Protein Description

Gene Symbol CLCN6
Entrez ID 1185
Uniprot ID P51797
Description chloride channel, voltage-sensitive 6
Chromosomal Location chr1: 11,806,096-11,843,144
Ontology GO ID GO Term Definition Evidence

BP

GO:0006821

chloride transport

The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

NAS

BP

GO:0006884

cell volume homeostasis

Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell.

NAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

NAS

BP

GO:0009612

response to mechanical stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.

IEA

BP

GO:0034220

ion transmembrane transport

A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

TAS

BP

GO:1902476

chloride transmembrane transport

The directed movement of chloride across a membrane.

IBA

BP

GO:1903959

regulation of anion transmembrane transport

Any process that modulates the frequency, rate or extent of anion transmembrane transport.

IEA

CC

GO:0005765

lysosomal membrane

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

IDA

CC

GO:0010008

endosome membrane

The lipid bilayer surrounding an endosome.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

NAS

MF

GO:0005247

voltage-gated chloride channel activity

Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

IBA|NAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0015297

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).

TAS

MF

GO:0031404

chloride ion binding

Interacting selectively and non-covalently with chloride ions (Cl-).

IBA

Domain ID Description

IPR000644

CBS domain

IPR001807

Chloride channel, voltage gated

IPR002248

Chloride channel ClC-6

IPR014743

Chloride channel, core

No pathways found.

No diseases found.

Tissue Cell Type

adrenal gland

glandular cells

bone marrow

hematopoietic cells

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

glial cells

cerebellum

cells in granular layer

cerebellum

Purkinje cells

cerebral cortex

endothelial cells

cerebral cortex

neuronal cells

cerebral cortex

neuropil

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

colon

glandular cells

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

hippocampus

glial cells

hippocampus

neuronal cells

kidney

cells in tubules

lymph node

germinal center cells

lymph node

non-germinal center cells

nasopharynx

respiratory epithelial cells

placenta

decidual cells

placenta

trophoblastic cells

prostate

glandular cells

salivary gland

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

spleen

cells in red pulp

spleen

cells in white pulp

testis

cells in seminiferous ducts

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ERBB2

2064

P04626

0.63

MOV10

4343

Q9HCE1

0.63

PPP2R1A

5518

P30153

0.63

LARP1

23367

Q6PKG0

0.63