Protein Description

Gene Symbol SUN2
Entrez ID 25777
Uniprot ID Q9UH99
Description Sad1 and UNC84 domain containing 2
Chromosomal Location chr22: 38,734,725-38,794,143
Ontology GO ID GO Term Definition Evidence

BP

GO:0006998

nuclear envelope organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.

IGI

BP

GO:0007052

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

TAS

BP

GO:0007097

nuclear migration

The directed movement of the nucleus.

TAS

BP

GO:0030335

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

ISS

BP

GO:0031022

nuclear migration along microfilament

The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.

ISS

BP

GO:0051642

centrosome localization

Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.

ISS

BP

GO:0090286

cytoskeletal anchoring at nuclear membrane

The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane.

IDA

BP

GO:0090292

nuclear matrix anchoring at nuclear membrane

The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane.

IDA

CC

GO:0000784

nuclear chromosome, telomeric region

The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.

IEA

CC

GO:0000794

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.

IEA

CC

GO:0005635

nuclear envelope

The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).

IDA|TAS

CC

GO:0005639

integral component of nuclear inner membrane

The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

CC

GO:0010008

endosome membrane

The lipid bilayer surrounding an endosome.

IEA

CC

GO:0031965

nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

IDA

CC

GO:0034993

LINC complex

A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0005521

lamin binding

Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope.

IDA

MF

GO:0008017

microtubule binding

Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.

TAS

Domain ID Description

IPR008979

Galactose-binding domain-like

IPR011991

Winged helix-turn-helix DNA-binding domain

IPR012919

SUN domain

IPR030272

SUN domain-containing protein 2

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

appendix

lymphoid tissue

bone marrow

hematopoietic cells

breast

glandular cells

breast

myoepithelial cells

bronchus

respiratory epithelial cells

caudate

glial cells

caudate

neuronal cells

cerebellum

cells in granular layer

cerebellum

cells in molecular layer

cerebral cortex

endothelial cells

cerebral cortex

glial cells

cerebral cortex

neuronal cells

cervix, uterine

glandular cells

cervix, uterine

squamous epithelial cells

colon

endothelial cells

colon

glandular cells

colon

peripheral nerve/ganglion

duodenum

glandular cells

endometrium

cells in endometrial stroma

endometrium

glandular cells

epididymis

glandular cells

fallopian tube

glandular cells

gallbladder

glandular cells

heart muscle

myocytes

hippocampus

glial cells

hippocampus

neuronal cells

kidney

cells in glomeruli

kidney

cells in tubules

liver

bile duct cells

lung

macrophages

lung

pneumocytes

lymph node

germinal center cells

lymph node

non-germinal center cells

oral mucosa

squamous epithelial cells

ovary

follicle cells

ovary

ovarian stroma cells

parathyroid gland

glandular cells

placenta

trophoblastic cells

prostate

glandular cells

rectum

glandular cells

seminal vesicle

glandular cells

skeletal muscle

myocytes

skin

fibroblasts

skin

keratinocytes

skin

Langerhans

skin

melanocytes

skin

epidermal cells

small intestine

glandular cells

smooth muscle

smooth muscle cells

soft tissue

peripheral nerve

spleen

cells in red pulp

spleen

cells in white pulp

stomach

glandular cells

thyroid gland

glandular cells

tonsil

germinal center cells

tonsil

non-germinal center cells

urinary bladder

urothelial cells

vagina

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ACTC1

70

P68032

0.56

ACTN4

81

O43707

0.56

ACTN1

87

P12814

0.56

DDX3X

1654

O00571

0.56

EEF1A1

1915

P68104

0.56

EEF2

1938

P13639

0.56

EIF4A1

1973

P60842

0.56

HNRNPH1

3187

P31943

0.56

KPNB1

3837

Q14974

0.56

KPNA2

3838

P52292

0.56

MYH9

4627

P35579

0.56

MYO1C

4641

O00159

0.56

TTN

7273

Q8WZ42

0.56

UBA1

7317

P22314

0.56

COPG1

22820

Q9Y678

0.56

CORO1C

23603

Q9ULV4

0.56

LIMA1

51474

Q9UHB6

0.56

CCDC87

55231

Q9NVE4

0.56

EIF1AD

84285

Q8N9N8

0.56

COPB1

1315

P53618

0.66

LMNA

4000

P02545

0.66

SUN2

25777

Q9UH99

0.74

RAB5A

5868

P20339

0.86

E2F3

1871

O00716

0.07

TCTN3

26123

Q6NUS6

0.49

HGS

9146

O14964

0.56

IFI16

3428

Q16666

0.63

NTRK1

4914

P04629

0.63

RAB5B

5869

P61020

0.63

RPS20

6224

P60866

0.63

TP53BP1

7158

Q12888

0.63

WHSC1

7468

O96028

0.63

CFLAR

8837

O15519

0.63

ATG12

9140

O94817

0.63

NRM

11270

Q8IXM6

0.63

SCARA3

51435

Q6AZY7

0.63

TMBIM4

51643

Q9HC24

0.63

POLR1E

64425

Q9GZS1

0.63

GOLGA7B

401647

Q2TAP0

0.63

SCARNA22

677770

N/A

0.63

EMD

2010

P50402

0.68

PRKAA1

5562

Q13131

0.72

MAPK8

5599

P45983

0.72

USP20

10868

Q9Y2K6

0.72

GOLT1B

51026

Q9Y3E0

0.72

AOPEP

84909

Q8N6M6

0.72

AGO3

192669

Q9H9G7

0.72

SYNE1

23345

Q8NF91

0.79

FBXW11

23291

Q9UKB1

0.83

BTRC

8945

Q9Y297

0.84

RAB5C

5878

P51148

0.86

SYNE2

23224

Q8WXH0

0.90