Gene Symbol | PUM2 |
Entrez ID | 23369 |
Uniprot ID | Q8TB72 |
Description | pumilio RNA binding family member 2 |
Chromosomal Location | chr2: 20,248,691-20,352,234 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0010608 |
posttranscriptional regulation of gene expression |
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. |
IDA |
BP |
GO:0034063 |
stress granule assembly |
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. |
IEA |
BP |
GO:0043488 |
regulation of mRNA stability |
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs. |
IDA |
BP |
GO:0051983 |
regulation of chromosome segregation |
Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets. |
IDA |
BP |
GO:0060964 |
regulation of gene silencing by miRNA |
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression. |
TAS |
BP |
GO:1900246 |
positive regulation of RIG-I signaling pathway |
Any process that activates or increases the frequency, rate or extent of RIG-I signaling pathway. |
IDA |
BP |
GO:2000637 |
positive regulation of gene silencing by miRNA |
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA. |
IMP |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IDA |
CC |
GO:0010494 |
cytoplasmic stress granule |
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
IDA|ISS |
CC |
GO:0031965 |
nuclear membrane |
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
IDA |
CC |
GO:0048471 |
perinuclear region of cytoplasm |
Cytoplasm situated near, or occurring around, the nucleus. |
IDA |
MF |
GO:0003723 |
RNA binding |
Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
IDA |
MF |
GO:0003730 |
mRNA 3'-UTR binding |
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule. |
IDA |
MF |
GO:0005515 |
protein binding |
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
IPI |
MF |
GO:0044822 |
poly(A) RNA binding |
Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases. |
IDA |
Domain ID | Description |
---|---|
IPR001313 |
Pumilio RNA-binding repeat |
IPR011989 |
Armadillo-like helical |
IPR016024 |
Armadillo-type fold |
IPR033133 |
Pumilio homology domain |
IPR033712 |
Pumilio, RNA binding domain |
Tissue | Cell Type |
---|---|
appendix |
glandular cells |
colon |
glandular cells |
esophagus |
squamous epithelial cells |
gallbladder |
glandular cells |
heart muscle |
myocytes |
kidney |
cells in tubules |
parathyroid gland |
glandular cells |
rectum |
glandular cells |
skeletal muscle |
myocytes |
small intestine |
glandular cells |
stomach |
glandular cells |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22951915 |
Haozi et al. |
2012 |
Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
MED23 |
9439 |
Q9ULK4 |
0.63 |
PUM2 |
23369 |
Q8TB72 |
0.63 |
NANOS3 |
342977 |
P60323 |
0.63 |
DAZL |
1618 |
Q92904 |
0.67 |
NOS1 |
4842 |
P29475 |
0.72 |
ATP1A3 |
478 |
P13637 |
0.63 |
BMI1 |
648 |
P35226 |
0.63 |
ELAVL1 |
1994 |
Q15717 |
0.63 |
ILF2 |
3608 |
Q12905 |
0.63 |
NTRK1 |
4914 |
P04629 |
0.63 |
ATG5 |
9474 |
Q9H1Y0 |
0.63 |
PDLIM5 |
10611 |
Q96HC4 |
0.63 |
SNW1 |
22938 |
Q13573 |
0.63 |
RBFOX2 |
23543 |
O43251 |
0.63 |
MED4 |
29079 |
Q9NPJ6 |
0.63 |
DAZ3 |
57054 |
Q9NR90 |
0.65 |
DAZ4 |
57135 |
Q86SG3 |
0.65 |
AURKA |
6790 |
O14965 |
0.68 |
SAMD1 |
90378 |
Q6SPF0 |
0.72 |
RBM45 |
129831 |
Q8IUH3 |
0.72 |
NANOS1 |
340719 |
Q8WY41 |
0.74 |
DAZ1 |
1617 |
Q9NQZ3 |
0.77 |