PCOSBase

Protein Description

Gene Symbol	MED4
Entrez ID	29079
Uniprot ID	Q9NPJ6
Description	mediator complex subunit 4
Chromosomal Location	chr13: 48,053,323-48,095,131

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0006357	regulation of transcription from RNA polymerase II promoter	Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.	IEA
BP	GO:0006366	transcription from RNA polymerase II promoter	The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).	IDA
BP	GO:0006367	transcription initiation from RNA polymerase II promoter	Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.	IDA\|TAS
BP	GO:0030518	intracellular steroid hormone receptor signaling pathway	A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.	IDA
BP	GO:0030521	androgen receptor signaling pathway	Any series of molecular signals generated as a consequence of an androgen binding to its receptor.	IDA
BP	GO:0045893	positive regulation of transcription, DNA-templated	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.	IDA
CC	GO:0005634	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	IDA
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA\|TAS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0016592	mediator complex	A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.	IDA
CC	GO:0070847	core mediator complex	A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.	IBA
MF	GO:0001104	RNA polymerase II transcription cofactor activity	Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.	IDA
MF	GO:0003712	transcription cofactor activity	Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.	IDA
MF	GO:0004872	receptor activity	Combining with an extracellular or intracellular messenger to initiate a change in cell activity.	IDA
MF	GO:0005515	protein binding	Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	IPI
MF	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.	NAS
MF	GO:0042809	vitamin D receptor binding	Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.	NAS
MF	GO:0046966	thyroid hormone receptor binding	Interacting selectively and non-covalently with a thyroid hormone receptor.	IDA

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Domain ID	Description
IPR019258	Mediator complex, subunit Med4

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Pathway ID	Pathway Term	Pathway Source
hsa04919	Thyroid hormone signaling pathway	KEGG

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UMLS CUI	UMLS Term
C0014175	Endometriosis

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Tissue	Cell Type
adrenal gland	glandular cells
caudate	glial cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	neuronal cells
lung	macrophages
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
placenta	decidual cells
placenta	trophoblastic cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	epidermal cells
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
17148555	Wood et al.	2007	Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis
26459919	Lan et al.	2015	Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

