Protein Description

Gene Symbol SGK3
Entrez ID 23678
Uniprot ID Q96BR1
Description serum/glucocorticoid regulated kinase family member 3
Chromosomal Location chr8: 66,712,418-66,862,022
Ontology GO ID GO Term Definition Evidence

BP

GO:0001558

regulation of cell growth

Any process that modulates the frequency, rate, extent or direction of cell growth.

TAS

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

TAS

BP

GO:0006883

cellular sodium ion homeostasis

Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.

IBA

BP

GO:0006950

response to stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

TAS

BP

GO:0010765

positive regulation of sodium ion transport

Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IBA

BP

GO:0018105

peptidyl-serine phosphorylation

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

IBA

BP

GO:0030334

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

TAS

BP

GO:0032411

positive regulation of transporter activity

Any process that activates or increases the activity of a transporter.

IBA

BP

GO:0034220

ion transmembrane transport

A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.

TAS

BP

GO:0035556

intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

IBA

BP

GO:0042127

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

TAS

BP

GO:0042981

regulation of apoptotic process

Any process that modulates the occurrence or rate of cell death by apoptotic process.

IBA

BP

GO:0051090

regulation of sequence-specific DNA binding transcription factor activity

Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.

TAS

CC

GO:0005769

early endosome

A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

CC

GO:0016023

cytoplasmic, membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

IBA

CC

GO:0055037

recycling endosome

An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

IEA

MF

GO:0004672

protein kinase activity

Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

TAS

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

IEA

MF

GO:0005246

calcium channel regulator activity

Modulates the activity of a calcium channel.

TAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0015459

potassium channel regulator activity

Modulates the activity of a potassium channel.

TAS

MF

GO:0017080

sodium channel regulator activity

Modulates the activity of a sodium channel.

TAS

MF

GO:0017081

chloride channel regulator activity

Modulates the activity of a chloride channel.

TAS

MF

GO:0035091

phosphatidylinositol binding

Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

IEA

Domain ID Description

IPR000719

Protein kinase domain

IPR000961

AGC-kinase, C-terminal

IPR001683

Phox homologous domain

IPR008271

Serine/threonine-protein kinase, active site

IPR011009

Protein kinase-like domain

IPR017441

Protein kinase, ATP binding site

IPR017892

Protein kinase, C-terminal

Pathway ID Pathway Term Pathway Source

hsa04068

FoxO signaling pathway

KEGG

hsa04151

PI3K-Akt signaling pathway

KEGG

WP481

Insulin Signaling

WikiPathways

No diseases found.

Tissue Cell Type

appendix

glandular cells

colon

glandular cells

duodenum

glandular cells

gallbladder

glandular cells

pancreas

exocrine glandular cells

placenta

decidual cells

small intestine

glandular cells

testis

Leydig cells

No databases found.

Pubmed ID Author Year Title

15308691

Jansen et al.

2004

Abnormal Gene Expression Profiles in Human Ovaries from Polycystic Ovary Syndrome Patients

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

HSP90AB1

3326

P08238

0.49

SLC9A3R2

9351

Q15599

0.52

APP

351

P05067

0.56

APLP1

333

P51693

0.63

EEF1A1

1915

P68104

0.63

TCF21

6943

O43680

0.63

IKBKAP

8518

O95163

0.63

MAP4K4

9448

O95819

0.63

DOPEY2

9980

Q9Y3R5

0.63

NEDD4L

23327

Q96PU5

0.63

ERMN

57471

Q8TAM6

0.63

MPP5

64398

Q8N3R9

0.63

ZNF621

285268

Q6ZSS3

0.63

GSK3A

2931

P49840

0.66

ITCH

83737

Q96J02

0.79

GSK3B

2932

P49841

0.88

PDPK1

5170

O15530

0.52

ESR1

2099

P03372

0.63

HSP90AA1

3320

P07900

0.63

PDK1

5163

Q15118

0.70