Gene Symbol | CLCN6 |
Entrez ID | 1185 |
Uniprot ID | P51797 |
Description | chloride channel, voltage-sensitive 6 |
Chromosomal Location | chr1: 11,806,096-11,843,144 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006821 |
chloride transport |
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
NAS |
BP |
GO:0006884 |
cell volume homeostasis |
Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. |
NAS |
BP |
GO:0007165 |
signal transduction |
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
NAS |
BP |
GO:0009612 |
response to mechanical stimulus |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. |
IEA |
BP |
GO:0034220 |
ion transmembrane transport |
A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
TAS |
BP |
GO:1902476 |
chloride transmembrane transport |
The directed movement of chloride across a membrane. |
IBA |
BP |
GO:1903959 |
regulation of anion transmembrane transport |
Any process that modulates the frequency, rate or extent of anion transmembrane transport. |
IEA |
CC |
GO:0005765 |
lysosomal membrane |
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
IDA |
CC |
GO:0010008 |
endosome membrane |
The lipid bilayer surrounding an endosome. |
TAS |
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
NAS |
MF |
GO:0005247 |
voltage-gated chloride channel activity |
Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. |
IBA|NAS |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
MF |
GO:0015297 |
antiporter activity |
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). |
TAS |
MF |
GO:0031404 |
chloride ion binding |
Interacting selectively and non-covalently with chloride ions (Cl-). |
IBA |
Domain ID | Description |
---|---|
IPR000644 |
CBS domain |
IPR001807 |
Chloride channel, voltage gated |
IPR002248 |
Chloride channel ClC-6 |
IPR014743 |
Chloride channel, core |
Tissue | Cell Type |
---|---|
adrenal gland |
glandular cells |
bone marrow |
hematopoietic cells |
breast |
glandular cells |
breast |
myoepithelial cells |
bronchus |
respiratory epithelial cells |
caudate |
glial cells |
cerebellum |
cells in granular layer |
cerebellum |
Purkinje cells |
cerebral cortex |
endothelial cells |
cerebral cortex |
neuronal cells |
cerebral cortex |
neuropil |
cervix, uterine |
glandular cells |
cervix, uterine |
squamous epithelial cells |
colon |
endothelial cells |
colon |
glandular cells |
endometrium |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
hippocampus |
glial cells |
hippocampus |
neuronal cells |
kidney |
cells in tubules |
lymph node |
germinal center cells |
lymph node |
non-germinal center cells |
nasopharynx |
respiratory epithelial cells |
placenta |
decidual cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
salivary gland |
glandular cells |
seminal vesicle |
glandular cells |
skeletal muscle |
myocytes |
skin |
fibroblasts |
skin |
keratinocytes |
skin |
Langerhans |
skin |
melanocytes |
skin |
epidermal cells |
spleen |
cells in red pulp |
spleen |
cells in white pulp |
testis |
cells in seminiferous ducts |
thyroid gland |
glandular cells |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ERBB2 |
2064 |
P04626 |
0.63 |
MOV10 |
4343 |
Q9HCE1 |
0.63 |
PPP2R1A |
5518 |
P30153 |
0.63 |
LARP1 |
23367 |
Q6PKG0 |
0.63 |