BP

GO:0007596

blood coagulation

The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

IEA

BP

GO:0008089

anterograde axonal transport

The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.

ISS

BP

GO:0016081

synaptic vesicle docking

The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component.

NAS

BP

GO:0030318

melanocyte differentiation

The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.

IEA

BP

GO:0031175

neuron projection development

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

ISS

BP

GO:0032402

melanosome transport

The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IDA

BP

GO:0032438

melanosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.

NAS

BP

GO:0032816

positive regulation of natural killer cell activation

Any process that activates or increases the frequency, rate or extent of natural killer cell activation.

IEA

BP

GO:0033299

secretion of lysosomal enzymes

The controlled release of lysosomal enzymes by a cell.

IEA

BP

GO:0035646

endosome to melanosome transport

The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.

IDA

BP

GO:0048490

anterograde synaptic vesicle transport

The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse.

ISS

BP

GO:0050942

positive regulation of pigment cell differentiation

Any process that activates or increases the frequency, rate or extent of pigment cell differentiation.

IDA

BP

GO:0061025

membrane fusion

The membrane organization process that joins two lipid bilayers to form a single membrane.

IEA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0005768

endosome

A vacuole to which materials ingested by endocytosis are delivered.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0019898

extrinsic component of membrane

The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

IDA

CC

GO:0030133

transport vesicle

Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.

IDA

CC

GO:0031083

BLOC-1 complex

A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.

IDA

CC

GO:0031201

SNARE complex

A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.

IDA

CC

GO:0098793

presynapse

The part of a synapse that is part of the presynaptic cell.

IEA

CC

GO:1904115

axon cytoplasm

Any cytoplasm that is part of a axon.

IEA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0019905

syntaxin binding

Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.

TAS

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA|IPI

MF

GO:0051015

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

IDA