Protein Description

Gene Symbol SLC35A3
Entrez ID 23443
Uniprot ID Q9Y2D2
Description solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
Chromosomal Location chr1: 99,969,351-100,035,637
Ontology GO ID GO Term Definition Evidence

BP

GO:0006047

UDP-N-acetylglucosamine metabolic process

The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.

TAS

BP

GO:0008643

carbohydrate transport

The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.

IEA

BP

GO:0015788

UDP-N-acetylglucosamine transport

The directed movement of UDP-N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.

IMP

BP

GO:0015992

proton transport

The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

IEA

BP

GO:1990569

UDP-N-acetylglucosamine transmembrane transport

The directed movement of UDP-N-acetylglucosamine across a membrane.

IEA

CC

GO:0000139

Golgi membrane

The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

TAS

CC

GO:0005794

Golgi apparatus

A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.

TAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0005351

sugar:proton symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in).

IEA

MF

GO:0005462

UDP-N-acetylglucosamine transmembrane transporter activity

Enables the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.

TAS

Domain ID Description

IPR007271

Nucleotide-sugar transporter

No pathways found.

No diseases found.

Tissue Cell Type

placenta

decidual cells

rectum

glandular cells

skeletal muscle

myocytes

skin

Langerhans

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

SLC35A3

23443

Q9Y2D2

0.65

TP63

8626

Q9H3D4

0.63

CRADD

8738

P78560

0.63

SLC35A2

7355

P78381

0.73