| Gene Symbol | APOL2 |
| Entrez ID | 23780 |
| Uniprot ID | Q9BQE5 |
| Description | apolipoprotein L2 |
| Chromosomal Location | chr22: 36,226,203-36,239,954 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006629 | lipid metabolic process |
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. | NAS |
BP | GO:0006869 | lipid transport |
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. | NAS |
BP | GO:0006953 | acute-phase response |
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals. | NAS |
BP | GO:0007275 | multicellular organism development |
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). | NAS |
BP | GO:0008203 | cholesterol metabolic process |
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. | NAS |
BP | GO:0042157 | lipoprotein metabolic process |
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids. | IEA |
BP | GO:0060135 | maternal process involved in female pregnancy |
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. | NAS |
CC | GO:0005576 | extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. | IEA |
CC | GO:0005789 | endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. | NAS |
CC | GO:0016020 | membrane |
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. | IDA |
MF | GO:0005102 | receptor binding |
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. | NAS |
MF | GO:0008035 | high-density lipoprotein particle binding |
Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. | NAS |
MF | GO:0008289 | lipid binding |
Interacting selectively and non-covalently with a lipid. | NAS |
| Domain ID | Description |
|---|---|
IPR008405 | Apolipoprotein L |
| UMLS CUI | UMLS Term |
|---|---|
C0024809 | Marijuana Abuse |
C0031391 | Phencyclidine Abuse |
C0036341 | Schizophrenia |
C0236736 | Cocaine-Related Disorders |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
bone marrow | hematopoietic cells |
cerebellum | Purkinje cells |
cervix, uterine | squamous epithelial cells |
fallopian tube | glandular cells |
hippocampus | neuronal cells |
kidney | cells in glomeruli |
lung | macrophages |
pancreas | islets of Langerhans |
placenta | decidual cells |
placenta | trophoblastic cells |
stomach | glandular cells |
testis | Leydig cells |
tonsil | squamous epithelial cells |
urinary bladder | urothelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
UBB | 7314 | P0CG47 | 0.63 |
FAM127A | 8933 | A6ZKI3 | 0.63 |
FAM127A | 8933 | O15255 | 0.63 |
BSG | 682 | P35613 | 0.72 |
UBL4A | 8266 | P11441 | 0.72 |
MAST3 | 23031 | O60307 | 0.72 |
MRPS9 | 64965 | P82933 | 0.72 |
TCTN3 | 26123 | Q6NUS6 | 0.49 |
TCTN2 | 79867 | Q96GX1 | 0.49 |
ALDH3B1 | 221 | P43353 | 0.63 |
APBB2 | 323 | Q92870 | 0.63 |
GNAZ | 2781 | P19086 | 0.63 |
PSG9 | 5678 | Q00887 | 0.63 |
STX1A | 6804 | Q16623 | 0.63 |
TMEM30A | 55754 | Q9NV96 | 0.63 |
STX1B | 112755 | P61266 | 0.63 |
EID3 | 493861 | Q8N140 | 0.63 |
AR | 367 | P10275 | 0.65 |
NCBP1 | 4686 | Q09161 | 0.72 |
MAPK3 | 5595 | P27361 | 0.72 |
POLK | 51426 | Q9UBT6 | 0.72 |
TMEM63B | 55362 | Q5T3F8 | 0.72 |
CERK | 64781 | Q8TCT0 | 0.72 |