BP

GO:0001755

neural crest cell migration

The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.

IMP

BP

GO:0001932

regulation of protein phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

IGI

BP

GO:0001933

negative regulation of protein phosphorylation

Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.

IMP

BP

GO:0006909

phagocytosis

An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.

TAS

BP

GO:0007165

signal transduction

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

TAS

BP

GO:0010632

regulation of epithelial cell migration

Any process that modulates the frequency, rate or extent of epithelial cell migration.

IGI

BP

GO:0010633

negative regulation of epithelial cell migration

Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.

IMP

BP

GO:0010762

regulation of fibroblast migration

Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.

ISS

BP

GO:0030036

actin cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

IBA

BP

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.

IMP

BP

GO:0045184

establishment of protein localization

The directed movement of a protein to a specific location.

ISS

BP

GO:0051893

regulation of focal adhesion assembly

Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.

IGI

BP

GO:0051895

negative regulation of focal adhesion assembly

Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.

IMP

BP

GO:0090630

activation of GTPase activity

Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.

ISS

BP

GO:1900024

regulation of substrate adhesion-dependent cell spreading

Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading.

IGI

BP

GO:1900025

negative regulation of substrate adhesion-dependent cell spreading

Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.

IMP

BP

GO:1900027

regulation of ruffle assembly

Any process that modulates the frequency, rate or extent of ruffle assembly.

IEA

BP

GO:2000394

positive regulation of lamellipodium morphogenesis

Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.

IMP

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IEA

CC

GO:0005925

focal adhesion

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

IDA

CC

GO:0015629

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

IDA

CC

GO:0016328

lateral plasma membrane

The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.

IDA

CC

GO:0016600

flotillin complex

A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.

ISS

CC

GO:0030027

lamellipodium

A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.

IDA

CC

GO:0031982

vesicle

Any small, fluid-filled, spherical organelle enclosed by membrane.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0048365

Rac GTPase binding

Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.

IEA

MF

GO:0051015

actin filament binding

Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

IMP