| Gene Symbol | ELP4 |
| Entrez ID | 26610 |
| Uniprot ID | Q96EB1 |
| Description | elongator acetyltransferase complex subunit 4 |
| Chromosomal Location | chr11: 31,509,700-31,790,328 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. | IDA|TAS |
BP | GO:0006368 | transcription elongation from RNA polymerase II promoter |
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. | TAS |
BP | GO:0043966 | histone H3 acetylation |
The modification of histone H3 by the addition of an acetyl group. | IDA |
BP | GO:0043967 | histone H4 acetylation |
The modification of histone H4 by the addition of an acetyl group. | IDA |
BP | GO:0045859 | regulation of protein kinase activity |
Any process that modulates the frequency, rate or extent of protein kinase activity. | IEA |
CC | GO:0000123 | histone acetyltransferase complex |
A protein complex that possesses histone acetyltransferase activity. | IDA |
CC | GO:0005654 | nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. | IDA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IDA |
CC | GO:0008023 | transcription elongation factor complex |
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. | IDA |
CC | GO:0033588 | Elongator holoenzyme complex |
A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. | IDA |
MF | GO:0000993 | RNA polymerase II core binding |
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. | IDA |
MF | GO:0004402 | histone acetyltransferase activity |
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. | IDA |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0008607 | phosphorylase kinase regulator activity |
Modulation of the activity of the enzyme phosphorylase kinase. | IDA |
| Domain ID | Description |
|---|---|
IPR008728 | Elongator complex protein 4 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
WP2857 | Mesodermal Commitment Pathway | WikiPathways |
WP2853 | Endoderm Differentiation | WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
C0003076 | Aniridia |
C0017601 | Glaucoma |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
cerebellum | Purkinje cells |
cerebral cortex | neuronal cells |
colon | glandular cells |
duodenum | glandular cells |
endometrium | glandular cells |
gallbladder | glandular cells |
kidney | cells in glomeruli |
liver | hepatocytes |
prostate | glandular cells |
rectum | glandular cells |
small intestine | glandular cells |
smooth muscle | smooth muscle cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
SF3B3 | 23450 | Q15393 | 0.49 |
SRP68 | 6730 | Q9UHB9 | 0.63 |
ELP5 | 23587 | Q8TE02 | 0.72 |
ELP6 | 54859 | Q0PNE2 | 0.82 |
ID2 | 3398 | Q02363 | 0.63 |
PPP1CC | 5501 | P36873 | 0.63 |
SHMT2 | 6472 | P34897 | 0.63 |
CIAO1 | 9391 | O76071 | 0.63 |
HINFP | 25988 | Q9BQA5 | 0.63 |
PIPOX | 51268 | Q9P0Z9 | 0.63 |
FAM96B | 51647 | Q9Y3D0 | 0.63 |
MMS19 | 64210 | Q96T76 | 0.63 |
CBX6 | 23466 | O95503 | 0.72 |
ELP3 | 55140 | Q9H9T3 | 0.89 |
ELP2 | 55250 | Q6IA86 | 0.89 |
IKBKAP | 8518 | O95163 | 0.96 |