| Gene Symbol | PPP1R14B |
| Entrez ID | 26472 |
| Uniprot ID | Q96C90 |
| Description | protein phosphatase 1 regulatory inhibitor subunit 14B |
| Chromosomal Location | chr11: 64,244,480-64,246,941 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0035304 | regulation of protein dephosphorylation |
Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein. | IBA |
BP | GO:0042325 | regulation of phosphorylation |
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. | IEA |
BP | GO:0043086 | negative regulation of catalytic activity |
Any process that stops or reduces the activity of an enzyme. | IBA |
BP | GO:0045087 | innate immune response |
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. | IBA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IEA |
MF | GO:0004865 | protein serine/threonine phosphatase inhibitor activity |
Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. | IBA |
| Domain ID | Description |
|---|---|
IPR008025 | PKC-activated phosphatase-1 inhibitor |
| UMLS CUI | UMLS Term |
|---|---|
C0025202 | Melanoma |
| Tissue | Cell Type |
|---|---|
appendix | glandular cells |
bronchus | respiratory epithelial cells |
cerebellum | cells in granular layer |
cervix, uterine | squamous epithelial cells |
colon | endothelial cells |
colon | glandular cells |
endometrium | glandular cells |
epididymis | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
heart muscle | myocytes |
kidney | cells in tubules |
lung | macrophages |
lung | pneumocytes |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
pancreas | exocrine glandular cells |
parathyroid gland | glandular cells |
placenta | decidual cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
seminal vesicle | glandular cells |
skin | fibroblasts |
skin | epidermal cells |
small intestine | glandular cells |
smooth muscle | smooth muscle cells |
stomach | glandular cells |
testis | cells in seminiferous ducts |
thyroid gland | glandular cells |
urinary bladder | urothelial cells |
vagina | squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |