Protein Description

Gene Symbol ACSL6
Entrez ID 23305
Uniprot ID Q9UKU0
Description Long-chain-fatty-acid--CoA ligase 6
Chromosomal Location chr5: 131,949,973-132,012,243
Ontology GO ID GO Term Definition Evidence

BP

GO:0001676

long-chain fatty acid metabolic process

The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

IEA

BP

GO:0006637

acyl-CoA metabolic process

The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group.

NAS

BP

GO:0035338

long-chain fatty-acyl-CoA biosynthetic process

The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.

TAS

CC

GO:0005741

mitochondrial outer membrane

The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.

IEA

CC

GO:0005778

peroxisomal membrane

The lipid bilayer surrounding a peroxisome.

IEA

CC

GO:0005789

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

TAS

CC

GO:0005886

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

NAS

CC

GO:0016021

integral component of membrane

The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

IEA

MF

GO:0004467

long-chain fatty acid-CoA ligase activity

Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

NAS|TAS

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IEA

MF

GO:0042803

protein homodimerization activity

Interacting selectively and non-covalently with an identical protein to form a homodimer.

IDA

MF

GO:0102391

decanoate--CoA ligase activity

Catalysis of the reaction: decanoate + ATP(4-) + coenzyme A(4-) <=> decanoyl-CoA(4-) + AMP(2-) + diphosphoric acid

IEA

Domain ID Description

IPR000873

AMP-dependent synthetase/ligase

IPR020845

AMP-binding, conserved site

Pathway ID Pathway Term Pathway Source

hsa00061

Fatty acid biosynthesis

KEGG

hsa00071

Fatty acid degradation

KEGG

hsa01100

Metabolic pathways

KEGG

hsa01212

Fatty acid metabolism

KEGG

hsa03320

PPAR signaling pathway

KEGG

hsa04146

Peroxisome

KEGG

hsa04920

Adipocytokine signaling pathway

KEGG

WP357

Fatty Acid Biosynthesis

WikiPathways

WP3942

PPAR signaling pathway

WikiPathways

WP143

Fatty Acid Beta Oxidation

WikiPathways

UMLS CUI UMLS Term

C0236733

Amphetamine-Related Disorders

Tissue Cell Type

adrenal gland

glandular cells

cerebellum

Purkinje cells

colon

glandular cells

duodenum

glandular cells

gallbladder

glandular cells

lung

macrophages

oral mucosa

squamous epithelial cells

pancreas

exocrine glandular cells

seminal vesicle

glandular cells

small intestine

glandular cells

stomach

glandular cells

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CPT1A

1374

P50416

0.00

PPARA

5465

Q07869

0.00

PHYH

5264

O14832

0.59

FLNC

2318

Q14315

0.63

ZNF16

7564

P17020

0.63

ACSL6

23305

Q9UKU0

0.78