| Gene Symbol | APOL2 | 
| Entrez ID | 23780 | 
| Uniprot ID | Q9BQE5 | 
| Description | apolipoprotein L2 | 
| Chromosomal Location | chr22: 36,226,203-36,239,954 | 
| Ontology | GO ID | GO Term | Definition | Evidence | 
|---|---|---|---|---|
| BP | GO:0006629 | lipid metabolic process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. | NAS | 
| BP | GO:0006869 | lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. | NAS | 
| BP | GO:0006953 | acute-phase response | An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. | NAS | 
| BP | GO:0007275 | multicellular organism development | The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | NAS | 
| BP | GO:0008203 | cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. | NAS | 
| BP | GO:0042157 | lipoprotein metabolic process | The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. | IEA | 
| BP | GO:0060135 | maternal process involved in female pregnancy | A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. | NAS | 
| CC | GO:0005576 | extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. | IEA | 
| CC | GO:0005789 | endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. | NAS | 
| CC | GO:0016020 | membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IDA | 
| MF | GO:0005102 | receptor binding | Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. | NAS | 
| MF | GO:0008035 | high-density lipoprotein particle binding | Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. | NAS | 
| MF | GO:0008289 | lipid binding | Interacting selectively and non-covalently with a lipid. | NAS | 
| Domain ID | Description | 
|---|---|
| IPR008405 | Apolipoprotein L | 
| UMLS CUI | UMLS Term | 
|---|---|
| C0024809 | Marijuana Abuse | 
| C0031391 | Phencyclidine Abuse | 
| C0036341 | Schizophrenia | 
| C0236736 | Cocaine-Related Disorders | 
| Tissue | Cell Type | 
|---|---|
| adrenal gland | glandular cells | 
| bone marrow | hematopoietic cells | 
| cerebellum | Purkinje cells | 
| cervix, uterine | squamous epithelial cells | 
| fallopian tube | glandular cells | 
| hippocampus | neuronal cells | 
| kidney | cells in glomeruli | 
| lung | macrophages | 
| pancreas | islets of Langerhans | 
| placenta | decidual cells | 
| placenta | trophoblastic cells | 
| stomach | glandular cells | 
| testis | Leydig cells | 
| tonsil | squamous epithelial cells | 
| urinary bladder | urothelial cells | 
| Pubmed ID | Author | Year | Title | 
|---|---|---|---|
| 22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome | 
| Gene Symbol | Entrez ID | Uniprot ID | Score | 
|---|---|---|---|
| UBB | 7314 | P0CG47 | 0.63 | 
| FAM127A | 8933 | A6ZKI3 | 0.63 | 
| FAM127A | 8933 | O15255 | 0.63 | 
| BSG | 682 | P35613 | 0.72 | 
| UBL4A | 8266 | P11441 | 0.72 | 
| MAST3 | 23031 | O60307 | 0.72 | 
| MRPS9 | 64965 | P82933 | 0.72 | 
| TCTN3 | 26123 | Q6NUS6 | 0.49 | 
| TCTN2 | 79867 | Q96GX1 | 0.49 | 
| ALDH3B1 | 221 | P43353 | 0.63 | 
| APBB2 | 323 | Q92870 | 0.63 | 
| GNAZ | 2781 | P19086 | 0.63 | 
| PSG9 | 5678 | Q00887 | 0.63 | 
| STX1A | 6804 | Q16623 | 0.63 | 
| TMEM30A | 55754 | Q9NV96 | 0.63 | 
| STX1B | 112755 | P61266 | 0.63 | 
| EID3 | 493861 | Q8N140 | 0.63 | 
| AR | 367 | P10275 | 0.65 | 
| NCBP1 | 4686 | Q09161 | 0.72 | 
| MAPK3 | 5595 | P27361 | 0.72 | 
| POLK | 51426 | Q9UBT6 | 0.72 | 
| TMEM63B | 55362 | Q5T3F8 | 0.72 | 
| CERK | 64781 | Q8TCT0 | 0.72 |