Gene Symbol | TTLL1 |
Entrez ID | 25809 |
Uniprot ID | O95922 |
Description | tubulin tyrosine ligase like 1 |
Chromosomal Location | chr22: 43,039,644-43,089,428 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0003351 |
epithelial cilium movement |
The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid. |
IEA |
BP |
GO:0018095 |
protein polyglutamylation |
The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid. |
TAS |
BP |
GO:0035082 |
axoneme assembly |
The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements. |
IEA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IEA |
CC |
GO:0005874 |
microtubule |
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
IEA |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
MF |
GO:0070740 |
tubulin-glutamic acid ligase activity |
Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule. |
TAS |
Domain ID | Description |
---|---|
IPR004344 |
Tubulin-tyrosine ligase/Tubulin polyglutamylase |
IPR027750 |
Tubulin polyglutamylase TTLL1 |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
appendix |
lymphoid tissue |
breast |
glandular cells |
breast |
myoepithelial cells |
bronchus |
respiratory epithelial cells |
colon |
glandular cells |
duodenum |
glandular cells |
endometrium |
cells in endometrial stroma |
endometrium |
glandular cells |
epididymis |
glandular cells |
esophagus |
squamous epithelial cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
kidney |
cells in tubules |
liver |
hepatocytes |
lymph node |
germinal center cells |
nasopharynx |
respiratory epithelial cells |
ovary |
follicle cells |
pancreas |
exocrine glandular cells |
pancreas |
islets of Langerhans |
placenta |
trophoblastic cells |
prostate |
glandular cells |
rectum |
glandular cells |
small intestine |
glandular cells |
spleen |
cells in white pulp |
testis |
cells in seminiferous ducts |
testis |
Leydig cells |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
tonsil |
squamous epithelial cells |
urinary bladder |
urothelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CDC27 |
996 |
P30260 |
0.63 |
CDC23 |
8697 |
Q9UJX2 |
0.63 |
CDC16 |
8881 |
Q13042 |
0.63 |
HERC1 |
8925 |
Q15751 |
0.63 |
CCT6B |
10693 |
Q92526 |
0.63 |
DNAJB4 |
11080 |
Q9UDY4 |
0.63 |
HECTD1 |
25831 |
Q9ULT8 |
0.63 |
TPGS2 |
25941 |
Q68CL5 |
0.63 |
ANAPC2 |
29882 |
Q9UJX6 |
0.63 |
ANAPC4 |
29945 |
Q9UJX5 |
0.63 |
ANAPC5 |
51433 |
Q9UJX4 |
0.63 |
LRRC49 |
54839 |
Q8IUZ0 |
0.63 |
ANAPC1 |
64682 |
Q9H1A4 |
0.63 |
C11orf49 |
79096 |
Q9H6J7 |
0.63 |
VCPIP1 |
80124 |
Q96JH7 |
0.63 |
TPGS1 |
91978 |
Q6ZTW0 |
0.63 |
ANAPC16 |
119504 |
Q96DE5 |
0.63 |
TBC1D19 |
55296 |
Q8N5T2 |
0.70 |