Protein Description

Gene Symbol PITPNC1
Entrez ID 26207
Uniprot ID Q9UKF7
Description phosphatidylinositol transfer protein, cytoplasmic 1
Chromosomal Location chr17: 67,377,281-67,697,261
Ontology GO ID GO Term Definition Evidence

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IMP

BP

GO:0015914

phospholipid transport

The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.

IDA

CC

GO:0005654

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0008526

phosphatidylinositol transporter activity

Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.

IDA|IMP

MF

GO:0035091

phosphatidylinositol binding

Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

IDA

MF

GO:0070300

phosphatidic acid binding

Interacting selectively and non-covalently with phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.

IDA

MF

GO:1901611

phosphatidylglycerol binding

Interacting selectively and non-covalently with phosphatidylglycerol.

IDA

Domain ID Description

IPR001666

Phosphatidylinositol transfer protein

IPR023393

START-like domain

No pathways found.

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

breast

glandular cells

bronchus

respiratory epithelial cells

caudate

glial cells

caudate

neuronal cells

cerebral cortex

neuronal cells

cerebral cortex

neuropil

cervix, uterine

glandular cells

colon

glandular cells

endometrium

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

hippocampus

neuronal cells

lung

macrophages

nasopharynx

respiratory epithelial cells

salivary gland

glandular cells

skeletal muscle

myocytes

small intestine

glandular cells

smooth muscle

smooth muscle cells

thyroid gland

glandular cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CMTM5

116173

Q96DZ9

0.63

AGTRAP

57085

Q6RW13

0.74