| Gene Symbol | COX7C |
| Entrez ID | 1350 |
| Uniprot ID | P15954 |
| Description | cytochrome c oxidase subunit VIIc |
| Chromosomal Location | chr5: 86,617,904-86,620,962 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006091 | generation of precursor metabolites and energy |
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. | TAS |
BP | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen |
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. | TAS |
BP | GO:1902600 | hydrogen ion transmembrane transport |
The directed movement of hydrogen ion (proton) across a membrane. | IEA |
CC | GO:0005739 | mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | IDA |
CC | GO:0005743 | mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. | TAS |
CC | GO:0016021 | integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. | IEA |
MF | GO:0004129 | cytochrome-c oxidase activity |
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. | IEA |
| Domain ID | Description |
|---|---|
IPR004202 | Cytochrome c oxidase subunit VIIc |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa00190 | Oxidative phosphorylation | KEGG |
hsa01100 | Metabolic pathways | KEGG |
hsa04260 | Cardiac muscle contraction | KEGG |
hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | KEGG |
hsa05010 | Alzheimer's disease | KEGG |
hsa05012 | Parkinson's disease | KEGG |
hsa05016 | Huntington's disease | KEGG |
WP111 | Electron Transport Chain | WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
C0028754 | Obesity |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
breast | glandular cells |
bronchus | respiratory epithelial cells |
caudate | glial cells |
cerebellum | cells in granular layer |
cerebellum | Purkinje cells |
cervix, uterine | glandular cells |
colon | glandular cells |
duodenum | glandular cells |
endometrium | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
heart muscle | myocytes |
kidney | cells in tubules |
liver | hepatocytes |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
parathyroid gland | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
seminal vesicle | glandular cells |
skin | melanocytes |
skin | epidermal cells |
small intestine | glandular cells |
stomach | glandular cells |
testis | cells in seminiferous ducts |
testis | Leydig cells |
tonsil | squamous epithelial cells |
urinary bladder | urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
CLPP | 8192 | Q16740 | 0.49 |
MT-CO2 | 4513 | P00403 | 0.58 |
MDM2 | 4193 | Q00987 | 0.63 |