| Gene Symbol | HIBCH |
| Entrez ID | 26275 |
| Uniprot ID | Q6NVY1 |
| Description | 3-hydroxyisobutyryl-CoA hydrolase |
| Chromosomal Location | chr2: 190,189,735-190,344,193 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006574 |
valine catabolic process |
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid. |
IEA |
|
BP |
GO:0006635 |
fatty acid beta-oxidation |
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). |
IBA |
|
BP |
GO:0009083 |
branched-chain amino acid catabolic process |
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. |
TAS |
|
CC |
GO:0005739 |
mitochondrion |
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
IBA |
|
CC |
GO:0005759 |
mitochondrial matrix |
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
TAS |
|
CC |
GO:0070062 |
extracellular exosome |
A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
IDA |
|
MF |
GO:0003860 |
3-hydroxyisobutyryl-CoA hydrolase activity |
Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate. |
EXP|IDA |
| Domain ID | Description |
|---|---|
|
IPR029045 |
ClpP/crotonase-like domain |
|
IPR032259 |
Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00280 |
Valine, leucine and isoleucine degradation |
KEGG |
|
hsa00410 |
beta-Alanine metabolism |
KEGG |
|
hsa00640 |
Propanoate metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa01200 |
Carbon metabolism |
KEGG |
|
WP3925 |
Amino Acid metabolism |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0029408 |
Degenerative Polyarthritis |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CLIC1 |
1192 |
O00299 |
0.49 |
|
HNRNPH1 |
3187 |
P31943 |
0.49 |
|
HNRNPH2 |
3188 |
P55795 |
0.49 |
|
ALDH6A1 |
4329 |
Q02252 |
0.49 |
|
NME2 |
4831 |
P22392 |
0.49 |
|
PRCP |
5547 |
P42785 |
0.49 |
|
UMPS |
7372 |
P11172 |
0.49 |
|
ACOT9 |
23597 |
Q9Y305 |
0.49 |
|
CLIC4 |
25932 |
Q9Y696 |
0.49 |
|
UFM1 |
51569 |
P61960 |
0.49 |
|
CAB39 |
51719 |
Q9Y376 |
0.49 |
|
CLIC5 |
53405 |
Q9NZA1 |
0.49 |
|
LSM12 |
124801 |
Q3MHD2 |
0.49 |
|
ACADVL |
37 |
P49748 |
0.63 |
|
KIAA0391 |
9692 |
O15091 |
0.63 |
|
MKRN2 |
23609 |
Q9H000 |
0.63 |
|
ACADM |
34 |
P11310 |
0.49 |
|
ALDH7A1 |
501 |
P49419 |
0.49 |
|
ECI1 |
1632 |
P42126 |
0.49 |
|
FH |
2271 |
P07954 |
0.49 |
|
NEDD8 |
4738 |
Q15843 |
0.49 |
|
SOD1 |
6647 |
P00441 |
0.49 |
|
PSME3 |
10197 |
P61289 |
0.49 |
|
DSTN |
11034 |
P60981 |
0.49 |
|
PPA2 |
27068 |
Q9H2U2 |
0.49 |
|
C12orf10 |
60314 |
Q9HB07 |
0.49 |
|
IRF2BPL |
64207 |
Q9H1B7 |
0.49 |
|
ACOT1 |
641371 |
Q86TX2 |
0.49 |
|
GRB2 |
2885 |
P62993 |
0.63 |
|
SUMO2 |
6613 |
P61956 |
0.63 |
|
OXLD1 |
339229 |
Q5BKU9 |
0.63 |
|
H2AFX |
3014 |
P16104 |
0.79 |