PCOSBase

Protein Description

Gene Symbol	RPL36
Entrez ID	25873
Uniprot ID	Q9Y3U8
Description	ribosomal protein L36
Chromosomal Location	chr19: 5,674,947-5,691,876

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.	TAS
BP	GO:0002181	cytoplasmic translation	The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.	IBA
BP	GO:0006364	rRNA processing	Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.	TAS
BP	GO:0006412	translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome.	NAS
BP	GO:0006413	translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.	TAS
BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.	TAS
BP	GO:0019083	viral transcription	The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.	TAS
CC	GO:0005730	nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	IDA
CC	GO:0005737	cytoplasm	All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	IDA
CC	GO:0005829	cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	TAS
CC	GO:0016020	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	IDA
CC	GO:0022625	cytosolic large ribosomal subunit	The large subunit of a ribosome located in the cytosol.	IDA
MF	GO:0003735	structural constituent of ribosome	The action of a molecule that contributes to the structural integrity of the ribosome.	IBA\|NAS
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA

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Domain ID	Description
IPR000509	Ribosomal protein L36e

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Pathway ID	Pathway Term	Pathway Source
hsa03010	Ribosome	KEGG
WP477	Cytoplasmic Ribosomal Proteins	WikiPathways

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No diseases found.

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Tissue	Cell Type
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	glial cells
caudate	neuronal cells
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	glandular cells
colon	peripheral nerve/ganglion
duodenum	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
hippocampus	glial cells
hippocampus	neuronal cells
kidney	cells in tubules
liver	hepatocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
pancreas	exocrine glandular cells
placenta	decidual cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
tonsil	squamous epithelial cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
15291743	Diao et al.	2004	The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
EIF6	3692	P56537	0.49
RPSA	3921	P08865	0.49
RPL10A	4736	P62906	0.49
RPL3L	6123	Q92901	0.49
RPL12	6136	P30050	0.49
RPL27	6155	P61353	0.49
RPL28	6158	P46779	0.49
RPL37A	6168	P61513	0.49
RPLP1	6176	P05386	0.49
RPLP2	6181	P05387	0.49
RPS2	6187	P15880	0.49
RPS3A	6189	P61247	0.49
RPS5	6193	P46782	0.49
RPS7	6201	P62081	0.49
RPS9	6203	P46781	0.49
RPS11	6205	P62280	0.49
RPS14	6208	P62263	0.49
RPS15A	6210	P62244	0.49
RPS18	6222	P62269	0.49
RPS20	6224	P60866	0.49
RPS23	6228	P62266	0.49
RPS24	6229	P62847	0.49
RPS28	6234	P62857	0.49
UBA52	7311	P62987	0.49
RNPS1	10921	Q15287	0.49
RPL13A	23521	P40429	0.49
WDR12	55759	Q9GZL7	0.49
RPL9; RPL9P7; RPL9P8; RPL9P9	6133	P32969	0.49
RPS26	6231	P62854	0.56
HSD17B12	51144	Q53GQ0	0.56
RPL3	6122	P39023	0.59
RPL4	6124	P36578	0.59
RPL6	6128	Q02878	0.59
RPL7	6129	P18124	0.59
RPL38	6169	P63173	0.59
RPS4X	6191	P62701	0.59
RPS6	6194	P62753	0.59
RPS8	6202	P62241	0.59
RPS15	6209	P62841	0.59
RPS16	6217	P62249	0.59
RPS25	6230	P62851	0.59
KARS	3735	Q15046	0.63
QARS	5859	P47897	0.63
RPL17	6139	P18621	0.63
TNFRSF14	8764	Q92956	0.63
AIMP1	9255	Q12904	0.63
RPL5	6125	P46777	0.65
RPL8	6132	P62917	0.65
APP	351	P05067	0.66
RPL18A	6142	Q02543	0.73
RPLP0	6175	P05388	0.73
RPL7A	6130	P62424	0.74
DHX15	1665	O43143	0.49
NONO	4841	Q15233	0.49
PTBP1	5725	P26599	0.49
RPL22	6146	P35268	0.49
RPL24	6152	P83731	0.49
RPL31	6160	P62899	0.49
RPL35A	6165	P18077	0.49
RPS3	6188	P23396	0.49
RPS10	6204	P46783	0.49
RPS12	6206	P25398	0.49
RPS13	6207	P62277	0.49
RPS19	6223	P39019	0.49
DDX18	8886	Q9NVP1	0.49
RPL23	9349	P62829	0.49
HNRNPDL	9987	O14979	0.49
DDX42	11325	Q86XP3	0.49
GTPBP4	23560	Q9BZE4	0.49
RPL26L1	51121	Q9UNX3	0.49
C19orf43	79002	Q9BQ61	0.49
RPL10L	140801	Q96L21	0.49
GRB2	2885	P62993	0.56
RPL34	6164	P49207	0.56
RPL11	6135	P62913	0.59
RPL19	6143	P84098	0.59
RPL30	6156	P62888	0.59
RPL27A	6157	P46776	0.59
RPL14	9045	P50914	0.59
CDK2	1017	P24941	0.63
DARS	1615	P14868	0.63
ESR2	2100	Q92731	0.63
ICAM1	3383	P05362	0.63
ITGA4	3676	P13612	0.63
JUN	3725	P05412	0.63
PRKAB1	5564	Q9Y478	0.63
EIF2AK2	5610	P19525	0.63
RNF2	6045	Q99496	0.63
ABCE1	6059	P61221	0.63
TRAF6	7189	Q9Y4K3	0.63
YWHAZ	7534	P63104	0.63
UBL4A	8266	P11441	0.63
HIST1H3A	8350	P68431	0.63
CUL3	8452	Q13618	0.63
CUL2	8453	Q13617	0.63
CUL1	8454	Q13616	0.63
RTCA	8634	O00442	0.63
RIPK2	8767	O43353	0.63
ATG12	9140	O94817	0.63
EEF1E1	9521	O43324	0.63
IKBKE	9641	Q14164	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
OXSR1	9943	O95747	0.63
EIF1B	10289	O60739	0.63
GABARAP	11337	O95166	0.63
SNW1	22938	Q13573	0.63
GABARAPL1	23710	Q9H0R8	0.63
PINX1	54984	Q96BK5	0.63
CAND1	55832	Q86VP6	0.63
CDK5RAP3	80279	Q96JB5	0.63
IGSF8	93185	Q969P0	0.63
TP53RK	112858	Q96S44	0.63
RPL18	6141	Q07020	0.65
RPL35	11224	P42766	0.65
ARRB2	409	P32121	0.72
EZH2	2146	Q15910	0.72
FN1	2335	P02751	0.72
HNRNPU	3192	Q00839	0.72
NPM1	4869	P06748	0.72
NOP56	10528	O00567	0.72
MPHOSPH8	54737	Q99549	0.72
EXOSC5	56915	Q9NQT4	0.72
ESR1	2099	P03372	0.73
RPL15	6138	P61313	0.73
RPL26	6154	P61254	0.73
RPL13	6137	P26373	0.74
RPL21	6144	P46778	0.74
RPL23A	6147	P62750	0.74
MAGEB2	4113	O15479	0.76
CNBP	7555	P62633	0.76
PRKRA	8575	O75569	0.76
PSTPIP1	9051	O43586	0.76
RPL10	6134	P27635	0.82
VCAM1	7412	P19320	0.82
GABARAPL2	11345	P60520	0.82