PCOSBase

Protein Description

Gene Symbol	SRRM2
Entrez ID	23524
Uniprot ID	Q9UQ35
Description	serine/arginine repetitive matrix 2
Chromosomal Location	chr16: 2,752,329-2,772,538

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Ontology	GO ID	GO Term	Definition	Evidence
BP	GO:0000398	mRNA splicing, via spliceosome	The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.	IC
CC	GO:0005654	nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.	IDA
CC	GO:0015030	Cajal body	A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.	IDA
CC	GO:0016607	nuclear speck	A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.	IDA
CC	GO:0071013	catalytic step 2 spliceosome	A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.	IDA
MF	GO:0044822	poly(A) RNA binding	Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.	IDA
MF	GO:0047485	protein N-terminus binding	Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.	IPI
MF	GO:0070742	C2H2 zinc finger domain binding	Interacting selectively and non-covalently with a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.	IDA

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Domain ID	Description
IPR013170	mRNA splicing factor Cwf21 domain
IPR024945	Spt5 C-terminal domain

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No pathways found.

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No diseases found.

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Tissue	Cell Type
adrenal gland	glandular cells
appendix	glandular cells
appendix	lymphoid tissue
bone marrow	hematopoietic cells
breast	glandular cells
breast	myoepithelial cells
bronchus	respiratory epithelial cells
caudate	neuronal cells
cerebellum	cells in granular layer
cerebellum	cells in molecular layer
cerebellum	Purkinje cells
cerebral cortex	glial cells
cerebral cortex	neuronal cells
cervix, uterine	glandular cells
cervix, uterine	squamous epithelial cells
colon	endothelial cells
duodenum	glandular cells
endometrium	cells in endometrial stroma
endometrium	glandular cells
epididymis	glandular cells
esophagus	squamous epithelial cells
fallopian tube	glandular cells
gallbladder	glandular cells
heart muscle	myocytes
kidney	cells in glomeruli
kidney	cells in tubules
liver	bile duct cells
liver	hepatocytes
lung	macrophages
lung	pneumocytes
lymph node	germinal center cells
lymph node	non-germinal center cells
nasopharynx	respiratory epithelial cells
oral mucosa	squamous epithelial cells
ovary	follicle cells
ovary	ovarian stroma cells
pancreas	exocrine glandular cells
pancreas	islets of Langerhans
parathyroid gland	glandular cells
placenta	trophoblastic cells
prostate	glandular cells
rectum	glandular cells
salivary gland	glandular cells
seminal vesicle	glandular cells
skeletal muscle	myocytes
skin	fibroblasts
skin	keratinocytes
skin	Langerhans
skin	melanocytes
skin	epidermal cells
small intestine	glandular cells
smooth muscle	smooth muscle cells
soft tissue	fibroblasts
spleen	cells in red pulp
spleen	cells in white pulp
stomach	glandular cells
testis	cells in seminiferous ducts
testis	Leydig cells
thyroid gland	glandular cells
tonsil	germinal center cells
tonsil	non-germinal center cells
urinary bladder	urothelial cells
vagina	squamous epithelial cells

No databases found.

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Pubmed ID	Author	Year	Title
15291743	Diao et al.	2004	The molecular characteristics of polycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray
22951915	Haozi et al.	2012	Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

