Protein Description

Gene Symbol ELP4
Entrez ID 26610
Uniprot ID Q96EB1
Description elongator acetyltransferase complex subunit 4
Chromosomal Location chr11: 31,509,700-31,790,328
Ontology GO ID GO Term Definition Evidence

BP

GO:0006357

regulation of transcription from RNA polymerase II promoter

Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.

IDA|TAS

BP

GO:0006368

transcription elongation from RNA polymerase II promoter

The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.

TAS

BP

GO:0043966

histone H3 acetylation

The modification of histone H3 by the addition of an acetyl group.

IDA

BP

GO:0043967

histone H4 acetylation

The modification of histone H4 by the addition of an acetyl group.

IDA

BP

GO:0045859

regulation of protein kinase activity

Any process that modulates the frequency, rate or extent of protein kinase activity.

IEA

CC

GO:0000123

histone acetyltransferase complex

A protein complex that possesses histone acetyltransferase activity.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0008023

transcription elongation factor complex

Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.

IDA

CC

GO:0033588

Elongator holoenzyme complex

A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes.

IDA

MF

GO:0000993

RNA polymerase II core binding

Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.

IDA

MF

GO:0004402

histone acetyltransferase activity

Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008607

phosphorylase kinase regulator activity

Modulation of the activity of the enzyme phosphorylase kinase.

IDA

Domain ID Description

IPR008728

Elongator complex protein 4

Pathway ID Pathway Term Pathway Source

WP2857

Mesodermal Commitment Pathway

WikiPathways

WP2853

Endoderm Differentiation

WikiPathways

UMLS CUI UMLS Term

C0003076

Aniridia

C0017601

Glaucoma

Tissue Cell Type

adrenal gland

glandular cells

appendix

glandular cells

cerebellum

Purkinje cells

cerebral cortex

neuronal cells

colon

glandular cells

duodenum

glandular cells

endometrium

glandular cells

gallbladder

glandular cells

kidney

cells in glomeruli

liver

hepatocytes

prostate

glandular cells

rectum

glandular cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

SF3B3

23450

Q15393

0.49

SRP68

6730

Q9UHB9

0.63

ELP5

23587

Q8TE02

0.72

ELP6

54859

Q0PNE2

0.82

ID2

3398

Q02363

0.63

PPP1CC

5501

P36873

0.63

SHMT2

6472

P34897

0.63

CIAO1

9391

O76071

0.63

HINFP

25988

Q9BQA5

0.63

PIPOX

51268

Q9P0Z9

0.63

FAM96B

51647

Q9Y3D0

0.63

MMS19

64210

Q96T76

0.63

CBX6

23466

O95503

0.72

ELP3

55140

Q9H9T3

0.89

ELP2

55250

Q6IA86

0.89

IKBKAP

8518

O95163

0.96