| Gene Symbol | SIK3 |
| Entrez ID | 23387 |
| Uniprot ID | Q9Y2K2 |
| Description | SIK family kinase 3 |
| Chromosomal Location | chr11: 116,843,402-117,098,437 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
IDA |
|
BP |
GO:0010906 |
regulation of glucose metabolic process |
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. |
IBA |
|
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA |
|
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IDA |
|
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IDA |
|
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IDA |
| Domain ID | Description |
|---|---|
|
IPR000719 |
Protein kinase domain |
|
IPR008271 |
Serine/threonine-protein kinase, active site |
|
IPR011009 |
Protein kinase-like domain |
|
IPR015940 |
Ubiquitin-associated domain |
|
IPR017441 |
Protein kinase, ATP binding site |
|
IPR034672 |
Salt-Inducible kinase, catalytic domain |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
appendix |
glandular cells |
|
appendix |
lymphoid tissue |
|
bone marrow |
hematopoietic cells |
|
breast |
glandular cells |
|
breast |
myoepithelial cells |
|
bronchus |
respiratory epithelial cells |
|
caudate |
glial cells |
|
caudate |
neuronal cells |
|
cerebellum |
cells in granular layer |
|
cerebellum |
cells in molecular layer |
|
cerebellum |
Purkinje cells |
|
cerebral cortex |
endothelial cells |
|
cerebral cortex |
glial cells |
|
cerebral cortex |
neuronal cells |
|
cervix, uterine |
glandular cells |
|
cervix, uterine |
squamous epithelial cells |
|
colon |
endothelial cells |
|
colon |
glandular cells |
|
colon |
peripheral nerve/ganglion |
|
duodenum |
glandular cells |
|
endometrium |
cells in endometrial stroma |
|
endometrium |
glandular cells |
|
epididymis |
glandular cells |
|
esophagus |
squamous epithelial cells |
|
fallopian tube |
glandular cells |
|
gallbladder |
glandular cells |
|
heart muscle |
myocytes |
|
hippocampus |
glial cells |
|
hippocampus |
neuronal cells |
|
kidney |
cells in glomeruli |
|
kidney |
cells in tubules |
|
liver |
bile duct cells |
|
liver |
hepatocytes |
|
lung |
macrophages |
|
lung |
pneumocytes |
|
lymph node |
germinal center cells |
|
lymph node |
non-germinal center cells |
|
nasopharynx |
respiratory epithelial cells |
|
oral mucosa |
squamous epithelial cells |
|
ovary |
follicle cells |
|
ovary |
ovarian stroma cells |
|
pancreas |
exocrine glandular cells |
|
pancreas |
islets of Langerhans |
|
parathyroid gland |
glandular cells |
|
placenta |
trophoblastic cells |
|
prostate |
glandular cells |
|
rectum |
glandular cells |
|
salivary gland |
glandular cells |
|
seminal vesicle |
glandular cells |
|
skeletal muscle |
myocytes |
|
skin |
fibroblasts |
|
skin |
keratinocytes |
|
skin |
Langerhans |
|
skin |
melanocytes |
|
skin |
epidermal cells |
|
small intestine |
glandular cells |
|
smooth muscle |
smooth muscle cells |
|
soft tissue |
fibroblasts |
|
spleen |
cells in red pulp |
|
spleen |
cells in white pulp |
|
stomach |
glandular cells |
|
testis |
cells in seminiferous ducts |
|
testis |
Leydig cells |
|
thyroid gland |
glandular cells |
|
tonsil |
germinal center cells |
|
tonsil |
non-germinal center cells |
|
tonsil |
squamous epithelial cells |
|
urinary bladder |
urothelial cells |
|
vagina |
squamous epithelial cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
HDAC5 |
10014 |
Q9UQL6 |
0.52 |
|
SFN |
2810 |
P31947 |
0.63 |
|
NUP98 |
4928 |
P52948 |
0.63 |
|
MAP3K7 |
6885 |
O43318 |
0.63 |
|
YWHAB |
7529 |
P31946 |
0.63 |
|
YWHAH |
7533 |
Q04917 |
0.63 |
|
YWHAQ |
10971 |
P27348 |
0.63 |
|
TAB2 |
23118 |
Q9NYJ8 |
0.63 |
|
CRTC2 |
200186 |
Q53ET0 |
0.71 |
|
TRIP6 |
7205 |
Q15654 |
0.73 |
|
YWHAE |
7531 |
P62258 |
0.82 |
|
ELAVL1 |
1994 |
Q15717 |
0.63 |
|
PPP3CA |
5530 |
Q08209 |
0.63 |
|
PPP3CC |
5533 |
P48454 |
0.63 |
|
PRKAA1 |
5562 |
Q13131 |
0.63 |
|
TRAF1 |
7185 |
Q13077 |
0.63 |
|
SMAD2 |
4087 |
Q15796 |
0.72 |
|
SMAD3 |
4088 |
P84022 |
0.72 |
|
PRKACA |
5566 |
P17612 |
0.73 |
|
YWHAZ |
7534 |
P63104 |
0.87 |