| Gene Symbol | EPC2 |
| Entrez ID | 26122 |
| Uniprot ID | Q52LR7 |
| Description | enhancer of polycomb homolog 2 (Drosophila) |
| Chromosomal Location | chr2: 148,644,440-148,787,568 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006281 |
DNA repair |
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
IEA |
|
BP |
GO:0006351 |
transcription, DNA-templated |
The cellular synthesis of RNA on a template of DNA. |
IEA |
|
BP |
GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
IBA |
|
BP |
GO:0016573 |
histone acetylation |
The modification of a histone by the addition of an acetyl group. |
IEA |
|
CC |
GO:0032777 |
Piccolo NuA4 histone acetyltransferase complex |
A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p. |
IBA |
|
MF |
GO:0004402 |
histone acetyltransferase activity |
Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. |
IBA |
| Domain ID | Description |
|---|---|
|
IPR009607 |
Enhancer of polycomb, C-terminal |
|
IPR019542 |
Enhancer of polycomb-like, N-terminal |
|
IPR024943 |
Enhancer of polycomb protein |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
cervix, uterine |
glandular cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
hippocampus |
neuronal cells |
|
lung |
macrophages |
|
nasopharynx |
respiratory epithelial cells |
|
ovary |
follicle cells |
|
pancreas |
exocrine glandular cells |
|
placenta |
trophoblastic cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
small intestine |
glandular cells |
|
spleen |
cells in red pulp |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
EZH2 |
2146 |
Q15910 |
0.49 |
|
EED |
8726 |
O75530 |
0.49 |
|
MED23 |
9439 |
Q9ULK4 |
0.49 |
|
ACTL6A |
86 |
O96019 |
0.63 |
|
MYC |
4609 |
P01106 |
0.63 |
|
VPS72 |
6944 |
Q15906 |
0.63 |
|
PLAC1 |
10761 |
Q9HBJ0 |
0.63 |
|
RUVBL2 |
10856 |
Q9Y230 |
0.63 |
|
DMAP1 |
55929 |
Q9NPF5 |
0.63 |
|
FOXR2 |
139628 |
Q6PJQ5 |
0.63 |
|
HIST1H2BA |
255626 |
Q96A08 |
0.63 |
|
HNRNPH2 |
3188 |
P55795 |
0.72 |
|
TRRAP |
8295 |
Q9Y4A5 |
0.72 |
|
MORF4L2 |
9643 |
Q15014 |
0.73 |
|
KAT5 |
10524 |
Q92993 |
0.73 |
|
MORF4L1 |
10933 |
Q9UBU8 |
0.74 |
|
YEATS4 |
8089 |
O95619 |
0.82 |
|
FOXR1 |
283150 |
Q6PIV2 |
0.82 |
|
ING3 |
54556 |
Q9NXR8 |
0.86 |
|
MRGBP |
55257 |
Q9NV56 |
0.87 |