| Gene Symbol | SIK3 |
| Entrez ID | 23387 |
| Uniprot ID | Q9Y2K2 |
| Description | SIK family kinase 3 |
| Chromosomal Location | chr11: 116,843,402-117,098,437 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
BP | GO:0006468 | protein phosphorylation |
The process of introducing a phosphate group on to a protein. | IDA |
BP | GO:0010906 | regulation of glucose metabolic process |
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. | IBA |
CC | GO:0005737 | cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | IBA |
MF | GO:0000287 | magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. | IDA |
MF | GO:0004674 | protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. | IDA |
MF | GO:0005515 | protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). | IPI |
MF | GO:0005524 | ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | IDA |
| Domain ID | Description |
|---|---|
IPR000719 | Protein kinase domain |
IPR008271 | Serine/threonine-protein kinase, active site |
IPR011009 | Protein kinase-like domain |
IPR015940 | Ubiquitin-associated domain |
IPR017441 | Protein kinase, ATP binding site |
IPR034672 | Salt-Inducible kinase, catalytic domain |
| Tissue | Cell Type |
|---|---|
adrenal gland | glandular cells |
appendix | glandular cells |
appendix | lymphoid tissue |
bone marrow | hematopoietic cells |
breast | glandular cells |
breast | myoepithelial cells |
bronchus | respiratory epithelial cells |
caudate | glial cells |
caudate | neuronal cells |
cerebellum | cells in granular layer |
cerebellum | cells in molecular layer |
cerebellum | Purkinje cells |
cerebral cortex | endothelial cells |
cerebral cortex | glial cells |
cerebral cortex | neuronal cells |
cervix, uterine | glandular cells |
cervix, uterine | squamous epithelial cells |
colon | endothelial cells |
colon | glandular cells |
colon | peripheral nerve/ganglion |
duodenum | glandular cells |
endometrium | cells in endometrial stroma |
endometrium | glandular cells |
epididymis | glandular cells |
esophagus | squamous epithelial cells |
fallopian tube | glandular cells |
gallbladder | glandular cells |
heart muscle | myocytes |
hippocampus | glial cells |
hippocampus | neuronal cells |
kidney | cells in glomeruli |
kidney | cells in tubules |
liver | bile duct cells |
liver | hepatocytes |
lung | macrophages |
lung | pneumocytes |
lymph node | germinal center cells |
lymph node | non-germinal center cells |
nasopharynx | respiratory epithelial cells |
oral mucosa | squamous epithelial cells |
ovary | follicle cells |
ovary | ovarian stroma cells |
pancreas | exocrine glandular cells |
pancreas | islets of Langerhans |
parathyroid gland | glandular cells |
placenta | trophoblastic cells |
prostate | glandular cells |
rectum | glandular cells |
salivary gland | glandular cells |
seminal vesicle | glandular cells |
skeletal muscle | myocytes |
skin | fibroblasts |
skin | keratinocytes |
skin | Langerhans |
skin | melanocytes |
skin | epidermal cells |
small intestine | glandular cells |
smooth muscle | smooth muscle cells |
soft tissue | fibroblasts |
spleen | cells in red pulp |
spleen | cells in white pulp |
stomach | glandular cells |
testis | cells in seminiferous ducts |
testis | Leydig cells |
thyroid gland | glandular cells |
tonsil | germinal center cells |
tonsil | non-germinal center cells |
tonsil | squamous epithelial cells |
urinary bladder | urothelial cells |
vagina | squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
22617121 | Ouandaogo et al. | 2012 | Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
22951915 | Haozi et al. | 2012 | Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
HDAC5 | 10014 | Q9UQL6 | 0.52 |
SFN | 2810 | P31947 | 0.63 |
NUP98 | 4928 | P52948 | 0.63 |
MAP3K7 | 6885 | O43318 | 0.63 |
YWHAB | 7529 | P31946 | 0.63 |
YWHAH | 7533 | Q04917 | 0.63 |
YWHAQ | 10971 | P27348 | 0.63 |
TAB2 | 23118 | Q9NYJ8 | 0.63 |
CRTC2 | 200186 | Q53ET0 | 0.71 |
TRIP6 | 7205 | Q15654 | 0.73 |
YWHAE | 7531 | P62258 | 0.82 |
ELAVL1 | 1994 | Q15717 | 0.63 |
PPP3CA | 5530 | Q08209 | 0.63 |
PPP3CC | 5533 | P48454 | 0.63 |
PRKAA1 | 5562 | Q13131 | 0.63 |
TRAF1 | 7185 | Q13077 | 0.63 |
SMAD2 | 4087 | Q15796 | 0.72 |
SMAD3 | 4088 | P84022 | 0.72 |
PRKACA | 5566 | P17612 | 0.73 |
YWHAZ | 7534 | P63104 | 0.87 |