Protein Description

Gene Symbol CHKB
Entrez ID 1120
Uniprot ID Q9Y259
Description choline kinase beta
Chromosomal Location chr22: 50,578,949-50,601,455
Ontology GO ID GO Term Definition Evidence

BP

GO:0006646

phosphatidylethanolamine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.

IDA|IEA|TAS

BP

GO:0006656

phosphatidylcholine biosynthetic process

The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.

TAS

BP

GO:0006657

CDP-choline pathway

The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine.

IEA

BP

GO:0016310

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

IEA

CC

GO:0005829

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

TAS

MF

GO:0004103

choline kinase activity

Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).

IDA|TAS

MF

GO:0004305

ethanolamine kinase activity

Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.

IDA|TAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

Domain ID Description

IPR011009

Protein kinase-like domain

IPR026712

Choline/Ethanolamine kinase

Pathway ID Pathway Term Pathway Source

hsa00564

Glycerophospholipid metabolism

KEGG

hsa01100

Metabolic pathways

KEGG

hsa05231

Choline metabolism in cancer

KEGG

WP2533

Glycerophospholipid Biosynthetic Pathway

WikiPathways

WP143

Fatty Acid Beta Oxidation

WikiPathways

WP3933

Kennedy pathway

WikiPathways

WP3940

One carbon metabolism and related pathways

WikiPathways

UMLS CUI UMLS Term

C0027404

Narcolepsy

Tissue Cell Type

pancreas

exocrine glandular cells

placenta

decidual cells

placenta

trophoblastic cells

smooth muscle

smooth muscle cells

thyroid gland

glandular cells

tonsil

non-germinal center cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

ALB

213

P02768

0.72