| Gene Symbol | ELP4 |
| Entrez ID | 26610 |
| Uniprot ID | Q96EB1 |
| Description | elongator acetyltransferase complex subunit 4 |
| Chromosomal Location | chr11: 31,509,700-31,790,328 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IDA|TAS |
|
BP |
GO:0006368 |
transcription elongation from RNA polymerase II promoter |
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
TAS |
|
BP |
GO:0043966 |
histone H3 acetylation |
The modification of histone H3 by the addition of an acetyl group. |
IDA |
|
BP |
GO:0043967 |
histone H4 acetylation |
The modification of histone H4 by the addition of an acetyl group. |
IDA |
|
BP |
GO:0045859 |
regulation of protein kinase activity |
Any process that modulates the frequency, rate or extent of protein kinase activity. |
IEA |
|
CC |
GO:0000123 |
histone acetyltransferase complex |
A protein complex that possesses histone acetyltransferase activity. |
IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
IDA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
|
CC |
GO:0008023 |
transcription elongation factor complex |
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. |
IDA |
|
CC |
GO:0033588 |
Elongator holoenzyme complex |
A heterohexameric protein complex that is involved in modification of wobble nucleosides in tRNA. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. |
IDA |
|
MF |
GO:0000993 |
RNA polymerase II core binding |
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits. |
IDA |
|
MF |
GO:0004402 |
histone acetyltransferase activity |
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0008607 |
phosphorylase kinase regulator activity |
Modulation of the activity of the enzyme phosphorylase kinase. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR008728 |
Elongator complex protein 4 |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
WP2857 |
Mesodermal Commitment Pathway |
WikiPathways |
|
WP2853 |
Endoderm Differentiation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0003076 |
Aniridia |
|
C0017601 |
Glaucoma |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in glomeruli |
|
liver |
hepatocytes |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
SF3B3 |
23450 |
Q15393 |
0.49 |
|
SRP68 |
6730 |
Q9UHB9 |
0.63 |
|
ELP5 |
23587 |
Q8TE02 |
0.72 |
|
ELP6 |
54859 |
Q0PNE2 |
0.82 |
|
ID2 |
3398 |
Q02363 |
0.63 |
|
PPP1CC |
5501 |
P36873 |
0.63 |
|
SHMT2 |
6472 |
P34897 |
0.63 |
|
CIAO1 |
9391 |
O76071 |
0.63 |
|
HINFP |
25988 |
Q9BQA5 |
0.63 |
|
PIPOX |
51268 |
Q9P0Z9 |
0.63 |
|
FAM96B |
51647 |
Q9Y3D0 |
0.63 |
|
MMS19 |
64210 |
Q96T76 |
0.63 |
|
CBX6 |
23466 |
O95503 |
0.72 |
|
ELP3 |
55140 |
Q9H9T3 |
0.89 |
|
ELP2 |
55250 |
Q6IA86 |
0.89 |
|
IKBKAP |
8518 |
O95163 |
0.96 |