BP

GO:0006165

nucleoside diphosphate phosphorylation

The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate.

IDA

BP

GO:0006207

de novo' pyrimidine nucleobase biosynthetic process

The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.

IEA

BP

GO:0006222

UMP biosynthetic process

The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate.

IEA

BP

GO:0009142

nucleoside triphosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.

IDA

BP

GO:0009220

pyrimidine ribonucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

TAS

BP

GO:0015949

nucleobase-containing small molecule interconversion

The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule.

TAS

BP

GO:0046940

nucleoside monophosphate phosphorylation

The process of introducing one or more phosphate groups into a nucleoside monophosphate to produce a polyphosphorylated nucleoside.

IEA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

TAS

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0004127

cytidylate kinase activity

Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.

IEA

MF

GO:0004550

nucleoside diphosphate kinase activity

Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

IDA

MF

GO:0004849

uridine kinase activity

Catalysis of the reaction: ATP + uridine = ADP + UMP.

TAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0009041

uridylate kinase activity

Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.

IEA

MF

GO:0050145

nucleoside phosphate kinase activity

Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate.

EXP