Protein Description

Gene Symbol FCF1
Entrez ID 51077
Uniprot ID Q9Y324
Description FCF1 rRNA-processing protein
Chromosomal Location chr14: 74,713,144-74,738,620
Ontology GO ID GO Term Definition Evidence

BP

GO:0000447

endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.

IEA

BP

GO:0000462

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

IBA

BP

GO:0000480

endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.

IEA

BP

GO:0006364

rRNA processing

Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

TAS

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

TAS

CC

GO:0005730

nucleolus

A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

IBA

CC

GO:0032040

small-subunit processome

A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

IBA

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR002716

PIN domain

IPR006984

rRNA-processing protein Fcf1/Utp23

IPR029060

PIN domain-like

Pathway ID Pathway Term Pathway Source

hsa03008

Ribosome biogenesis in eukaryotes

KEGG

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

bronchus

respiratory epithelial cells

cerebral cortex

neuronal cells

kidney

cells in tubules

placenta

decidual cells

rectum

glandular cells

skin

keratinocytes

testis

cells in seminiferous ducts

tonsil

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

15291743

Diao et al.

2004

The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray

Gene Symbol Entrez ID Uniprot ID Score

APP

351

P05067

0.56

HNRNPU

3192

Q00839

0.63

IFI16

3428

Q16666

0.63

MYH9

4627

P35579

0.63

RPS2

6187

P15880

0.63

TM9SF4

9777

Q92544

0.63

RBM4B

83759

Q9BQ04

0.63