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Gene Symbol	Entrez ID	Uniprot ID	Score
ADSL	158	P30566	0.49
DST	667	Q03001	0.49
BUB1B	701	O60566	0.49
LRBA	987	P50851	0.49
CYLD	1540	Q9NQC7	0.49
DBT	1629	P11182	0.49
DPYSL3	1809	Q14195	0.49
DVL2	1856	O14641	0.49
EPB41	2035	P11171	0.49
FLNB	2317	O75369	0.49
KIF5A	3798	Q12840	0.49
KIF5B	3799	P33176	0.49
KIF11	3832	P52732	0.49
MAP1B	4131	P46821	0.49
NBN	4683	O60934	0.49
PCNT	5116	O95613	0.49
POLR2A	5430	P24928	0.49
PSMA2	5683	P25787	0.49
PSMB1	5689	P20618	0.49
PSMD7	5713	P51665	0.49
SNX1	6642	Q13596	0.49
SRP68	6730	Q9UHB9	0.49
TLN1	7094	Q9Y490	0.49
TP53BP2	7159	Q13625	0.49
UTRN	7402	P46939	0.49
TRIM25	7706	Q14258	0.49
ZYX	7791	Q15942	0.49
LUZP1	7798	Q86V48	0.49
ALMS1	7840	Q8TCU4	0.49
OFD1	8481	O75665	0.49
SQSTM1	8878	Q13501	0.49
SPAG9	9043	O60271	0.49
DLG5	9231	Q8TDM6	0.49
CLINT1	9685	Q14677	0.49
SLK	9748	Q9H2G2	0.49
ZFYVE16	9765	Q7Z3T8	0.49
CKAP5	9793	Q14008	0.49
KEAP1	9817	Q14145	0.49
CEP350	9857	Q5VT06	0.49
CEP170	9859	Q5SW79	0.49
KIF14	9928	Q15058	0.49
USP15	9958	Q9Y4E8	0.49
ACTR1A	10121	P61163	0.49
PDIA6	10130	Q15084	0.49
MPHOSPH9	10198	Q99550	0.49
PIBF1	10464	Q8WXW3	0.49
EIF3M	10480	Q7L2H7	0.49
DCTN2	10540	Q13561	0.49
PAICS	10606	P22234	0.49
PDLIM5	10611	Q96HC4	0.49
SPAG5	10615	Q96R06	0.49
SDCCAG3	10807	Q96C92	0.49
FGFR1OP	11116	O95684	0.49
KIF3A	11127	Q9Y496	0.49
DCTN3	11258	O75935	0.49
ECD	11319	O95905	0.49
ANKRD26	22852	Q9UPS8	0.49
CEP131	22994	Q9UPN4	0.49
CEP152	22995	O94986	0.49
CNOT1	23019	A5YKK6	0.49
MYCBP2	23077	O75592	0.49
ERC1	23085	Q8IUD2	0.49
TTLL5	23093	Q6EMB2	0.49
EPB41L3	23136	Q9Y2J2	0.49
TTC28	23331	Q96AY4	0.49
HAUS5	23354	O94927	0.49
MED13L	23389	Q71F56	0.49
SCRIB	23513	Q14160	0.49
CD2AP	23607	Q9Y5K6	0.49
EDC4	23644	Q6P2E9	0.49
IFIT5	24138	Q13325	0.49
CNOT10	25904	Q9H9A5	0.49
KANK2	25959	Q63ZY3	0.49
C2CD3	26005	Q4AC94	0.49
RAI14	26064	Q9P0K7	0.49
EDRF1	26098	Q3B7T1	0.49
CCDC22	28952	O60826	0.49
IFT81	28981	Q8WYA0	0.49
TBK1	29110	Q9UHD2	0.49
WRAP73	49856	Q9P2S5	0.49
NIN	51199	Q8N4C6	0.49
CPSF3	51692	Q9UKF6	0.49
RBM11	54033	P57052	0.49
XRN1	54464	Q8IZH2	0.49
HAUS6	54801	Q7Z4H7	0.49
HAUS4	54930	Q9H6D7	0.49
ATG2B	55102	Q96BY7	0.49
HAUS2	55142	Q9NVX0	0.49
CEP55	55165	Q53EZ4	0.49
HAUS7	55559	Q99871	0.49
CNOT11	55571	Q9UKZ1	0.49
DENND4C	55667	Q5VZ89	0.49
CEP72	55722	Q9P209	0.49
ERBB2IP	55914	Q96RT1	0.49
NSFL1C	55968	Q9UNZ2	0.49
SH3GLB2	56904	Q9NR46	0.49
ODF2L	57489	Q9ULJ1	0.49
MIB1	57534	Q86YT6	0.49
MICAL3	57553	Q7RTP6	0.49
KIAA1524	57650	Q8TCG1	0.49
SHTN1	57698	A0MZ66	0.49
EPS15L1	58513	Q9UBC2	0.49
EXOC4	60412	Q96A65	0.49
UBE2O	63893	Q9C0C9	0.49
CCDC14	64770	Q49A88	0.49
WNK1	65125	Q9H4A3	0.49
AHNAK	79026	Q09666	0.49
HAUS3	79441	Q68CZ6	0.49
MAP7D3	79649	Q8IWC1	0.49
CSPP1	79848	Q1MSJ5	0.49
IFT74	80173	Q96LB3	0.49
TCHP	84260	Q9BT92	0.49
CCDC77	84318	Q9BR77	0.49
NIFK	84365	Q9BYG3	0.49
NEK9	91754	Q8TD19	0.49
HAUS8	93323	Q9BT25	0.49
TBC1D31	93594	Q96DN5	0.49
