Protein Description

Gene Symbol CARD10
Entrez ID 29775
Uniprot ID Q9BWT7
Description caspase recruitment domain family member 10
Chromosomal Location chr22: 37,490,362-37,519,542
Ontology GO ID GO Term Definition Evidence

BP

GO:0006461

protein complex assembly

The aggregation, arrangement and bonding together of a set of components to form a protein complex.

NAS

BP

GO:0007250

activation of NF-kappaB-inducing kinase activity

The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.

IDA|ISS

BP

GO:0042981

regulation of apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

NAS

CC

GO:0032449

CBM complex

A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation.

NAS

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0030159

receptor signaling complex scaffold activity

Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.

NAS

Domain ID Description

IPR001315

CARD domain

IPR011029

Death-like domain

Pathway ID Pathway Term Pathway Source

hsa04064

NF-kappa B signaling pathway

KEGG

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

glial cells

cerebellum

cells in granular layer

cerebellum

Purkinje cells

cervix, uterine

glandular cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

epididymis

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

kidney

cells in tubules

liver

hepatocytes

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

pancreas

exocrine glandular cells

parathyroid gland

glandular cells

prostate

glandular cells

rectum

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skin

fibroblasts

small intestine

glandular cells

spleen

cells in white pulp

stomach

glandular cells

thyroid gland

glandular cells

No databases found.

Pubmed ID Author Year Title

19141487

Kenigsberg et al.

2009

Gene expression microarray profiles of cumulus cells in lean and overweightobese polycystic ovary syndrome patients

Gene Symbol Entrez ID Uniprot ID Score

CARD10

29775

Q9BWT7

0.63

KLHL12

59349

Q53G59

0.63

IKBKG

8517

Q9Y6K9

0.76

BCL10

8915

O95999

0.90

CDC5L

988

Q99459

0.63

ATXN7

6314

O15265

0.63

GFOD1

54438

Q9NXC2

0.63

CAPZA2

830

P47755

0.72

DBN1

1627

Q16643

0.72

MYO1C

4641

O00159

0.72

KIF20A

10112

O95235

0.72

MYO19

80179

Q96H55

0.72