| Gene Symbol | SKIV2L2 |
| Entrez ID | 23517 |
| Uniprot ID | P42285 |
| Description | superkiller viralicidic activity 2-like 2 (S. cerevisiae) |
| Chromosomal Location | chr5: 55,307,760-55,425,581 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0000398 |
mRNA splicing, via spliceosome |
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
IC |
|
BP |
GO:0000460 |
maturation of 5.8S rRNA |
Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule. |
IMP |
|
BP |
GO:0006364 |
rRNA processing |
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
TAS |
|
BP |
GO:0006401 |
RNA catabolic process |
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
IEA |
|
CC |
GO:0000178 |
exosome (RNase complex) |
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. |
IDA |
|
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IDA |
|
CC |
GO:0005654 |
nucleoplasm |
That part of the nuclear content other than the chromosomes or the nucleolus. |
TAS |
|
CC |
GO:0005730 |
nucleolus |
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
IEA |
|
CC |
GO:0071013 |
catalytic step 2 spliceosome |
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
IDA |
|
MF |
GO:0003724 |
RNA helicase activity |
Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix. |
IEA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
|
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR001650 |
Helicase, C-terminal |
|
IPR011545 |
DEAD/DEAH box helicase domain |
|
IPR012961 |
ATP-dependent RNA helicase Ski2, C-terminal |
|
IPR014001 |
Helicase superfamily 1/2, ATP-binding domain |
|
IPR016438 |
ATP-dependent RNA helicase Ski2 |
|
IPR025696 |
rRNA-processing arch domain |
|
IPR027417 |
P-loop containing nucleoside triphosphate hydrolase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa03018 |
RNA degradation |
KEGG |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
bronchus |
respiratory epithelial cells |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
kidney |
cells in tubules |
|
liver |
hepatocytes |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
thyroid gland |
glandular cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CSE1L |
1434 |
P55060 |
0.49 |
|
DDX5 |
1655 |
P17844 |
0.49 |
|
EIF4G1 |
1981 |
Q04637 |
0.49 |
|
LIG1 |
3978 |
P18858 |
0.49 |
|
NOP2 |
4839 |
P46087 |
0.49 |
|
SNRPD2 |
6633 |
P62316 |
0.49 |
|
EIF3H |
8667 |
O15372 |
0.49 |
|
EIF4A3 |
9775 |
P38919 |
0.49 |
|
DHX38 |
9785 |
Q92620 |
0.49 |
|
PUM3 |
9933 |
Q15397 |
0.49 |
|
KIF2C |
11004 |
Q99661 |
0.49 |
|
SNW1 |
22938 |
Q13573 |
0.49 |
|
RRP12 |
23223 |
Q5JTH9 |
0.49 |
|
TRMT6 |
51605 |
Q9UJA5 |
0.49 |
|
NLE1 |
54475 |
Q9NVX2 |
0.49 |
|
ANKMY2 |
57037 |
Q8IV38 |
0.49 |
|
EFL1 |
79631 |
Q7Z2Z2 |
0.49 |
|
SP1 |
6667 |
P08047 |
0.52 |
|
PABPC4 |
8761 |
Q13310 |
0.56 |
|
RRS1 |
23212 |
Q15050 |
0.56 |
|
PABPC1 |
26986 |
P11940 |
0.56 |
|
EXOSC9 |
5393 |
Q06265 |
0.59 |
|
