BP

GO:0006914

autophagy

The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.

IEA

BP

GO:0006915

apoptotic process

A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.

IEA

BP

GO:0010508

positive regulation of autophagy

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

IMP

BP

GO:0016241

regulation of macroautophagy

Any process that modulates the frequency, rate or extent of macroautophagy.

TAS

BP

GO:0031647

regulation of protein stability

Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.

IMP

BP

GO:0032461

positive regulation of protein oligomerization

Any process that activates or increases the frequency, rate or extent of protein oligomerization.

IDA

BP

GO:0032465

regulation of cytokinesis

Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

IMP

BP

GO:0032801

receptor catabolic process

The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

IMP

BP

GO:0034198

cellular response to amino acid starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.

IMP

BP

GO:0042149

cellular response to glucose starvation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.

IMP

BP

GO:0048102

autophagic cell death

A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells.

IMP

BP

GO:0051259

protein oligomerization

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

IDA

BP

GO:0090148

membrane fission

A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.

IMP

BP

GO:0098609

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

IEA

BP

GO:1903527

positive regulation of membrane tubulation

Any process that activates or increases the frequency, rate or extent of membrane tubulation.

IMP

BP

GO:1903778

protein localization to vacuolar membrane

A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.

IMP

BP

GO:1903955

positive regulation of protein targeting to mitochondrion

Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.

IMP

BP

GO:2000786

positive regulation of autophagosome assembly

Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly.

IMP

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0000421

autophagosome membrane

The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005741

mitochondrial outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

IEA

CC

GO:0005913

cell-cell adherens junction

An adherens junction which connects a cell to another cell.

IDA

CC

GO:0030496

midbody

A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.

IDA

CC

GO:0031410

cytoplasmic vesicle

A vesicle found in the cytoplasm of a cell.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008289

lipid binding

Interacting selectively and non-covalently with a lipid.

IEA

MF

GO:0042802

identical protein binding

Interacting selectively and non-covalently with an identical protein or proteins.

IPI

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IPI

MF

GO:0098641

cadherin binding involved in cell-cell adhesion

Any cadherin binding that occurs as part of the process of cell-cell adhesion.

IDA