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Gene Symbol	Entrez ID	Uniprot ID	Score
RPL6	6128	Q02878	0.49
U2AF1	7307	Q01081	0.49
ALYREF	10189	Q86V81	0.49
PRPF8	10594	Q6P2Q9	0.49
STAG2	10735	Q8N3U4	0.49
UTP14A	10813	Q9BVJ6	0.49
THOC6	79228	Q86W42	0.49
CDC73	79577	Q6P1J9	0.49
PYM1	84305	Q9BRP8	0.49
APP	351	P05067	0.56
ACO2	50	Q99798	0.63
SEPT7	989	Q16181	0.63
DBT	1629	P11182	0.63
DDX1	1653	Q92499	0.63
DDX3X	1654	O00571	0.63
DHPS	1725	P49366	0.63
DYNC1I2	1781	Q13409	0.63
EEF1A2	1917	Q05639	0.63
EEF1B2	1933	P24534	0.63
EEF1D	1936	P29692	0.63
EIF4A1	1973	P60842	0.63
ELAVL1	1994	Q15717	0.63
XRCC6	2547	P12956	0.63
GTF2I	2969	P78347	0.63
HNRNPA2B1	3181	P22626	0.63
HNRNPC	3183	P07910	0.63
HNRNPF	3185	P52597	0.63
HNRNPH3	3189	P31942	0.63
HNRNPL	3191	P14866	0.63
DNAJA1	3301	P31689	0.63
HSPB1	3315	P04792	0.63
HSPD1	3329	P10809	0.63
LMNA	4000	P02545	0.63
MCM6	4175	Q14566	0.63
MEP1A	4224	Q16819	0.63
MYL6	4637	P60660	0.63
NONO	4841	Q15233	0.63
YBX1	4904	P67809	0.63
PDHB	5162	P11177	0.63
PLEC	5339	Q15149	0.63
PPP4C	5531	P60510	0.63
PRNP	5621	P04156	0.63
PSMC1	5700	P62191	0.63
PSMC4	5704	P43686	0.63
PSMC5	5705	P62195	0.63
RBBP4	5928	Q09028	0.63
RPL7A	6130	P62424	0.63
MRPL12	6182	P52815	0.63
RPS2	6187	P15880	0.63
RPS3A	6189	P61247	0.63
RPS5	6193	P46782	0.63
RPS7	6201	P62081	0.63
RPS19	6223	P39019	0.63
SFPQ	6421	P23246	0.63
SRSF4	6429	Q08170	0.63
SMARCC1	6599	Q92922	0.63
SNRPD1	6632	P62314	0.63
SNRPD2	6633	P62316	0.63
SNRPD3	6634	P62318	0.63
SNRPF	6636	P62306	0.63
SPTBN1	6711	Q01082	0.63
TUBA4A	7277	P68366	0.63
VCP	7415	P55072	0.63
VIM	7431	P08670	0.63
TRIM26	7726	Q12899	0.63
CDK2AP1	8099	O14519	0.63
DHX16	8449	O60231	0.63
EIF3B	8662	P55884	0.63
EIF3F	8665	O00303	0.63
EIF3H	8667	O15372	0.63
EIF3I	8668	Q13347	0.63
SQSTM1	8878	Q13501	0.63
DDX21	9188	Q9NR30	0.63
MTA2	9219	O94776	0.63
EFTUD2	9343	Q15029	0.63
TJP2	9414	Q9UDY2	0.63
BAG2	9532	O95816	0.63
RBM7	10179	Q9Y580	0.63
BCAS2	10286	O75934	0.63
SLU7	10569	O95391	0.63
SEPT9	10801	Q9UHD8	0.63
RUVBL2	10856	Q9Y230	0.63
SF3B2	10992	Q13435	0.63
DNAJC8	22826	O75937	0.63
CCT5	22948	P48643	0.63
SEPT8	23176	Q92599	0.63
PRPF19	27339	Q9UMS4	0.63
PPIL1	51645	Q9Y3C6	0.63
MRPS23	51649	Q9Y3D9	0.63
CDK12	51755	Q9NYV4	0.63
CECR1	51816	Q9NZK5	0.63
MBD3	53615	O95983	0.63
ABCF3	55324	Q9NUQ8	0.63
RAD18	56852	Q9NS91	0.63
MRPS6	64968	P82932	0.63
DDX50	79009	Q9BQ39	0.63
FIP1L1	81608	Q6UN15	0.63
SF3B5	83443	Q9BWJ5	0.63
EPPK1	83481	P58107	0.63
GTF3C6	112495	Q969F1	0.63
CALR3	125972	Q96L12	0.63
TTC14	151613	Q96N46	0.63
PPP4R2	151987	Q9NY27	0.63
CDC5L	988	Q99459	0.73
DDX5	1655	P17844	0.73
EEF1A1	1915	P68104	0.73
HNRNPA1	3178	P09651	0.73
HNRNPH1	3187	P31943	0.73
HSPA1A	3303	P0DMV8	0.73
HSPA1B	3304	P0DMV9	0.73
HNRNPM	4670	P52272	0.73
SEPT2	4735	Q15019	0.73
RPS13	6207	P62277	0.73
SNRPA1	6627	P09661	0.73
SNRPC	6631	P09234	0.73
YWHAE	7531	P62258	0.73
RBM39	9584	Q14498	0.73
RBM8A	9939	Q9Y5S9	0.73
