Protein Description

Gene Symbol ADH7
Entrez ID 131
Uniprot ID P40394
Description alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Chromosomal Location chr4: 99,412,261-99,435,737
Ontology GO ID GO Term Definition Evidence

BP

GO:0001523

retinoid metabolic process

The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.

IDA

BP

GO:0006068

ethanol catabolic process

The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation.

IEA

BP

GO:0006069

ethanol oxidation

An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.

IDA|TAS

BP

GO:0009617

response to bacterium

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

IDA

BP

GO:0010430

fatty acid omega-oxidation

A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation.

IDA

BP

GO:0042572

retinol metabolic process

The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.

IEA

BP

GO:0042573

retinoic acid metabolic process

The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.

IEA

BP

GO:0045471

response to ethanol

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.

IDA

BP

GO:0055114

oxidation-reduction process

A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.

IDA

BP

GO:1900116

extracellular negative regulation of signal transduction

Any negative regulation of signal transduction that takes place in extracellular region.

IEA

CC

GO:0005576

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0004022

alcohol dehydrogenase (NAD) activity

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.

TAS

MF

GO:0004024

alcohol dehydrogenase activity, zinc-dependent

Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.

EXP|IDA

MF

GO:0004031

aldehyde oxidase activity

Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.

IDA

MF

GO:0004745

retinol dehydrogenase activity

Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.

IDA

MF

GO:0008270

zinc ion binding

Interacting selectively and non-covalently with zinc (Zn) ions.

IEA

MF

GO:0019841

retinol binding

Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.

IDA

MF

GO:0035276

ethanol binding

Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH.

IDA

MF

GO:0048019

receptor antagonist activity

Interacts with receptors to reduce the action of another ligand, the agonist.

IDA

Domain ID Description

IPR002328

Alcohol dehydrogenase, zinc-type, conserved site

IPR011032

GroES-like

IPR013149

Alcohol dehydrogenase, C-terminal

IPR013154

Alcohol dehydrogenase, N-terminal

IPR016040

NAD(P)-binding domain

Pathway ID Pathway Term Pathway Source

hsa00010

Glycolysis / Gluconeogenesis

KEGG

hsa00071

Fatty acid degradation

KEGG

hsa00350

Tyrosine metabolism

KEGG

hsa00830

Retinol metabolism

KEGG

hsa00980

Metabolism of xenobiotics by cytochrome P450

KEGG

hsa00982

Drug metabolism - cytochrome P450

KEGG

hsa01100

Metabolic pathways

KEGG

hsa05204

Chemical carcinogenesis

KEGG

WP2884

NRF2 pathway

WikiPathways

WP3925

Amino Acid metabolism

WikiPathways

WP206

Fatty Acid Omega Oxidation

WikiPathways

UMLS CUI UMLS Term

C0014859

Esophageal Neoplasms

C0023055

Laryngeal Neoplasm

C0026640

Mouth Neoplasms

C0031347

Pharyngeal Neoplasms

Tissue Cell Type

bronchus

respiratory epithelial cells

esophagus

squamous epithelial cells

nasopharynx

respiratory epithelial cells

oral mucosa

squamous epithelial cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

26459919

Lan et al.

2015

Functional microarray analysis of differentially expressed genes in granulosa cells from women with polycystic ovary syndrome related to MAPK/ERK signaling

Gene Symbol Entrez ID Uniprot ID Score

ADH7

131

P40394

0.88

CAND1

55832

Q86VP6

0.63