Protein Description

Gene Symbol COL4A6
Entrez ID 1288
Uniprot ID Q14031
Description collagen, type IV, alpha 6
Chromosomal Location chrX: 108,155,607-108,439,497
Ontology GO ID GO Term Definition Evidence

BP

GO:0007155

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

IEA

BP

GO:0030198

extracellular matrix organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.

TAS

BP

GO:0030574

collagen catabolic process

The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.

TAS

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

TAS

CC

GO:0005587

collagen type IV trimer

A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.

NAS

CC

GO:0005788

endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.

TAS

MF

GO:0005201

extracellular matrix structural constituent

The action of a molecule that contributes to the structural integrity of the extracellular matrix.

IEA

Domain ID Description

IPR001442

Collagen IV, non-collagenous

IPR008160

Collagen triple helix repeat

IPR016187

C-type lectin fold

Pathway ID Pathway Term Pathway Source

hsa04151

PI3K-Akt signaling pathway

KEGG

hsa04510

Focal adhesion

KEGG

hsa04512

ECM-receptor interaction

KEGG

hsa04933

AGE-RAGE signaling pathway in diabetic complications

KEGG

hsa04974

Protein digestion and absorption

KEGG

hsa05146

Amoebiasis

KEGG

hsa05200

Pathways in cancer

KEGG

hsa05222

Small cell lung cancer

KEGG

WP306

Focal Adhesion

WikiPathways

WP3932

Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

WikiPathways

h_amiPathway

Acute Myocardial Infarction

BioCarta

h_ace2Pathway

Angiotensin-converting enzyme 2 regulates heart function

BioCarta

h_intrinsicPathway

Intrinsic Prothrombin Activation Pathway

BioCarta

h_plateletAppPathway

Platelet Amyloid Precursor Protein Pathway

BioCarta

h_npp1Pathway

Regulators of Bone Mineralization

BioCarta

h_vitCBPathway

Vitamin C in the Brain

BioCarta

UMLS CUI UMLS Term

C0000786

Spontaneous Abortion

C0086533

Leiomyoma, Epithelioid

No tissues found.

No databases found.

Pubmed ID Author Year Title

15308691

Jansen et al.

2004

Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients

Gene Symbol Entrez ID Uniprot ID Score

SUMF1

285362

Q8NBK3

0.49

FN1

2335

P02751

0.52

DCN

1634

P07585

0.62

FBLN2

2199

P98095

0.62

MMP9

4318

P14780

0.62

SERPINE2

5270

P07093

0.62

CD93

22918

Q9NPY3

0.65

OSM

5008

P13725

0.66

KLK6

5653

Q92876

0.68

APP

351

P05067

0.70

COL4A5

1287

P29400

0.52

HABP2

3026

Q14520

0.52

MATN2

4147

O00339

0.62

VHL

7428

P40337

0.63