SF3B4	10262	Q15427	0.73
SF3B3	23450	Q15393	0.73
PRPF6	24148	O94906	0.73
RBMX	27316	P38159	0.73
PRPF40A	55660	O75400	0.73
SNIP1	79753	Q8TAD8	0.82
EIF4A3	9775	P38919	0.83
PNN	5411	Q9H307	0.86
CSNK2A1	1457	P68400	0.87
YWHAG	7532	P61981	0.88
DHX9	1660	Q08211	0.49
DHX15	1665	O43143	0.49
FBL	2091	P22087	0.49
FLNA	2316	P21333	0.49
HNRNPK	3190	P61978	0.49
HNRNPU	3192	Q00839	0.49
HSPA5	3309	P11021	0.49
ILF2	3608	Q12905	0.49
ILF3	3609	Q12906	0.49
NDUFA7	4701	O95182	0.49
SCP2	6342	P22307	0.49
SRSF1	6426	Q07955	0.49
SNRPB2	6629	P08579	0.49
SON	6651	P18583	0.49
SRP14	6727	P37108	0.49
BAZ1B	9031	Q9UIG0	0.49
SART1	9092	O43290	0.49
PRPF3	9129	O43395	0.49
SRSF11	9295	Q05519	0.49
SF3A1	10291	Q15459	0.49
SYNCRIP	10492	O60506	0.49
SUB1	10923	P53999	0.49
PUF60	22827	Q9UHX1	0.49
ACIN1	22985	Q9UKV3	0.49
SNRNP200	23020	O75643	0.49
RTF1	23168	Q92541	0.49
SF3B1	23451	O75533	0.49
PRPF40B	25766	Q6NWY9	0.49
SBDS	51119	Q9Y3A5	0.49
SARNP	84324	P82979	0.49
ZC3H18	124245	Q86VM9	0.49
HNRNPA3	220988	P51991	0.49
CLK1	1195	P49759	0.52
SUMO1	7341	P63165	0.56
SRSF5	6430	Q13243	0.59
RBM25	58517	P49756	0.59
AIRE	326	O43918	0.63
BARD1	580	Q99728	0.63
CDK2	1017	P24941	0.63
CDK5	1020	Q00535	0.63
CSNK2A2	1459	P19784	0.63
EDA	1896	Q92838	0.63
ESR1	2099	P03372	0.63
GRK5	2869	P34947	0.63
IFI16	3428	Q16666	0.63
JAK3	3718	P52333	0.63
MAGEB2	4113	O15479	0.63
MDM2	4193	Q00987	0.63
NTRK1	4914	P04629	0.63
ABCE1	6059	P61221	0.63
RPL31	6160	P62899	0.63
TADA2A	6871	O75478	0.63
TERF2	7014	Q15554	0.63
SF1	7536	Q15637	0.63
SF3A2	8175	Q15428	0.63
HIST1H3A	8350	P68431	0.63
CUL3	8452	Q13618	0.63
EED	8726	O75530	0.63
KIAA0101	9768	Q15004	0.63
CUL7	9820	Q14999	0.63
PAN2	9924	Q504Q3	0.63
ZMYND11	10771	Q15326	0.63
COPS5	10987	Q92905	0.63
GABARAP	11337	O95166	0.63
SNW1	22938	Q13573	0.63
PAXIP1	22976	Q6ZW49	0.63
OBSL1	23363	O75147	0.63
TRA2A	29896	Q13595	0.63
SH3KBP1	30011	Q96B97	0.63
DDX41	51428	Q9UJV9	0.63
SIRT7	51547	Q9NRC8	0.63
XRN1	54464	Q8IZH2	0.63
C11orf57	55216	Q6ZUT1	0.63
LUC7L	55692	Q9NQ29	0.63
CAND1	55832	Q86VP6	0.63
WDR76	79968	Q9H967	0.63
SLC25A32	81034	Q9H2D1	0.63
MAP1LC3B	81631	Q9GZQ8	0.63
MAP1LC3A	84557	Q9H492	0.63
UNK	85451	Q9C0B0	0.63
PYHIN1	149628	Q6K0P9	0.63
FAM9A	171482	Q8IZU1	0.63
PIN1	5300	Q13526	0.68
YWHAZ	7534	P63104	0.68
ARRB1	408	P49407	0.72
ARRB2	409	P32121	0.72
CLK3	1198	P49761	0.72
HDAC2	3066	Q92769	0.72
ILK	3611	Q13418	0.72
MAGOH	4116	P61326	0.72
PFKFB2	5208	O60825	0.72
YWHAH	7533	Q04917	0.72
PRPF4B	8899	Q13523	0.72
NUAK1	9891	O60285	0.72
HDAC6	10013	Q9UBN7	0.72
EPB41L3	23136	Q9Y2J2	0.72
HINFP	25988	Q9BQA5	0.72
SRPK3	26576	Q9UPE1	0.72
CLK4	57396	Q9HAZ1	0.72
HDAC11	79885	Q96DB2	0.72
RASSF10	644943	A6NK89	0.72
SUMO2	6613	P61956	0.74
BAK1	578	Q16611	0.76
SFN	2810	P31947	0.76
USP42	84132	Q9H9J4	0.76
OSBPL10	114884	Q9BXB5	0.76
ESR2	2100	Q92731	0.77
SRPK2	6733	P78362	0.83
SRRM1	10250	Q8IYB3	0.84
SRPK1	6732	Q96SB4	0.86
RNPS1	10921	Q15287	0.86
YWHAB	7529	P31946	0.88