| Gene Symbol | ZNF593 |
| Entrez ID | 51042 |
| Uniprot ID | O00488 |
| Description | zinc finger protein 593 |
| Chromosomal Location | chr1: 26,169,871-26,170,873 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
TAS |
|
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IDA |
|
MF |
GO:0003677 |
DNA binding |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
IEA |
|
MF |
GO:0003714 |
transcription corepressor activity |
Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery. |
TAS |
|
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR003604 |
Matrin/U1-C-like, C2H2-type zinc finger |
|
IPR013087 |
Zinc finger C2H2-type |
|
IPR022755 |
Zinc finger, double-stranded RNA binding |
| UMLS CUI | UMLS Term |
|---|---|
|
C0038356 |
Stomach Neoplasms |
|
C0242656 |
Disease Progression |
| Tissue | Cell Type |
|---|---|
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
adipocytes |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
chondrocytes |
|
soft tissue |
fibroblasts |
|
soft tissue |
adipocytes |
|
soft tissue |
peripheral nerve |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
GPR3 |
2827 |
P46089 |
0.63 |
|
CADPS |
8618 |
Q9ULU8 |
0.63 |
|
LNX1 |
84708 |
Q8TBB1 |
0.63 |
|
ATP6V1A |
523 |
P38606 |
0.49 |
|
LTA4H |
4048 |
P09960 |
0.49 |
|
PFAS |
5198 |
O15067 |
0.49 |
|
SDC1 |
6382 |
P18827 |
0.49 |
|
UCHL3 |
7347 |
P15374 |
0.49 |
|
USP5 |
8078 |
P45974 |
0.49 |
|
USO1 |
8615 |
O60763 |
0.49 |
|
PRDX4 |
10549 |
Q13162 |
0.49 |
|
DNPH1 |
10591 |
O43598 |
0.49 |
|
SEC23IP |
11196 |
Q9Y6Y8 |
0.49 |
|
NUDCD2 |
134492 |
Q8WVJ2 |
0.49 |
|
UBR1 |
197131 |
Q8IWV7 |
0.49 |
|
SRPK2 |
6733 |
P78362 |
0.52 |
|
SSB |
6741 |
P05455 |
0.56 |
|
RAB1A |
5861 |
P62820 |
0.63 |
|
MAP3K7 |
6885 |
O43318 |
0.63 |
|
MAPK8IP2 |
23542 |
Q13387 |
0.63 |
|
ZNRD1 |
30834 |
Q9P1U0 |
0.63 |
|
ZAK |
51776 |
Q9NYL2 |
0.63 |