| Gene Symbol | COX7C |
| Entrez ID | 1350 |
| Uniprot ID | P15954 |
| Description | cytochrome c oxidase subunit VIIc |
| Chromosomal Location | chr5: 86,617,904-86,620,962 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006091 |
generation of precursor metabolites and energy |
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. |
TAS |
|
BP |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. |
TAS |
|
BP |
GO:1902600 |
hydrogen ion transmembrane transport |
The directed movement of hydrogen ion (proton) across a membrane. |
IEA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
TAS |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0004129 |
cytochrome-c oxidase activity |
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR004202 |
Cytochrome c oxidase subunit VIIc |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00190 |
Oxidative phosphorylation |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa04260 |
Cardiac muscle contraction |
KEGG |
|
hsa04932 |
Non-alcoholic fatty liver disease (NAFLD) |
KEGG |
|
hsa05010 |
Alzheimer's disease |
KEGG |
|
hsa05012 |
Parkinson's disease |
KEGG |
|
hsa05016 |
Huntington's disease |
KEGG |
|
WP111 |
Electron Transport Chain |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0028754 |
Obesity |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
Purkinje cells |
|
cervix, uterine |
glandular cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
parathyroid gland |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CLPP |
8192 |
Q16740 |
0.49 |
|
MT-CO2 |
4513 |
P00403 |
0.58 |
|
MDM2 |
4193 |
Q00987 |
0.63 |