Protein Description

Gene Symbol TSPAN12
Entrez ID 23554
Uniprot ID O95859
Description tetraspanin 12
Chromosomal Location chr7: 120,787,320-120,858,402
Ontology GO ID GO Term Definition Evidence

BP

GO:0001525

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

IEA

BP

GO:0007166

cell surface receptor signaling pathway

A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.

IBA|ISS

BP

GO:0010842

retina layer formation

The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.

ISS

BP

GO:0045765

regulation of angiogenesis

Any process that modulates the frequency, rate or extent of angiogenesis.

ISS

CC

GO:0005887

integral component of plasma membrane

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IBA|ISS

CC

GO:0016020

membrane

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

TAS

Domain ID Description

IPR000301

Tetraspanin

IPR008952

Tetraspanin, EC2 domain

IPR018499

Tetraspanin/Peripherin

IPR018503

Tetraspanin, conserved site

No pathways found.

No diseases found.

Tissue Cell Type

lung

macrophages

placenta

decidual cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

FZD4

8322

Q9ULV1

0.52

NDP

4693

Q00604

0.63

TFCP2

7024

Q12800

0.63