CNTROB	116840	Q8N137	0.49
SSX2IP	117178	Q9Y2D8	0.49
LSM12	124801	Q3MHD2	0.49
SPC24	147841	Q8NBT2	0.49
CAMSAP1	157922	Q5T5Y3	0.49
WDR90	197335	Q96KV7	0.49
SKA3	221150	Q8IX90	0.49
CCDC66	285331	A2RUB6	0.49
CCDC18	343099	Q5T9S5	0.49
FAM101B	359845	Q8N5W9	0.49
FAM111B	374393	Q6SJ93	0.49
KIF7	374654	Q2M1P5	0.49
CCDC61	729440	Q9Y6R9	0.49
NAV1	730426	Q8NEY1	0.49
FAM91A1	157769	Q658Y4	0.56
ODF2	4957	Q5BJF6	0.59
CEP135	9662	Q66GS9	0.59
KIAA0753	9851	Q2KHM9	0.59
SPICE1	152185	Q8N0Z3	0.59
A2M	2	P01023	0.63
AP2A1	160	O95782	0.63
ALB	213	P02768	0.63
AMD1	262	P17707	0.63
APLP1	333	P51693	0.63
APLP2	334	Q06481	0.63
APP	351	P05067	0.63
ARRB2	409	P32121	0.63
ATP5C1	509	P36542	0.63
ATP5F1	515	P24539	0.63
ATP6V1B2	526	P21281	0.63
C3	718	P01024	0.63
CP	1356	P00450	0.63
CSNK2A2	1459	P19784	0.63
ERCC3	2071	P19447	0.63
F5	2153	P12259	0.63
FLII	2314	Q13045	0.63
GLUD2	2747	P49448	0.63
GNAO1	2775	P09471	0.63
GTF2B	2959	Q00403	0.63
GTF2F1	2962	P35269	0.63
HADHA	3030	P40939	0.63
HADHB	3032	P55084	0.63
HBA1 HBA2	3039	P69905	0.63
HBB	3043	P68871	0.63
HPX	3263	P02790	0.63
DNAJB1	3337	P25685	0.63
KARS	3735	Q15046	0.63
NOP2	4839	P46087	0.63
PI4KA	5297	P42356	0.63
PIP4K2A	5305	P48426	0.63
PMAIP1	5366	Q13794	0.63
POLR2B	5431	P30876	0.63
RAB5A	5868	P20339	0.63
SCO1	6341	O75880	0.63
SRSF5	6430	Q13243	0.63
SNRPG	6637	P62308	0.63
SPTAN1	6709	Q13813	0.63
MAP3K7	6885	O43318	0.63
TCEA1	6917	P23193	0.63
XRCC4	7518	Q13426	0.63
MOGS	7841	Q13724	0.63
MANF	7873	P55145	0.63
BAG6	7917	P46379	0.63
PIP5K1A	8394	Q99755	0.63
PIP4K2B	8396	P78356	0.63
RAE1	8480	P78406	0.63
RRP1	8568	P56182	0.63
SSNA1	8636	O43805	0.63
ARHGEF7	8874	Q14155	0.63
TAX1BP1	8887	Q86VP1	0.63
FAM50A	9130	Q14320	0.63
SNAP29	9342	O95721	0.63
CRIPT	9419	Q9P021	0.63
HOMER1	9456	Q86YM7	0.63
ARHGEF6	9459	Q15052	0.63
EEF1E1	9521	O43324	0.63
DZIP3	9666	Q86Y13	0.63
BCLAF1	9774	Q9NYF8	0.63
GIT2	9815	Q14161	0.63
UBAP2L	9898	Q14157	0.63
THRAP3	9967	Q9Y2W1	0.63
PDCD6	10016	O75340	0.63
RANBP9	10048	Q96S59	0.63
TXNDC9	10190	O14530	0.63
PSME3	10197	P61289	0.63
SRRM1	10250	Q8IYB3	0.63
RBM14	10432	Q96PK6	0.63
ATP5H	10476	O75947	0.63
CAP2	10486	P40123	0.63
KAT5	10524	Q92993	0.63
NOP56	10528	O00567	0.63
RNPS1	10921	Q15287	0.63
SUPT16H	11198	Q9Y5B9	0.63
PDAP1	11333	Q13442	0.63
EXOSC8	11340	Q96B26	0.63
FOXJ3	22887	Q9UPW0	0.63
WDTC1	23038	Q8N5D0	0.63
TNRC6B	23112	Q9UPQ9	0.63
MESDC2	23184	Q14696	0.63
PUM2	23369	Q8TB72	0.63
ACAP2	23527	Q15057	0.63
CORO1C	23603	Q9ULV4	0.63
HSPBP1	23640	Q9NZL4	0.63
QPCT	25797	Q16769	0.63
RSL1D1	26156	O76021	0.63
ZNF638	27332	Q14966	0.63
GIT1	28964	Q9Y2X7	0.63
SEC61A1	29927	P61619	0.63
MED31	51003	Q9Y3C7	0.63
MRPS17	51373	Q9Y2R5	0.63
LARP7	51574	Q4G0J3	0.63
CYCS	54205	P99999	0.63
RBM27	54439	Q9P2N5	0.63
CCHCR1	54535	Q8TD31	0.63
BRIX1	55299	Q8TDN6	0.63
WDR33	55339	Q9C0J8	0.63
ATF7IP	55729	Q6VMQ6	0.63
CCAR1	55749	Q8IX12	0.63
EXOC1	55763	Q9NV70	0.63
TXLNG	55787	Q9NUQ3	0.63
ZC3H15	55854	Q8WU90	0.63
