BP

GO:0006470

protein dephosphorylation

The process of removing one or more phosphoric residues from a protein.

IDA|TAS

BP

GO:0006914

autophagy

The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.

IEA

BP

GO:0010507

negative regulation of autophagy

Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

IMP

BP

GO:0010628

positive regulation of gene expression

Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IMP

BP

GO:0010629

negative regulation of gene expression

Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.

IMP

BP

GO:0030217

T cell differentiation

The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

ISS

BP

GO:0031663

lipopolysaccharide-mediated signaling pathway

A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.

IMP

BP

GO:0032481

positive regulation of type I interferon production

Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.

IMP

BP

GO:0032496

response to lipopolysaccharide

Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

IMP

BP

GO:0032720

negative regulation of tumor necrosis factor production

Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.

IMP

BP

GO:0032817

regulation of natural killer cell proliferation

Any process that modulates the frequency, rate or extent of natural killer cell proliferation.

IDA

BP

GO:0034141

positive regulation of toll-like receptor 3 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway.

IMP

BP

GO:0034145

positive regulation of toll-like receptor 4 signaling pathway

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.

IMP

BP

GO:0035335

peptidyl-tyrosine dephosphorylation

The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.

IEA

BP

GO:0035644

phosphoanandamide dephosphorylation

The process of removing one or more phosphate groups from a phosphorylated anandamide.

ISS

BP

GO:0043508

negative regulation of JUN kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.

IMP

BP

GO:0045088

regulation of innate immune response

Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.

IC

BP

GO:0050855

regulation of B cell receptor signaling pathway

Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.

NAS

BP

GO:0050860

negative regulation of T cell receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

IDA

BP

GO:0050868

negative regulation of T cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.

IMP

BP

GO:0070374

positive regulation of ERK1 and ERK2 cascade

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.

IMP

BP

GO:0070433

negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway

Any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.

IMP

BP

GO:0071225

cellular response to muramyl dipeptide

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.

IDA

BP

GO:1900165

negative regulation of interleukin-6 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.

IMP

BP

GO:1901222

regulation of NIK/NF-kappaB signaling

Any process that modulates the frequency, rate or extent of NIK/NF-kappaB signaling.

IMP

BP

GO:1902523

positive regulation of protein K63-linked ubiquitination

Any process that activates or increases the frequency, rate or extent of protein K63-linked ubiquitination.

IMP

BP

GO:1902715

positive regulation of interferon-gamma secretion

Any process that activates or increases the frequency, rate or extent of interferon-gamma secretion.

IMP

BP

GO:1903753

negative regulation of p38MAPK cascade

Any process that stops, prevents or reduces the frequency, rate or extent of p38MAPK cascade.

IMP

BP

GO:2000483

negative regulation of interleukin-8 secretion

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.

IMP

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IDA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA|TAS

CC

GO:0009898

cytoplasmic side of plasma membrane

The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

MF

GO:0004725

protein tyrosine phosphatase activity

Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0016791

phosphatase activity

Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.

IDA

MF

GO:0017124

SH3 domain binding

Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.

ISS

MF

GO:0019900

kinase binding

Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.

ISS

MF

GO:0031625

ubiquitin protein ligase binding

Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.

IPI