Gene Symbol | SGK3 |
Entrez ID | 23678 |
Uniprot ID | Q96BR1 |
Description | serum/glucocorticoid regulated kinase family member 3 |
Chromosomal Location | chr8: 66,712,418-66,862,022 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0001558 |
regulation of cell growth |
Any process that modulates the frequency, rate, extent or direction of cell growth. |
TAS |
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
TAS |
BP |
GO:0006883 |
cellular sodium ion homeostasis |
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell. |
IBA |
BP |
GO:0006950 |
response to stress |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). |
TAS |
BP |
GO:0010765 |
positive regulation of sodium ion transport |
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
IBA |
BP |
GO:0018105 |
peptidyl-serine phosphorylation |
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
IBA |
BP |
GO:0030334 |
regulation of cell migration |
Any process that modulates the frequency, rate or extent of cell migration. |
TAS |
BP |
GO:0032411 |
positive regulation of transporter activity |
Any process that activates or increases the activity of a transporter. |
IBA |
BP |
GO:0034220 |
ion transmembrane transport |
A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
TAS |
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IBA |
BP |
GO:0042127 |
regulation of cell proliferation |
Any process that modulates the frequency, rate or extent of cell proliferation. |
TAS |
BP |
GO:0042981 |
regulation of apoptotic process |
Any process that modulates the occurrence or rate of cell death by apoptotic process. |
IBA |
BP |
GO:0051090 |
regulation of sequence-specific DNA binding transcription factor activity |
Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
TAS |
CC |
GO:0005769 |
early endosome |
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
IEA |
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
CC |
GO:0016023 |
cytoplasmic, membrane-bounded vesicle |
A membrane-bounded vesicle found in the cytoplasm of the cell. |
IBA |
CC |
GO:0055037 |
recycling endosome |
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
IEA |
MF |
GO:0004672 |
protein kinase activity |
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
TAS |
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IEA |
MF |
GO:0005246 |
calcium channel regulator activity |
Modulates the activity of a calcium channel. |
TAS |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
MF |
GO:0015459 |
potassium channel regulator activity |
Modulates the activity of a potassium channel. |
TAS |
MF |
GO:0017080 |
sodium channel regulator activity |
Modulates the activity of a sodium channel. |
TAS |
MF |
GO:0017081 |
chloride channel regulator activity |
Modulates the activity of a chloride channel. |
TAS |
MF |
GO:0035091 |
phosphatidylinositol binding |
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
IEA |
Domain ID | Description |
---|---|
IPR000719 |
Protein kinase domain |
IPR000961 |
AGC-kinase, C-terminal |
IPR001683 |
Phox homologous domain |
IPR008271 |
Serine/threonine-protein kinase, active site |
IPR011009 |
Protein kinase-like domain |
IPR017441 |
Protein kinase, ATP binding site |
IPR017892 |
Protein kinase, C-terminal |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04068 |
FoxO signaling pathway |
KEGG |
hsa04151 |
PI3K-Akt signaling pathway |
KEGG |
WP481 |
Insulin Signaling |
WikiPathways |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
colon |
glandular cells |
duodenum |
glandular cells |
gallbladder |
glandular cells |
pancreas |
exocrine glandular cells |
placenta |
decidual cells |
small intestine |
glandular cells |
testis |
Leydig cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
15308691 |
Jansen et al. |
2004 |
Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients |
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
HSP90AB1 |
3326 |
P08238 |
0.49 |
SLC9A3R2 |
9351 |
Q15599 |
0.52 |
APP |
351 |
P05067 |
0.56 |
APLP1 |
333 |
P51693 |
0.63 |
EEF1A1 |
1915 |
P68104 |
0.63 |
TCF21 |
6943 |
O43680 |
0.63 |
IKBKAP |
8518 |
O95163 |
0.63 |
MAP4K4 |
9448 |
O95819 |
0.63 |
DOPEY2 |
9980 |
Q9Y3R5 |
0.63 |
NEDD4L |
23327 |
Q96PU5 |
0.63 |
ERMN |
57471 |
Q8TAM6 |
0.63 |
MPP5 |
64398 |
Q8N3R9 |
0.63 |
ZNF621 |
285268 |
Q6ZSS3 |
0.63 |
GSK3A |
2931 |
P49840 |
0.66 |
ITCH |
83737 |
Q96J02 |
0.79 |
GSK3B |
2932 |
P49841 |
0.88 |
PDPK1 |
5170 |
O15530 |
0.52 |
ESR1 |
2099 |
P03372 |
0.63 |
HSP90AA1 |
3320 |
P07900 |
0.63 |
PDK1 |
5163 |
Q15118 |
0.70 |