Gene Symbol | SUN2 |
Entrez ID | 25777 |
Uniprot ID | Q9UH99 |
Description | Sad1 and UNC84 domain containing 2 |
Chromosomal Location | chr22: 38,734,725-38,794,143 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006998 |
nuclear envelope organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. |
IGI |
BP |
GO:0007052 |
mitotic spindle organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. |
TAS |
BP |
GO:0007097 |
nuclear migration |
The directed movement of the nucleus. |
TAS |
BP |
GO:0030335 |
positive regulation of cell migration |
Any process that activates or increases the frequency, rate or extent of cell migration. |
ISS |
BP |
GO:0031022 |
nuclear migration along microfilament |
The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins. |
ISS |
BP |
GO:0051642 |
centrosome localization |
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell. |
ISS |
BP |
GO:0090286 |
cytoskeletal anchoring at nuclear membrane |
The process in which cytoskeletal filaments are directly or indirectly linked to the nuclear membrane. |
IDA |
BP |
GO:0090292 |
nuclear matrix anchoring at nuclear membrane |
The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane. |
IDA |
CC |
GO:0000784 |
nuclear chromosome, telomeric region |
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins. |
IEA |
CC |
GO:0000794 |
condensed nuclear chromosome |
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome. |
IEA |
CC |
GO:0005635 |
nuclear envelope |
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
IDA|TAS |
CC |
GO:0005639 |
integral component of nuclear inner membrane |
The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
CC |
GO:0010008 |
endosome membrane |
The lipid bilayer surrounding an endosome. |
IEA |
CC |
GO:0031965 |
nuclear membrane |
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
IDA |
CC |
GO:0034993 |
LINC complex |
A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0005521 |
lamin binding |
Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. |
IDA |
MF |
GO:0008017 |
microtubule binding |
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. |
TAS |
Domain ID | Description |
---|---|
IPR008979 |
Galactose-binding domain-like |
IPR011991 |
Winged helix-turn-helix DNA-binding domain |
IPR012919 |
SUN domain |
IPR030272 |
SUN domain-containing protein 2 |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
appendix |
lymphoid tissue |
bone marrow |
hematopoietic cells |
breast |
glandular cells |
breast |
myoepithelial cells |
bronchus |
respiratory epithelial cells |
caudate |
glial cells |
caudate |
neuronal cells |
cerebellum |
cells in granular layer |
cerebellum |
cells in molecular layer |
cerebral cortex |
endothelial cells |
cerebral cortex |
glial cells |
cerebral cortex |
neuronal cells |
cervix, uterine |
glandular cells |
cervix, uterine |
squamous epithelial cells |
colon |
endothelial cells |
colon |
glandular cells |
colon |
peripheral nerve/ganglion |
duodenum |
glandular cells |
endometrium |
cells in endometrial stroma |
endometrium |
glandular cells |
epididymis |
glandular cells |
fallopian tube |
glandular cells |
gallbladder |
glandular cells |
heart muscle |
myocytes |
hippocampus |
glial cells |
hippocampus |
neuronal cells |
kidney |
cells in glomeruli |
kidney |
cells in tubules |
liver |
bile duct cells |
lung |
macrophages |
lung |
pneumocytes |
lymph node |
germinal center cells |
lymph node |
non-germinal center cells |
oral mucosa |
squamous epithelial cells |
ovary |
follicle cells |
ovary |
ovarian stroma cells |
parathyroid gland |
glandular cells |
placenta |
trophoblastic cells |
prostate |
glandular cells |
rectum |
glandular cells |
seminal vesicle |
glandular cells |
skeletal muscle |
myocytes |
skin |
fibroblasts |
skin |
keratinocytes |
skin |
Langerhans |
skin |
melanocytes |
skin |
epidermal cells |
small intestine |
glandular cells |
smooth muscle |
smooth muscle cells |
soft tissue |
peripheral nerve |
spleen |
cells in red pulp |
spleen |
cells in white pulp |
stomach |
glandular cells |
thyroid gland |
glandular cells |
tonsil |
germinal center cells |
tonsil |
non-germinal center cells |
urinary bladder |
urothelial cells |
vagina |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ACTC1 |
70 |
P68032 |
0.56 |
ACTN4 |
81 |
O43707 |
0.56 |
ACTN1 |
87 |
P12814 |
0.56 |
DDX3X |
1654 |
O00571 |
0.56 |
EEF1A1 |
1915 |
P68104 |
0.56 |
EEF2 |
1938 |
P13639 |
0.56 |
EIF4A1 |
1973 |
P60842 |
0.56 |
HNRNPH1 |
3187 |
P31943 |
0.56 |
KPNB1 |
3837 |
Q14974 |
0.56 |
KPNA2 |
3838 |
P52292 |
0.56 |
MYH9 |
4627 |
P35579 |
0.56 |
MYO1C |
4641 |
O00159 |
0.56 |
TTN |
7273 |
Q8WZ42 |
0.56 |
UBA1 |
7317 |
P22314 |
0.56 |
COPG1 |
22820 |
Q9Y678 |
0.56 |
CORO1C |
23603 |
Q9ULV4 |
0.56 |
LIMA1 |
51474 |
Q9UHB6 |
0.56 |
CCDC87 |
55231 |
Q9NVE4 |
0.56 |
EIF1AD |
84285 |
Q8N9N8 |
0.56 |
COPB1 |
1315 |
P53618 |
0.66 |
LMNA |
4000 |
P02545 |
0.66 |
SUN2 |
25777 |
Q9UH99 |
0.74 |
RAB5A |
5868 |
P20339 |
0.86 |
E2F3 |
1871 |
O00716 |
0.07 |
TCTN3 |
26123 |
Q6NUS6 |
0.49 |
HGS |
9146 |
O14964 |
0.56 |
IFI16 |
3428 |
Q16666 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
RAB5B |
5869 |
P61020 |
0.63 |
RPS20 |
6224 |
P60866 |
0.63 |
TP53BP1 |
7158 |
Q12888 |
0.63 |
WHSC1 |
7468 |
O96028 |
0.63 |
CFLAR |
8837 |
O15519 |
0.63 |
ATG12 |
9140 |
O94817 |
0.63 |
NRM |
11270 |
Q8IXM6 |
0.63 |
SCARA3 |
51435 |
Q6AZY7 |
0.63 |
TMBIM4 |
51643 |
Q9HC24 |
0.63 |
POLR1E |
64425 |
Q9GZS1 |
0.63 |
GOLGA7B |
401647 |
Q2TAP0 |
0.63 |
SCARNA22 |
677770 |
N/A |
0.63 |
EMD |
2010 |
P50402 |
0.68 |
PRKAA1 |
5562 |
Q13131 |
0.72 |
MAPK8 |
5599 |
P45983 |
0.72 |
USP20 |
10868 |
Q9Y2K6 |
0.72 |
GOLT1B |
51026 |
Q9Y3E0 |
0.72 |
AOPEP |
84909 |
Q8N6M6 |
0.72 |
AGO3 |
192669 |
Q9H9G7 |
0.72 |
SYNE1 |
23345 |
Q8NF91 |
0.79 |
FBXW11 |
23291 |
Q9UKB1 |
0.83 |
BTRC |
8945 |
Q9Y297 |
0.84 |
RAB5C |
5878 |
P51148 |
0.86 |
SYNE2 |
23224 |
Q8WXH0 |
0.90 |