| Gene Symbol | YTHDF2 |
| Entrez ID | 51441 |
| Uniprot ID | Q9Y5A9 |
| Description | YTH N(6)-methyladenosine RNA binding protein 2 |
| Chromosomal Location | chr1: 28,736,621-28,769,775 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006959 |
humoral immune response |
An immune response mediated through a body fluid. |
TAS |
|
BP |
GO:0043488 |
regulation of mRNA stability |
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. |
IMP |
|
BP |
GO:1903679 |
positive regulation of cap-independent translational initiation |
Any process that activates or increases the frequency, rate or extent of cap-independent translational initiation. |
IDA |
|
CC |
GO:0000932 |
cytoplasmic mRNA processing body |
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci. |
IDA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
|
MF |
GO:1990247 |
N6-methyladenosine-containing RNA binding |
Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR007275 |
YTH domain |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cervix, uterine |
glandular cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
lung |
pneumocytes |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
17148555 |
Wood et al. |
2007 |
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
AGL |
178 |
P35573 |
0.49 |
|
HMBS |
3145 |
P08397 |
0.49 |
|
APP |
351 |
P05067 |
0.56 |
|
IRAK2 |
3656 |
O43187 |
0.63 |
|
NUP98 |
4928 |
P52948 |
0.63 |
|
SEPT7 |
989 |
Q16181 |
0.49 |
|
DCTN1 |
1639 |
Q14203 |
0.49 |
|
SFPQ |
6421 |
P23246 |
0.49 |
|
USP5 |
8078 |
P45974 |
0.49 |
|
USP13 |
8975 |
Q92995 |
0.49 |
|
ASPSCR1 |
79058 |
Q9BZE9 |
0.49 |
|
B9D2 |
80776 |
Q9BPU9 |
0.49 |
|
CEP19 |
84984 |
Q96LK0 |
0.49 |
|
BMI1 |
648 |
P35226 |
0.63 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
EPAS1 |
2034 |
Q99814 |
0.63 |
|
ESR1 |
2099 |
P03372 |
0.63 |
|
ILK |
3611 |
Q13418 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MCM2 |
4171 |
P49736 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
RNF2 |
6045 |
Q99496 |
0.63 |
|
RPA1 |
6117 |
P27694 |
0.63 |
|
RPA2 |
6118 |
P15927 |
0.63 |
|
RPA3 |
6119 |
P35244 |
0.63 |
|
RPS6KB2 |
6199 |
Q9UBS0 |
0.63 |
|
UGP2 |
7360 |
Q16851 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
EIF3A |
8661 |
Q14152 |
0.63 |
|
EIF3H |
8667 |
O15372 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
TARDBP |
23435 |
Q13148 |
0.63 |
|
POT1 |
25913 |
Q9NUX5 |
0.63 |
|
FBXO6 |
26270 |
Q9NRD1 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
FN1 |
2335 |
P02751 |
0.72 |
|
HNRNPA1 |
3178 |
P09651 |
0.72 |
|
HNRNPH1 |
3187 |
P31943 |
0.72 |
|
SMAD3 |
4088 |
P84022 |
0.72 |
|
RPL10 |
6134 |
P27635 |
0.72 |
|
MEPCE |
56257 |
Q7L2J0 |
0.72 |
|
HIPK4 |
147746 |
Q8NE63 |
0.72 |
|
VCAM1 |
7412 |
P19320 |
0.82 |