Protein Description

Gene Symbol APOL2
Entrez ID 23780
Uniprot ID Q9BQE5
Description apolipoprotein L2
Chromosomal Location chr22: 36,226,203-36,239,954
Ontology GO ID GO Term Definition Evidence

BP

GO:0006629

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

NAS

BP

GO:0006869

lipid transport

The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

NAS

BP

GO:0006953

acute-phase response

An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

NAS

BP

GO:0007275

multicellular organism development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

NAS

BP

GO:0008203

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

NAS

BP

GO:0042157

lipoprotein metabolic process

The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.

IEA

BP

GO:0060135

maternal process involved in female pregnancy

A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.

NAS

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IEA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

NAS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

IDA

MF

GO:0005102

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

NAS

MF

GO:0008035

high-density lipoprotein particle binding

Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.

NAS

MF

GO:0008289

lipid binding

Interacting selectively and non-covalently with a lipid.

NAS

Domain ID Description

IPR008405

Apolipoprotein L

No pathways found.

UMLS CUI UMLS Term

C0024809

Marijuana Abuse

C0031391

Phencyclidine Abuse

C0036341

Schizophrenia

C0236736

Cocaine-Related Disorders

Tissue Cell Type

adrenal gland

glandular cells

bone marrow

hematopoietic cells

cerebellum

Purkinje cells

cervix, uterine

squamous epithelial cells

fallopian tube

glandular cells

hippocampus

neuronal cells

kidney

cells in glomeruli

lung

macrophages

pancreas

islets of Langerhans

placenta

decidual cells

placenta

trophoblastic cells

stomach

glandular cells

testis

Leydig cells

tonsil

squamous epithelial cells

urinary bladder

urothelial cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

UBB

7314

P0CG47

0.63

FAM127A

8933

A6ZKI3

0.63

FAM127A

8933

O15255

0.63

BSG

682

P35613

0.72

UBL4A

8266

P11441

0.72

MAST3

23031

O60307

0.72

MRPS9

64965

P82933

0.72

TCTN3

26123

Q6NUS6

0.49

TCTN2

79867

Q96GX1

0.49

ALDH3B1

221

P43353

0.63

APBB2

323

Q92870

0.63

GNAZ

2781

P19086

0.63

PSG9

5678

Q00887

0.63

STX1A

6804

Q16623

0.63

TMEM30A

55754

Q9NV96

0.63

STX1B

112755

P61266

0.63

EID3

493861

Q8N140

0.63

AR

367

P10275

0.65

NCBP1

4686

Q09161

0.72

MAPK3

5595

P27361

0.72

POLK

51426

Q9UBT6

0.72

TMEM63B

55362

Q5T3F8

0.72

CERK

64781

Q8TCT0

0.72