PCOSBase

Protein Description

Ontology	GO ID	GO Term	Definition	Evidence
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA\|ISS
CC	GO:0005730	nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	IDA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA

Domain ID	Description
IPR002740	EVE domain
IPR015947	PUA-like domain

UMLS CUI	UMLS Term
C0033578	Prostatic Neoplasms

Tissue	Cell Type
adrenal gland	glandular cells
bone marrow	hematopoietic cells
breast	adipocytes
breast	glandular cells
breast	myoepithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	cells in molecular layer
cerebral cortex	endothelial cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
colon	glandular cells
duodenum	glandular cells
endometrium	cells in endometrial stroma
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
hippocampus	glial cells
kidney	cells in tubules
lung	macrophages
lung	pneumocytes
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
placenta	decidual cells
placenta	trophoblastic cells
rectum	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
smooth muscle	smooth muscle cells
soft tissue	adipocytes
soft tissue	chondrocytes
soft tissue	fibroblasts
soft tissue	peripheral nerve
spleen	cells in red pulp
testis	Leydig cells
thyroid gland	glandular cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

Pubmed ID	Author	Year	Title
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol	Entrez ID	Uniprot ID	Score
GOLGA2	2801	Q08379	0.63
PRKDC	5591	P78527	0.49
THOC2	57187	Q8NI27	0.49
JUN	3725	P05412	0.63
NTRK1	4914	P04629	0.63
TFAP4	7023	Q01664	0.63