Protein Description

Gene Symbol PCOLCE2
Entrez ID 26577
Uniprot ID Q9UKZ9
Description procollagen C-endopeptidase enhancer 2
Chromosomal Location chr3: 142,815,922-142,889,203
Ontology GO ID GO Term Definition Evidence

BP

GO:0010952

positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

IEA

CC

GO:0070062

extracellular exosome

A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

IDA

MF

GO:0005518

collagen binding

Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).

IDA

MF

GO:0008201

heparin binding

Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

IDA

MF

GO:0016504

peptidase activator activity

Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

IDA

Domain ID Description

IPR000859

CUB domain

IPR001134

Netrin domain

IPR008993

Tissue inhibitor of metalloproteinases-like, OB-fold

IPR018933

Netrin module, non-TIMP type

No pathways found.

UMLS CUI UMLS Term

C0236733

Amphetamine-Related Disorders

Tissue Cell Type

appendix

glandular cells

bronchus

respiratory epithelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

cells in endometrial stroma

esophagus

squamous epithelial cells

kidney

cells in glomeruli

placenta

trophoblastic cells

rectum

glandular cells

salivary gland

glandular cells

stomach

glandular cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

23824412

Piltonen et al.

2013

Mesenchymal Stem/Progenitors and Other Endometrial Cell Types From Women With Polycystic Ovary Syndrome (PCOS) Display Inflammatory and Oncogenic Potential

Gene Symbol Entrez ID Uniprot ID Score

STRN

6801

O43815

0.63

ZWINT

11130

O95229

0.63

STRN4

29888

Q9NRL3

0.63

STRN3

29966

Q13033

0.63

OLFM1

10439

Q99784

0.63

SUSD4

55061

Q5VX71

0.63