|
SYMPK |
8189 |
Q92797 |
0.83 |
|
FIP1L1 |
81608 |
Q6UN15 |
0.83 |
|
PSMB3 |
5691 |
P49720 |
0.49 |
|
PSMB4 |
5692 |
P28070 |
0.49 |
|
PSMB5 |
5693 |
P28074 |
0.49 |
|
PSMB6 |
5694 |
P28072 |
0.49 |
|
CPSF4 |
10898 |
O95639 |
0.49 |
|
PCF11 |
51585 |
O94913 |
0.56 |
|
TUT1 |
64852 |
Q9H6E5 |
0.56 |
|
POLR2A |
5430 |
P24928 |
0.59 |
|
BARD1 |
580 |
Q99728 |
0.63 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
ECT2 |
1894 |
Q9H8V3 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
EZH2 |
2146 |
Q15910 |
0.63 |
|
HNRNPA1 |
3178 |
P09651 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MYC |
4609 |
P01106 |
0.63 |
|
NPM1 |
4869 |
P06748 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PCBP2 |
5094 |
Q15366 |
0.63 |
|
PSMA3 |
5684 |
P25788 |
0.63 |
|
RBBP6 |
5930 |
Q7Z6E9 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
TBP |
6908 |
P20226 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
MDC1 |
9656 |
Q14676 |
0.63 |
|
RRAGA |
10670 |
Q7L523 |
0.63 |
|
SNW1 |
22938 |
Q13573 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
DDX41 |
51428 |
Q9UJV9 |
0.63 |
|
SMARCAD1 |
56916 |
Q9H4L7 |
0.63 |
|
HECW2 |
57520 |
Q9P2P5 |
0.63 |
|
CDC73 |
79577 |
Q6P1J9 |
0.63 |
|
CPSF1 |
29894 |
Q10570 |
0.65 |
|
CLP1 |
10978 |
Q92989 |
0.70 |
|
CLK2 |
1196 |
P49760 |
0.72 |
|
FOXL1 |
2300 |
Q12952 |
0.72 |
|
CEP170P1 |
645455 |
Q96L14 |
0.72 |
|
WWOX |
51741 |
Q9NZC7 |
0.78 |
|
RNPS1 |
10921 |
Q15287 |
0.88 |
|
CPSF3 |
51692 |
Q9UKF6 |
0.89 |
|
CSTF2 |
1478 |
P33240 |
0.94 |