Gene Symbol | FCF1 |
Entrez ID | 51077 |
Uniprot ID | Q9Y324 |
Description | FCF1 rRNA-processing protein |
Chromosomal Location | chr14: 74,713,144-74,738,620 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0000447 |
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
IEA |
BP |
GO:0000462 |
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
IBA |
BP |
GO:0000480 |
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable. |
IEA |
BP |
GO:0006364 |
rRNA processing |
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
TAS |
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IBA |
CC |
GO:0032040 |
small-subunit processome |
A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. |
IBA |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
Domain ID | Description |
---|---|
IPR002716 |
PIN domain |
IPR006984 |
rRNA-processing protein Fcf1/Utp23 |
IPR029060 |
PIN domain-like |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa03008 |
Ribosome biogenesis in eukaryotes |
KEGG |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
bronchus |
respiratory epithelial cells |
cerebral cortex |
neuronal cells |
kidney |
cells in tubules |
placenta |
decidual cells |
rectum |
glandular cells |
skin |
keratinocytes |
testis |
cells in seminiferous ducts |
tonsil |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15291743 |
Diao et al. |
2004 |
The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
APP |
351 |
P05067 |
0.56 |
HNRNPU |
3192 |
Q00839 |
0.63 |
IFI16 |
3428 |
Q16666 |
0.63 |
MYH9 |
4627 |
P35579 |
0.63 |
RPS2 |
6187 |
P15880 |
0.63 |
TM9SF4 |
9777 |
Q92544 |
0.63 |
RBM4B |
83759 |
Q9BQ04 |
0.63 |