Protein Description

Gene Symbol PNPLA8
Entrez ID 50640
Uniprot ID Q9NP80
Description patatin like phospholipase domain containing 8
Chromosomal Location chr7: 108,470,422-108,569,666
Ontology GO ID GO Term Definition Evidence

BP

GO:0001516

prostaglandin biosynthetic process

The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.

IDA

BP

GO:0006631

fatty acid metabolic process

The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

IDA

BP

GO:0008219

cell death

Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).

IDA

BP

GO:0019369

arachidonic acid metabolic process

The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.

IDA

BP

GO:0034638

phosphatidylcholine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

IDA

BP

GO:0036151

phosphatidylcholine acyl-chain remodeling

Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.

TAS

BP

GO:0036152

phosphatidylethanolamine acyl-chain remodeling

Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.

TAS

BP

GO:0043651

linoleic acid metabolic process

The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.

IDA

BP

GO:0046338

phosphatidylethanolamine catabolic process

The chemical reactions and pathways resulting in the breakdown of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

IDA

BP

GO:0050482

arachidonic acid secretion

The controlled release of arachidonic acid from a cell or a tissue.

IDA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

IEA

CC

GO:0005622

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

IDA

CC

GO:0005777

peroxisome

A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

IDA

CC

GO:0005778

peroxisomal membrane

The lipid bilayer surrounding a peroxisome.

IDA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IEA

MF

GO:0004622

lysophospholipase activity

Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

IEA

MF

GO:0004623

phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.

TAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

NAS

MF

GO:0047499

calcium-independent phospholipase A2 activity

Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.

IDA

Domain ID Description

IPR002641

Patatin-like phospholipase domain

IPR016035

Acyl transferase/acyl hydrolase/lysophospholipase

Pathway ID Pathway Term Pathway Source

WP167

Eicosanoid Synthesis

WikiPathways

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

bronchus

respiratory epithelial cells

caudate

neuronal cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

neuronal cells

kidney

cells in tubules

lung

macrophages

lung

pneumocytes

lymph node

non-germinal center cells

ovary

follicle cells

pancreas

exocrine glandular cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

seminal vesicle

glandular cells

small intestine

glandular cells

soft tissue

fibroblasts

stomach

glandular cells

thyroid gland

glandular cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

HNRNPD

3184

Q14103

0.72

BAG6

7917

P46379

0.72

KAT6A

7994

Q92794

0.72

SYNCRIP

10492

O60506

0.72

PLK4

10733

O00444

0.72

SIN3B

23309

O75182

0.72

SGTB

54557

Q96EQ0

0.72