| Gene Symbol | CPAMD8 |
| Entrez ID | 27151 |
| Uniprot ID | Q8IZJ3 |
| Description | C3 and PZP-like, alpha-2-macroglobulin domain containing 8 |
| Chromosomal Location | chr19: 16,892,947-17,026,815 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0010951 | negative regulation of endopeptidase activity |
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins. | IEA |
CC | GO:0005615 | extracellular space |
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. | IEA |
CC | GO:0005886 | plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. | IEA |
MF | GO:0004867 | serine-type endopeptidase inhibitor activity |
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. | IEA |
| Domain ID | Description |
|---|---|
IPR001599 | Alpha-2-macroglobulin |
IPR002350 | Kazal domain |
IPR002890 | Alpha-2-macroglobulin, N-terminal |
IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
IPR009048 | Alpha-macroglobulin, receptor-binding |
IPR011625 | Alpha-2-macroglobulin, N-terminal 2 |
IPR011626 | Alpha-macroglobulin complement component |
IPR013783 | Immunoglobulin-like fold |
IPR014756 | Immunoglobulin E-set |
IPR019565 | Alpha-2-macroglobulin, thiol-ester bond-forming |
IPR019742 | Alpha-2-macroglobulin, conserved site |
IPR022041 | Farnesoic acid O-methyl transferase |
| UMLS CUI | UMLS Term |
|---|---|
C0009404 | Colorectal Neoplasms |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
breast | glandular cells |
breast | myoepithelial cells |
bronchus | respiratory epithelial cells |
cerebellum | Purkinje cells |
endometrium | glandular cells |
epididymis | glandular cells |
heart muscle | myocytes |
kidney | cells in tubules |
lung | macrophages |
nasopharynx | respiratory epithelial cells |
parathyroid gland | glandular cells |
placenta | decidual cells |
placenta | trophoblastic cells |
prostate | glandular cells |
seminal vesicle | glandular cells |
skin | melanocytes |
soft tissue | adipocytes |
testis | cells in seminiferous ducts |
testis | Leydig cells |
thyroid gland | glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
DPP4 | 1803 | P27487 | 0.52 |
SCTR | 6344 | P47872 | 0.67 |
ADCYAP1 | 116 | P18509 | 0.63 |