EXOSC10 |
5394 |
Q01780 |
0.62 |
|
PBX2 |
5089 |
P40425 |
0.63 |
|
UPF2 |
26019 |
Q9HAU5 |
0.63 |
|
XRN1 |
54464 |
Q8IZH2 |
0.63 |
|
EXOSC2 |
23404 |
Q13868 |
0.65 |
|
EXOSC8 |
11340 |
Q96B26 |
0.75 |
|
DIS3 |
22894 |
Q9Y2L1 |
0.75 |
|
EXOSC7 |
23016 |
Q15024 |
0.75 |
|
MPP6 |
51678 |
Q9NZW5 |
0.75 |
|
EXOSC4 |
54512 |
Q9NPD3 |
0.75 |
|
EXOSC6 |
118460 |
Q5RKV6 |
0.75 |
|
EXOSC5 |
56915 |
Q9NQT4 |
0.89 |
|
CAPN1 |
823 |
P07384 |
0.49 |
|
CTPS1 |
1503 |
P17812 |
0.49 |
|
YBX1 |
4904 |
P67809 |
0.49 |
|
SKP2 |
6502 |
Q13309 |
0.49 |
|
YBX3 |
8531 |
P16989 |
0.49 |
|
CWC27 |
10283 |
Q6UX04 |
0.49 |
|
SF3A1 |
10291 |
Q15459 |
0.49 |
|
NUDT21 |
11051 |
O43809 |
0.49 |
|
CAPN11 |
11131 |
Q9UMQ6 |
0.49 |
|
DBR1 |
51163 |
Q9UK59 |
0.49 |
|
METTL13 |
51603 |
Q8N6R0 |
0.49 |
|
DOHH |
83475 |
Q9BU89 |
0.49 |
|
TRMT61A |
115708 |
Q96FX7 |
0.49 |
|
DHX15 |
1665 |
O43143 |
0.56 |
|
SUMO1 |
7341 |
P63165 |
0.56 |
|
TTC27 |
55622 |
Q6P3X3 |
0.56 |
|
BMI1 |
648 |
P35226 |
0.63 |
|
CDC5L |
988 |
Q99459 |
0.63 |
|
GRK5 |
2869 |
P34947 |
0.63 |
|
IGHA1 |
3493 |
P01876 |
0.63 |
|
JUN |
3725 |
P05412 |
0.63 |
|
MNDA |
4332 |
P41218 |
0.63 |
|
NTRK1 |
4914 |
P04629 |
0.63 |
|
PPP2R2A |
5520 |
P63151 |
0.63 |
|
MAPK11 |
5600 |
Q15759 |
0.63 |
|
RAD21 |
5885 |
O60216 |
0.63 |
|
RPA1 |
6117 |
P27694 |
0.63 |
|
RPA2 |
6118 |
P15927 |
0.63 |
|
RPA3 |
6119 |
P35244 |
0.63 |
|
SOX2 |
6657 |
P48431 |
0.63 |
|
TERF2 |
7014 |
Q15554 |
0.63 |
|
VCAM1 |
7412 |
P19320 |
0.63 |
|
WHSC1 |
7468 |
O96028 |
0.63 |
|
XPO1 |
7514 |
O14980 |
0.63 |
|
YWHAG |
7532 |
P61981 |
0.63 |
|
CUL3 |
8452 |
Q13618 |
0.63 |
|
CUL1 |
8454 |
Q13616 |
0.63 |
|
EED |
8726 |
O75530 |
0.63 |
|
AIM2 |
9447 |
O14862 |
0.63 |
|
KIAA0101 |
9768 |
Q15004 |
0.63 |
|
COPS5 |
10987 |
Q92905 |
0.63 |
|
GABARAP |
11337 |
O95166 |
0.63 |
|
OBSL1 |
23363 |
O75147 |
0.63 |
|
TARDBP |
23435 |
Q13148 |
0.63 |
|
DROSHA |
29102 |
Q9NRR4 |
0.63 |
|
EXOSC3 |
51010 |
Q9NQT5 |
0.63 |
|
SIRT7 |
51547 |
Q9NRC8 |
0.63 |
|
RBM11 |
54033 |
P57052 |
0.63 |
|
ZCCHC8 |
55596 |
Q6NZY4 |
0.63 |
|
CAND1 |
55832 |
Q86VP6 |
0.63 |
|
UNK |
85451 |
Q9C0B0 |
0.63 |
|
DIS3L |
115752 |
Q8TF46 |
0.63 |
|
BUB1B |
701 |
O60566 |
0.72 |
|
CLK2 |
1196 |
P49760 |
0.72 |
|
GBA |
2629 |
P04062 |
0.72 |
|
HSP90AA1 |
3320 |
P07900 |
0.72 |
|
NCBP1 |
4686 |
Q09161 |
0.72 |
|
PPP2R1A |
5518 |
P30153 |
0.72 |
|
SNCA |
6622 |
P37840 |
0.72 |
|
TAF10 |
6881 |
Q12962 |
0.72 |
|
YWHAB |
7529 |
P31946 |
0.72 |
|
RNPS1 |
10921 |
Q15287 |
0.72 |
|
NCBP2 |
22916 |
P52298 |
0.72 |
|
KIAA1107 |
23285 |
Q9UPP5 |
0.72 |
|
EXOSC1 |
51013 |
Q9Y3B2 |
0.72 |
|
PPP2R2D |
55844 |
Q66LE6 |
0.72 |
|
ZFC3H1 |
196441 |
O60293 |
0.72 |
|
BOD1L1 |
259282 |
Q8NFC6 |
0.72 |
|
MZT1 |
440145 |
Q08AG7 |
0.72 |
|
SUMO2 |
6613 |
P61956 |
0.74 |
|
PPP2R2B |
5521 |
Q00005 |
0.75 |
|
MPHOSPH6 |
10200 |
Q99547 |
0.78 |
|
IFI16 |
3428 |
Q16666 |
0.82 |
|
RBM7 |
10179 |
Q9Y580 |
0.82 |