| Gene Symbol | CPSF2 |
| Entrez ID | 53981 |
| Uniprot ID | Q9P2I0 |
| Description | cleavage and polyadenylation specific factor 2 |
| Chromosomal Location | chr14: 92,121,937-92,172,145 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0000398 | mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | TAS |
BP | GO:0006369 | termination of RNA polymerase II transcription |
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed. | TAS |
BP | GO:0006378 | mRNA polyadenylation |
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. | IEA |
BP | GO:0006379 | mRNA cleavage |
Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. | IEA |
BP | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage |
Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine. | IDA |
BP | GO:0006406 | mRNA export from nucleus |
The directed movement of mRNA from the nucleus to the cytoplasm. | TAS |
BP | GO:0031124 | mRNA 3'-end processing |
Any process involved in forming the mature 3' end of an mRNA molecule. | TAS |
CC | GO:0005654 | nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. | TAS |
CC | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. | IDA |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IDA |
MF | GO:0003723 | RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | IEA |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
| Domain ID | Description |
|---|---|
IPR001279 | Metallo-beta-lactamase |
IPR011108 | Zn-dependent metallo-hydrolase, RNA specificity domain |
IPR022712 | Beta-Casp domain |
IPR025069 | Cleavage and polyadenylation specificity factor 2, C-terminal |
IPR027075 | Cleavage and polyadenylation specificity factor subunit 2 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa03015 | mRNA surveillance pathway | KEGG |
WP411 | mRNA Processing | WikiPathways |
h_cpsfPathway | Polyadenylation of mRNA | BioCarta |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
appendix | lymphoid tissue |
bone marrow | hematopoietic cells |
bronchus | respiratory epithelial cells |
caudate | glial cells |
caudate | neuronal cells |
cerebellum | cells in molecular layer |
cerebellum | Purkinje cells |
cerebral cortex | endothelial cells |
cerebral cortex | glial cells |
cerebral cortex | neuronal cells |
cervix, uterine | glandular cells |
cervix, uterine | squamous epithelial cells |
colon | endothelial cells |
colon | glandular cells |
duodenum | glandular cells |
endometrium | glandular cells |
epididymis | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
heart muscle | myocytes |
hippocampus | neuronal cells |
kidney | cells in glomeruli |
kidney | cells in tubules |
lung | pneumocytes |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
pancreas | exocrine glandular cells |
pancreas | islets of Langerhans |
parathyroid gland | glandular cells |
placenta | decidual cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
seminal vesicle | glandular cells |
skin | fibroblasts |
skin | keratinocytes |
skin | Langerhans |
skin | melanocytes |
skin | epidermal cells |
small intestine | glandular cells |
soft tissue | adipocytes |
soft tissue | fibroblasts |
stomach | glandular cells |
testis | cells in seminiferous ducts |
testis | Leydig cells |
thyroid gland | glandular cells |
urinary bladder | urothelial cells |
vagina | squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22789864 | Yan et al. | 2012 | Expression of apoptosis-related genes in the endometrium of polycystic ovary syndrome patients during the window of implantation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
SMARCA4 | 6597 | P51532 | 0.49 |
SMARCD3 | 6604 | Q6STE5 | 0.49 |
SUPT5H | 6829 | O00267 | 0.49 |
GTF3C3 | 9330 | Q9Y5Q9 | 0.49 |
MED17 | 9440 | Q9NVC6 | 0.49 |
RALBP1 | 10928 | Q15311 | 0.49 |
POLE3 | 54107 | Q9NRF9 | 0.49 |
ISY1 | 57461 | Q9ULR0 | 0.49 |
GTF3C6 | 112495 | Q969F1 | 0.49 |
PAPOLA | 10914 | P51003 | 0.56 |
CSTF2T | 23283 | Q9H0L4 | 0.63 |
WDR33 | 55339 | Q9C0J8 | 0.65 |
SYMPK | 8189 | Q92797 | 0.83 |
FIP1L1 | 81608 | Q6UN15 | 0.83 |
PSMB3 | 5691 | P49720 | 0.49 |
PSMB4 | 5692 | P28070 | 0.49 |
PSMB5 | 5693 | P28074 | 0.49 |
PSMB6 | 5694 | P28072 | 0.49 |
CPSF4 | 10898 | O95639 | 0.49 |
PCF11 | 51585 | O94913 | 0.56 |
TUT1 | 64852 | Q9H6E5 | 0.56 |
POLR2A | 5430 | P24928 | 0.59 |
BARD1 | 580 | Q99728 | 0.63 |
CDC5L | 988 | Q99459 | 0.63 |
ECT2 | 1894 | Q9H8V3 | 0.63 |
ELAVL1 | 1994 | Q15717 | 0.63 |
EZH2 | 2146 | Q15910 | 0.63 |
HNRNPA1 | 3178 | P09651 | 0.63 |
JUN | 3725 | P05412 | 0.63 |
MYC | 4609 | P01106 | 0.63 |
NPM1 | 4869 | P06748 | 0.63 |
NTRK1 | 4914 | P04629 | 0.63 |
PCBP2 | 5094 | Q15366 | 0.63 |
PSMA3 | 5684 | P25788 | 0.63 |
RBBP6 | 5930 | Q7Z6E9 | 0.63 |
SUMO2 | 6613 | P61956 | 0.63 |
TBP | 6908 | P20226 | 0.63 |
CUL3 | 8452 | Q13618 | 0.63 |
MDC1 | 9656 | Q14676 | 0.63 |
RRAGA | 10670 | Q7L523 | 0.63 |
SNW1 | 22938 | Q13573 | 0.63 |
OBSL1 | 23363 | O75147 | 0.63 |
DDX41 | 51428 | Q9UJV9 | 0.63 |
SMARCAD1 | 56916 | Q9H4L7 | 0.63 |
HECW2 | 57520 | Q9P2P5 | 0.63 |
CDC73 | 79577 | Q6P1J9 | 0.63 |
CPSF1 | 29894 | Q10570 | 0.65 |
CLP1 | 10978 | Q92989 | 0.7 |
CLK2 | 1196 | P49760 | 0.72 |
FOXL1 | 2300 | Q12952 | 0.72 |
CEP170P1 | 645455 | Q96L14 | 0.72 |
WWOX | 51741 | Q9NZC7 | 0.78 |
RNPS1 | 10921 | Q15287 | 0.88 |
CPSF3 | 51692 | Q9UKF6 | 0.89 |
CSTF2 | 1478 | P33240 | 0.94 |