Protein Description

Gene Symbol TENM4
Entrez ID 26011
Uniprot ID Q6N022
Description teneurin transmembrane protein 4
Chromosomal Location chr11: 78,652,831-79,440,948
Ontology GO ID GO Term Definition Evidence

BP

GO:0000902

cell morphogenesis

The developmental process in which the size or shape of a cell is generated and organized.

IBA

BP

GO:0001702

gastrulation with mouth forming second

A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.

IEA

BP

GO:0007157

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.

IBA

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

IEA

BP

GO:0031641

regulation of myelination

Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.

IMP

BP

GO:0031643

positive regulation of myelination

Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.

ISS

BP

GO:0032289

central nervous system myelin formation

The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.

IMP|ISS

BP

GO:0048666

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

IMP

BP

GO:0048714

positive regulation of oligodendrocyte differentiation

Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.

ISS

BP

GO:0060038

cardiac muscle cell proliferation

The expansion of a cardiac muscle cell population by cell division.

IEA

BP

GO:0060912

cardiac cell fate specification

The process involved in the specification of cardiac cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.

IEA

BP

GO:0097264

self proteolysis

The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.

IEA

BP

GO:2000543

positive regulation of gastrulation

Any process that activates or increases the frequency, rate or extent of gastrulation.

ISS

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

ISS

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

ISS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

IDA

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IBA

CC

GO:0043005

neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

IBA|ISS

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IBA|ISS

MF

GO:0046982

protein heterodimerization activity

Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.

IBA

MF

GO:0050839

cell adhesion molecule binding

Interacting selectively and non-covalently with a cell adhesion molecule.

IBA

Domain ID Description

IPR000742

EGF-like domain

IPR006530

YD repeat

IPR008969

Carboxypeptidase-like, regulatory domain

IPR009471

Teneurin intracellular, N-terminal

IPR011042

Six-bladed beta-propeller, TolB-like

IPR013032

EGF-like, conserved site

IPR013111

EGF-like domain, extracellular

IPR022385

Rhs repeat-associated core

IPR027691

Teneurin-4

IPR028916

Tox-GHH domain

No pathways found.

UMLS CUI UMLS Term

C0005586

Bipolar Disorder

C0028754

Obesity

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CAND1

55832

Q86VP6

0.63