Protein Description

Gene Symbol PUM2
Entrez ID 23369
Uniprot ID Q8TB72
Description pumilio RNA binding family member 2
Chromosomal Location chr2: 20,248,691-20,352,234
Ontology GO ID GO Term Definition Evidence

BP

GO:0010608

posttranscriptional regulation of gene expression

Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.

IDA

BP

GO:0034063

stress granule assembly

The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.

IEA

BP

GO:0043488

regulation of mRNA stability

Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.

IDA

BP

GO:0051983

regulation of chromosome segregation

Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

IDA

BP

GO:0060964

regulation of gene silencing by miRNA

Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.

TAS

BP

GO:1900246

positive regulation of RIG-I signaling pathway

Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway.

IDA

BP

GO:2000637

positive regulation of gene silencing by miRNA

Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.

IMP

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IDA

CC

GO:0010494

cytoplasmic stress granule

A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.

IDA|ISS

CC

GO:0031965

nuclear membrane

Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

IDA

CC

GO:0048471

perinuclear region of cytoplasm

Cytoplasm situated near, or occurring around, the nucleus.

IDA

MF

GO:0003723

RNA binding

Interacting selectively and non-covalently with an RNA molecule or a portion thereof.

IDA

MF

GO:0003730

mRNA 3'-UTR binding

Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.

IDA

MF

GO:0005515

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

IPI

MF

GO:0044822

poly(A) RNA binding

Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases.

IDA

Domain ID Description

IPR001313

Pumilio RNA-binding repeat

IPR011989

Armadillo-like helical

IPR016024

Armadillo-type fold

IPR033133

Pumilio homology domain

IPR033712

Pumilio, RNA binding domain

No pathways found.

No diseases found.

Tissue Cell Type

appendix

glandular cells

colon

glandular cells

esophagus

squamous epithelial cells

gallbladder

glandular cells

heart muscle

myocytes

kidney

cells in tubules

parathyroid gland

glandular cells

rectum

glandular cells

skeletal muscle

myocytes

small intestine

glandular cells

stomach

glandular cells

No databases found.

Pubmed ID Author Year Title

22951915

Haozi et al.

2012

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

Gene Symbol Entrez ID Uniprot ID Score

MED23

9439

Q9ULK4

0.63

PUM2

23369

Q8TB72

0.63

NANOS3

342977

P60323

0.63

DAZL

1618

Q92904

0.67

NOS1

4842

P29475

0.72

ATP1A3

478

P13637

0.63

BMI1

648

P35226

0.63

ELAVL1

1994

Q15717

0.63

ILF2

3608

Q12905

0.63

NTRK1

4914

P04629

0.63

ATG5

9474

Q9H1Y0

0.63

PDLIM5

10611

Q96HC4

0.63

SNW1

22938

Q13573

0.63

RBFOX2

23543

O43251

0.63

MED4

29079

Q9NPJ6

0.63

DAZ3

57054

Q9NR90

0.65

DAZ4

57135

Q86SG3

0.65

AURKA

6790

O14965

0.68

SAMD1

90378

Q6SPF0

0.72

RBM45

129831

Q8IUH3

0.72

NANOS1

340719

Q8WY41

0.74

DAZ1

1617

Q9NQZ3

0.77