Protein Description

Gene Symbol TTLL1
Entrez ID 25809
Uniprot ID O95922
Description tubulin tyrosine ligase like 1
Chromosomal Location chr22: 43,039,644-43,089,428
Ontology GO ID GO Term Definition Evidence

BP

GO:0003351

epithelial cilium movement

The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid.

IEA

BP

GO:0018095

protein polyglutamylation

The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid.

TAS

BP

GO:0035082

axoneme assembly

The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

IEA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0005874

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

IEA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0070740

tubulin-glutamic acid ligase activity

Catalysis of the posttranslational transfer of one or more glutamate residues to the gamma-carboxyl group(s) of one or more specific glutamate residues on a tubulin molecule.

TAS

Domain ID Description

IPR004344

Tubulin-tyrosine ligase/Tubulin polyglutamylase

IPR027750

Tubulin polyglutamylase TTLL1

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

appendix

lymphoid tissue

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

colon

glandular cells

duodenum

glandular cells

endometrium

cells in endometrial stroma

endometrium

glandular cells

epididymis

glandular cells

esophagus

squamous epithelial cells

fallopian tube

glandular cells

gallbladder

glandular cells

kidney

cells in tubules

liver

hepatocytes

lymph node

germinal center cells

nasopharynx

respiratory epithelial cells

ovary

follicle cells

pancreas

exocrine glandular cells

pancreas

islets of Langerhans

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

small intestine

glandular cells

spleen

cells in white pulp

testis

cells in seminiferous ducts

testis

Leydig cells

tonsil

germinal center cells

tonsil

non-germinal center cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CDC27

996

P30260

0.63

CDC23

8697

Q9UJX2

0.63

CDC16

8881

Q13042

0.63

HERC1

8925

Q15751

0.63

CCT6B

10693

Q92526

0.63

DNAJB4

11080

Q9UDY4

0.63

HECTD1

25831

Q9ULT8

0.63

TPGS2

25941

Q68CL5

0.63

ANAPC2

29882

Q9UJX6

0.63

ANAPC4

29945

Q9UJX5

0.63

ANAPC5

51433

Q9UJX4

0.63

LRRC49

54839

Q8IUZ0

0.63

ANAPC1

64682

Q9H1A4

0.63

C11orf49

79096

Q9H6J7

0.63

VCPIP1

80124

Q96JH7

0.63

TPGS1

91978

Q6ZTW0

0.63

ANAPC16

119504

Q96DE5

0.63

TBC1D19

55296

Q8N5T2

0.70