| Gene Symbol | CHKB |
| Entrez ID | 1120 |
| Uniprot ID | Q9Y259 |
| Description | choline kinase beta |
| Chromosomal Location | chr22: 50,578,949-50,601,455 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006646 |
phosphatidylethanolamine biosynthetic process |
The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. |
IDA|IEA|TAS |
|
BP |
GO:0006656 |
phosphatidylcholine biosynthetic process |
The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. |
TAS |
|
BP |
GO:0006657 |
CDP-choline pathway |
The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine. |
IEA |
|
BP |
GO:0016310 |
phosphorylation |
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
IEA |
|
CC |
GO:0005829 |
cytosol |
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
TAS |
|
MF |
GO:0004103 |
choline kinase activity |
Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+). |
IDA|TAS |
|
MF |
GO:0004305 |
ethanolamine kinase activity |
Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine. |
IDA|TAS |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
| Domain ID | Description |
|---|---|
|
IPR011009 |
Protein kinase-like domain |
|
IPR026712 |
Choline/Ethanolamine kinase |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00564 |
Glycerophospholipid metabolism |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa05231 |
Choline metabolism in cancer |
KEGG |
|
WP2533 |
Glycerophospholipid Biosynthetic Pathway |
WikiPathways |
|
WP143 |
Fatty Acid Beta Oxidation |
WikiPathways |
|
WP3933 |
Kennedy pathway |
WikiPathways |
|
WP3940 |
One carbon metabolism and related pathways |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0027404 |
Narcolepsy |
| Tissue | Cell Type |
|---|---|
|
pancreas |
exocrine glandular cells |
|
placenta |
decidual cells |
|
placenta |
trophoblastic cells |
|
smooth muscle |
smooth muscle cells |
|
thyroid gland |
glandular cells |
|
tonsil |
non-germinal center cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
ALB |
213 |
P02768 |
0.72 |