Gene Symbol | PNPLA8 |
Entrez ID | 50640 |
Uniprot ID | Q9NP80 |
Description | patatin like phospholipase domain containing 8 |
Chromosomal Location | chr7: 108,470,422-108,569,666 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001516 |
prostaglandin biosynthetic process |
The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring. |
IDA |
BP |
GO:0006631 |
fatty acid metabolic process |
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. |
IDA |
BP |
GO:0008219 |
cell death |
Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). |
IDA |
BP |
GO:0019369 |
arachidonic acid metabolic process |
The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. |
IDA |
BP |
GO:0034638 |
phosphatidylcholine catabolic process |
The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
IDA |
BP |
GO:0036151 |
phosphatidylcholine acyl-chain remodeling |
Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. |
TAS |
BP |
GO:0036152 |
phosphatidylethanolamine acyl-chain remodeling |
Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. |
TAS |
BP |
GO:0043651 |
linoleic acid metabolic process |
The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2. |
IDA |
BP |
GO:0046338 |
phosphatidylethanolamine catabolic process |
The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
IDA |
BP |
GO:0050482 |
arachidonic acid secretion |
The controlled release of arachidonic acid from a cell or a tissue. |
IDA |
CC |
GO:0000139 |
Golgi membrane |
The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
IEA |
CC |
GO:0005622 |
intracellular |
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. |
IDA |
CC |
GO:0005777 |
peroxisome |
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
IDA |
CC |
GO:0005778 |
peroxisomal membrane |
The lipid bilayer surrounding a peroxisome. |
IDA |
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
TAS |
CC |
GO:0016020 |
membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
IDA |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IEA |
MF |
GO:0004622 |
lysophospholipase activity |
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. |
IEA |
MF |
GO:0004623 |
phospholipase A2 activity |
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. |
TAS |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
NAS |
MF |
GO:0047499 |
calcium-independent phospholipase A2 activity |
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. |
IDA |
Domain ID | Description |
---|---|
IPR002641 |
Patatin-like phospholipase domain |
IPR016035 |
Acyl transferase/acyl hydrolase/lysophospholipase |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
WP167 |
Eicosanoid Synthesis |
WikiPathways |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
appendix |
glandular cells |
bronchus |
respiratory epithelial cells |
caudate |
neuronal cells |
cerebellum |
cells in granular layer |
cerebellum |
cells in molecular layer |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
glandular cells |
epididymis |
glandular cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
hippocampus |
neuronal cells |
kidney |
cells in tubules |
lung |
macrophages |
lung |
pneumocytes |
lymph node |
non-germinal center cells |
ovary |
follicle cells |
pancreas |
exocrine glandular cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
rectum |
glandular cells |
seminal vesicle |
glandular cells |
small intestine |
glandular cells |
soft tissue |
fibroblasts |
stomach |
glandular cells |
thyroid gland |
glandular cells |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
HNRNPD |
3184 |
Q14103 |
0.72 |
BAG6 |
7917 |
P46379 |
0.72 |
KAT6A |
7994 |
Q92794 |
0.72 |
SYNCRIP |
10492 |
O60506 |
0.72 |
PLK4 |
10733 |
O00444 |
0.72 |
SIN3B |
23309 |
O75182 |
0.72 |
SGTB |
54557 |
Q96EQ0 |
0.72 |