Gene Symbol | ADH7 |
Entrez ID | 131 |
Uniprot ID | P40394 |
Description | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
Chromosomal Location | chr4: 99,412,261-99,435,737 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001523 |
retinoid metabolic process |
The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. |
IDA |
BP |
GO:0006068 |
ethanol catabolic process |
The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation. |
IEA |
BP |
GO:0006069 |
ethanol oxidation |
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. |
IDA|TAS |
BP |
GO:0009617 |
response to bacterium |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. |
IDA |
BP |
GO:0010430 |
fatty acid omega-oxidation |
A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation. |
IDA |
BP |
GO:0042572 |
retinol metabolic process |
The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. |
IEA |
BP |
GO:0042573 |
retinoic acid metabolic process |
The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. |
IEA |
BP |
GO:0045471 |
response to ethanol |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
IDA |
BP |
GO:0055114 |
oxidation-reduction process |
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
IDA |
BP |
GO:1900116 |
extracellular negative regulation of signal transduction |
Any negative regulation of signal transduction that takes place in extracellular region. |
IEA |
CC |
GO:0005576 |
extracellular region |
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
MF |
GO:0004022 |
alcohol dehydrogenase (NAD) activity |
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. |
TAS |
MF |
GO:0004024 |
alcohol dehydrogenase activity, zinc-dependent |
Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. |
EXP|IDA |
MF |
GO:0004031 |
aldehyde oxidase activity |
Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide. |
IDA |
MF |
GO:0004745 |
retinol dehydrogenase activity |
Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. |
IDA |
MF |
GO:0008270 |
zinc ion binding |
Interacting selectively and non-covalently with zinc (Zn) ions. |
IEA |
MF |
GO:0019841 |
retinol binding |
Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. |
IDA |
MF |
GO:0035276 |
ethanol binding |
Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH. |
IDA |
MF |
GO:0048019 |
receptor antagonist activity |
Interacts with receptors to reduce the action of another ligand, the agonist. |
IDA |
Domain ID | Description |
---|---|
IPR002328 |
Alcohol dehydrogenase, zinc-type, conserved site |
IPR011032 |
GroES-like |
IPR013149 |
Alcohol dehydrogenase, C-terminal |
IPR013154 |
Alcohol dehydrogenase, N-terminal |
IPR016040 |
NAD(P)-binding domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa00010 |
Glycolysis / Gluconeogenesis |
KEGG |
hsa00071 |
Fatty acid degradation |
KEGG |
hsa00350 |
Tyrosine metabolism |
KEGG |
hsa00830 |
Retinol metabolism |
KEGG |
hsa00980 |
Metabolism of xenobiotics by cytochrome P450 |
KEGG |
hsa00982 |
Drug metabolism - cytochrome P450 |
KEGG |
hsa01100 |
Metabolic pathways |
KEGG |
hsa05204 |
Chemical carcinogenesis |
KEGG |
WP2884 |
NRF2 pathway |
WikiPathways |
WP3925 |
Amino Acid metabolism |
WikiPathways |
WP206 |
Fatty Acid Omega Oxidation |
WikiPathways |
UMLS CUI | UMLS Term |
---|---|
C0014859 |
Esophageal Neoplasms |
C0023055 |
Laryngeal Neoplasm |
C0026640 |
Mouth Neoplasms |
C0031347 |
Pharyngeal Neoplasms |
Tissue | Cell Type |
---|---|
bronchus |
respiratory epithelial cells |
esophagus |
squamous epithelial cells |
nasopharynx |
respiratory epithelial cells |
oral mucosa |
squamous epithelial cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
26459919 |
Lan et al. |
2015 |
Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
ADH7 |
131 |
P40394 |
0.88 |
CAND1 |
55832 |
Q86VP6 |
0.63 |