| Gene Symbol | SGK3 |
| Entrez ID | 23678 |
| Uniprot ID | Q96BR1 |
| Description | serum/glucocorticoid regulated kinase family member 3 |
| Chromosomal Location | chr8: 66,712,418-66,862,022 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0001558 | regulation of cell growth |
Any process that modulates the frequency, rate, extent or direction of cell growth. | TAS |
BP | GO:0006468 | protein phosphorylation |
The process of introducing a phosphate group on to a protein. | TAS |
BP | GO:0006883 | cellular sodium ion homeostasis |
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. | IBA |
BP | GO:0006950 | response to stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). | TAS |
BP | GO:0010765 | positive regulation of sodium ion transport |
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. | IBA |
BP | GO:0018105 | peptidyl-serine phosphorylation |
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. | IBA |
BP | GO:0030334 | regulation of cell migration |
Any process that modulates the frequency, rate or extent of cell migration. | TAS |
BP | GO:0032411 | positive regulation of transporter activity |
Any process that activates or increases the activity of a transporter. | IBA |
BP | GO:0034220 | ion transmembrane transport |
A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. | TAS |
BP | GO:0035556 | intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. | IBA |
BP | GO:0042127 | regulation of cell proliferation |
Any process that modulates the frequency, rate or extent of cell proliferation. | TAS |
BP | GO:0042981 | regulation of apoptotic process |
Any process that modulates the occurrence or rate of cell death by apoptotic process. | IBA |
BP | GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity |
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. | TAS |
CC | GO:0005769 | early endosome |
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. | IEA |
CC | GO:0005829 | cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. | TAS |
CC | GO:0016023 | cytoplasmic, membrane-bounded vesicle |
A membrane-bounded vesicle found in the cytoplasm of the cell. | IBA |
CC | GO:0055037 | recycling endosome |
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. | IEA |
MF | GO:0004672 | protein kinase activity |
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. | TAS |
MF | GO:0004674 | protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. | IEA |
MF | GO:0005246 | calcium channel regulator activity |
Modulates the activity of a calcium channel. | TAS |
MF | GO:0005524 | ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | IEA |
MF | GO:0015459 | potassium channel regulator activity |
Modulates the activity of a potassium channel. | TAS |
MF | GO:0017080 | sodium channel regulator activity |
Modulates the activity of a sodium channel. | TAS |
MF | GO:0017081 | chloride channel regulator activity |
Modulates the activity of a chloride channel. | TAS |
MF | GO:0035091 | phosphatidylinositol binding |
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. | IEA |
| Domain ID | Description |
|---|---|
IPR000719 | Protein kinase domain |
IPR000961 | AGC-kinase, C-terminal |
IPR001683 | Phox homologous domain |
IPR008271 | Serine/threonine-protein kinase, active site |
IPR011009 | Protein kinase-like domain |
IPR017441 | Protein kinase, ATP binding site |
IPR017892 | Protein kinase, C-terminal |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
hsa04068 | FoxO signaling pathway | KEGG |
hsa04151 | PI3K-Akt signaling pathway | KEGG |
WP481 | Insulin Signaling | WikiPathways |
| Tissue | Cell Type |
|---|---|
appendix | glandular cells |
colon | glandular cells |
duodenum | glandular cells |
gallbladder | glandular cells |
pancreas | exocrine glandular cells |
placenta | decidual cells |
small intestine | glandular cells |
testis | Leydig cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
15308691 | Jansen et al. | 2004 | Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients |
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
HSP90AB1 | 3326 | P08238 | 0.49 |
SLC9A3R2 | 9351 | Q15599 | 0.52 |
APP | 351 | P05067 | 0.56 |
APLP1 | 333 | P51693 | 0.63 |
EEF1A1 | 1915 | P68104 | 0.63 |
TCF21 | 6943 | O43680 | 0.63 |
IKBKAP | 8518 | O95163 | 0.63 |
MAP4K4 | 9448 | O95819 | 0.63 |
DOPEY2 | 9980 | Q9Y3R5 | 0.63 |
NEDD4L | 23327 | Q96PU5 | 0.63 |
ERMN | 57471 | Q8TAM6 | 0.63 |
MPP5 | 64398 | Q8N3R9 | 0.63 |
ZNF621 | 285268 | Q6ZSS3 | 0.63 |
GSK3A | 2931 | P49840 | 0.66 |
ITCH | 83737 | Q96J02 | 0.79 |
GSK3B | 2932 | P49841 | 0.88 |
PDPK1 | 5170 | O15530 | 0.52 |
ESR1 | 2099 | P03372 | 0.63 |
HSP90AA1 | 3320 | P07900 | 0.63 |
PDK1 | 5163 | Q15118 | 0.7 |