CTNNBL1	56259	Q8WYA6	0.63
THOC2	57187	Q8NI27	0.63
LRRC47	57470	Q8N1G4	0.63
NUFIP2	57532	Q7Z417	0.63
CCDC146	57639	Q8IYE0	0.63
NCAPG	64151	Q9BPX3	0.63
RSRC2	65117	Q7L4I2	0.63
DHX40	79665	Q8IX18	0.63
PIP4K2C	79837	Q8TBX8	0.63
CPSF7	79869	Q8N684	0.63
MOB2	81532	Q70IA6	0.63
FIP1L1	81608	Q6UN15	0.63
RIOK1	83732	Q9BRS2	0.63
USHBP1	83878	Q8N6Y0	0.63
PCBD2	84105	Q9H0N5	0.63
GLYR1	84656	Q49A26	0.63
MRRF	92399	Q96E11	0.63
MRFAP1	93621	Q9Y605	0.63
ATPIF1	93974	Q9UII2	0.63
SGF29	112869	Q96ES7	0.63
FRMD6	122786	Q96NE9	0.63
C1orf216	127703	Q8TAB5	0.63
ZMAT2	153527	Q96NC0	0.63
SDE2	163859	Q6IQ49	0.63
CCDC138	165055	Q96M89	0.63
SKA1	220134	Q96BD8	0.63
FAM13C	220965	Q8NE31	0.63
SERF1A	728492	O75920	0.63
CDK11A	728642	Q9UQ88	0.63
TNFAIP8	25816	O95379	0.73
HAUS1	115106	Q96CS2	0.73
MED6	10001	O75586	0.74
MED18	54797	Q9BUE0	0.74
MED8	112950	Q96G25	0.74
MED17	9440	Q9NVC6	0.79
PCM1	5108	Q15154	0.82
MED23	9439	Q9ULK4	0.82
CEP162	22832	Q5TB80	0.82
CEP290	80184	O15078	0.82
IFT20	90410	Q8IY31	0.82
AMOT	154796	Q4VCS5	0.82
TXLNA	200081	P40222	0.82
MED13	9969	Q9UHV7	0.83
MED12	9968	Q93074	0.87
MED9	55090	Q9NWA0	0.89
EWSR1	2130	Q01844	0.49
PPM1G	5496	O15355	0.49
HUWE1	10075	Q7Z6Z7	0.49
CNTRL	11064	Q7Z7A1	0.49
AHI1	54806	Q8N157	0.49
CEP63	80254	Q96MT8	0.49
CEP89	84902	Q96ST8	0.49
POC5	134359	Q8NA72	0.49
CEP128	145508	Q6ZU80	0.49
CEP120	153241	Q8N960	0.49
SASS6	163786	Q6UVJ0	0.49
LCA5	167691	Q86VQ0	0.49
ESR1	2099	P03372	0.56
RARA	5914	P10276	0.56
CTDP1	9150	Q9Y5B0	0.56
AES	166	Q08117	0.63
CDC5L	988	Q99459	0.63
ELAVL1	1994	Q15717	0.63
EMD	2010	P50402	0.63
EPAS1	2034	Q99814	0.63
KIFC3	3801	Q9BVG8	0.63
RPA1	6117	P27694	0.63
RPA2	6118	P15927	0.63
RPA3	6119	P35244	0.63
SDCBP	6386	O00560	0.63
SEC13	6396	P55735	0.63
SMARCE1	6605	Q969G3	0.63
TADA2A	6871	O75478	0.63
VDR	7421	P11473	0.63
LRRFIP1	9208	Q32MZ4	0.63
COPS2	9318	P61201	0.63
TRIP4	9325	Q15650	0.63
QKI	9444	Q96PU8	0.63
TCL1B	9623	O95988	0.63
NR1I3	9970	Q14994	0.63
SSX3	10214	Q99909	0.63
MCRS1	10445	Q96EZ8	0.63
NXF1	10482	Q9UBU9	0.63
FTCD	10841	O95954	0.63
SNW1	22938	Q13573	0.63
ZC3H13	23091	Q5T200	0.63
NDE1	54820	Q9NXR1	0.63
OBFC1	79991	Q9H668	0.63
ESR2	2100	Q92731	0.67
KRAS	3845	P01116	0.72
MYH11	4629	P35749	0.72
POLR2G	5436	P62487	0.72
KIF21B	23046	O75037	0.72
CCNC	892	P24863	0.73
AP2M1	1173	Q96CW1	0.73
SMARCD1	6602	Q96GM5	0.73
MED7	9443	O43513	0.73
MED20	9477	Q9H944	0.73
NDC80	10403	O14777	0.73
MED15	51586	Q96RN5	0.73
FBXW7	55294	Q969H0	0.73
MED22	6837	Q15528	0.74
MED14	9282	O60244	0.74
MED27	9442	Q6P2C8	0.74
MED24	9862	O75448	0.74
MED16	10025	Q9Y2X0	0.74
MED11	400569	Q9P086	0.80
RPAP2	79871	Q8IXW5	0.82
MED21	9412	Q13503	0.83
MED28	80306	Q9H204	0.83
CDK19	23097	Q9BWU1	0.86
CDK8	1024	P49336	0.87
MED1	5469	Q15648	0.87
MED26	9441	O95402	0.87
MED30	90390	Q96HR3	0.87
MED25	81857	Q71SY5	0.88
MED29	55588	Q9NX70	0.89
MED19	219541	A0JLT2	0.89
MED10	84246	Q9BTT4	0.90
MAB21L3	126868	Q8N8X9	0.49