| Gene Symbol | COX5B |
| Entrez ID | 1329 |
| Uniprot ID | P10606 |
| Description | cytochrome c oxidase subunit Vb |
| Chromosomal Location | chr2: 97,646,040-97,648,383 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006123 |
mitochondrial electron transport, cytochrome c to oxygen |
The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. |
IBA|TAS |
|
BP |
GO:0007585 |
respiratory gaseous exchange |
The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. |
TAS |
|
BP |
GO:0042776 |
mitochondrial ATP synthesis coupled proton transport |
The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. |
IBA |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IDA |
|
CC |
GO:0005743 |
mitochondrial inner membrane |
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
TAS |
|
CC |
GO:0005751 |
mitochondrial respiratory chain complex IV |
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). |
IBA |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0004129 |
cytochrome-c oxidase activity |
Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0046872 |
metal ion binding |
Interacting selectively and non-covalently with any metal ion. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR002124 |
Cytochrome c oxidase, subunit Vb |
|
IPR020893 |
Cytochrome c oxidase, subunit Vb, zinc binding site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00190 |
Oxidative phosphorylation |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa04260 |
Cardiac muscle contraction |
KEGG |
|
hsa04932 |
Non-alcoholic fatty liver disease (NAFLD) |
KEGG |
|
hsa05010 |
Alzheimer's disease |
KEGG |
|
hsa05012 |
Parkinson's disease |
KEGG |
|
hsa05016 |
Huntington's disease |
KEGG |
|
WP111 |
Electron Transport Chain |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0151744 |
Myocardial Ischemia |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cerebral cortex |
neuropil |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
neuronal cells |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
DLAT |
1737 |
P10515 |
0.49 |
|
RPLP2 |
6181 |
P05387 |
0.49 |
|
PPIL3 |
53938 |
Q9H2H8 |
0.49 |
|
PDIA3 |
2923 |
P30101 |
0.63 |
|
DNAJA1 |
3301 |
P31689 |
0.63 |
|
KRT15 |
3866 |
P19012 |
0.63 |
|
KRT31 |
3881 |
Q15323 |
0.63 |
|
TRAF1 |
7185 |
Q13077 |
0.63 |
|
BHLHE40 |
8553 |
O14503 |
0.63 |
|
PNMA1 |
9240 |
Q8ND90 |
0.63 |
|
MID2 |
11043 |
Q9UJV3 |
0.63 |
|
TFIP11 |
24144 |
Q9UBB9 |
0.63 |
|
FAM208B |
54906 |
Q5VWN6 |
0.63 |
|
VPS37A |
137492 |
Q8NEZ2 |
0.63 |
|
TRIM23 |
373 |
P36406 |
0.73 |
|
CCDC36 |
339834 |
Q8IYA8 |
0.73 |
|
AP2B1 |
163 |
P63010 |
0.49 |
|
NDUFA10 |
4705 |
O95299 |
0.49 |
|
PSMD7 |
5713 |
P51665 |
0.49 |
|
CLPP |
8192 |
Q16740 |
0.49 |
|
VAPB |
9217 |
O95292 |
0.49 |
|
TOMM40 |
10452 |
O96008 |
0.49 |
|
CHCHD2 |
51142 |
Q9Y6H1 |
0.49 |
|
WDFY1 |
57590 |
Q8IWB7 |
0.49 |
|
COX5A |
9377 |
P20674 |
0.56 |
|
CDR2 |
1039 |
Q01850 |
0.63 |
|
EPB41 |
2035 |
P11171 |
0.63 |
|
HLA-E |
3133 |
P13747 |
0.63 |
|
MDM2 |
4193 |
Q00987 |
0.63 |
|
MOV10 |
4343 |
Q9HCE1 |
0.63 |
|
SHMT2 |
6472 |
P34897 |
0.63 |
|
CHAF1B |
8208 |
Q13112 |
0.63 |
|
PTBP3 |
9991 |
O95758 |
0.63 |
|
NXF1 |
10482 |
Q9UBU9 |
0.63 |
|
LSM4 |
25804 |
Q9Y4Z0 |
0.63 |
|
OTUB1 |
55611 |
Q96FW1 |
0.63 |
|
TM9SF3 |
56889 |
Q9HD45 |
0.63 |
|
HTT |
3064 |
P42858 |
0.68 |
|
MT-CO2 |
4513 |
P00403 |
0.68 |
|
RAB5C |
5878 |
P51148 |
0.72 |
|
VAPA |
9218 |
Q9P0L0 |
0.72 |
|
TIMMDC1 |
51300 |
Q9NPL8 |
0.72 |
|
NELFCD |
51497 |
Q8IXH7 |
0.72 |
|
YIPF5 |
81555 |
Q969M3 |
0.72 |
|
NDUFA11 |
126328 |
Q86Y39 |
0.72 |
|
AR |
367 |
P10275 |
0.88 |