| Gene Symbol | ACSL6 |
| Entrez ID | 23305 |
| Uniprot ID | Q9UKU0 |
| Description | Long-chain-fatty-acid--CoA ligase 6 |
| Chromosomal Location | chr5: 131,949,973-132,012,243 |
| Ontology | GO ID | GO Term | Definition | Evidence |
|---|---|---|---|---|
|
BP |
GO:0001676 |
long-chain fatty acid metabolic process |
The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
IEA |
|
BP |
GO:0006637 |
acyl-CoA metabolic process |
The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. |
NAS |
|
BP |
GO:0035338 |
long-chain fatty-acyl-CoA biosynthetic process |
The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more. |
TAS |
|
CC |
GO:0005741 |
mitochondrial outer membrane |
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
IEA |
|
CC |
GO:0005778 |
peroxisomal membrane |
The lipid bilayer surrounding a peroxisome. |
IEA |
|
CC |
GO:0005789 |
endoplasmic reticulum membrane |
The lipid bilayer surrounding the endoplasmic reticulum. |
TAS |
|
CC |
GO:0005886 |
plasma membrane |
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
NAS |
|
CC |
GO:0016021 |
integral component of membrane |
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
IEA |
|
MF |
GO:0004467 |
long-chain fatty acid-CoA ligase activity |
Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22. |
NAS|TAS |
|
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IEA |
|
MF |
GO:0042803 |
protein homodimerization activity |
Interacting selectively and non-covalently with an identical protein to form a homodimer. |
IDA |
|
MF |
GO:0102391 |
decanoate--CoA ligase activity |
Catalysis of the reaction: decanoate + ATP(4-) + coenzyme A(4-) <=> decanoyl-CoA(4-) + AMP(2-) + diphosphoric acid |
IEA |
| Domain ID | Description |
|---|---|
|
IPR000873 |
AMP-dependent synthetase/ligase |
|
IPR020845 |
AMP-binding, conserved site |
| Pathway ID | Pathway Term | Pathway Source |
|---|---|---|
|
hsa00061 |
Fatty acid biosynthesis |
KEGG |
|
hsa00071 |
Fatty acid degradation |
KEGG |
|
hsa01100 |
Metabolic pathways |
KEGG |
|
hsa01212 |
Fatty acid metabolism |
KEGG |
|
hsa03320 |
PPAR signaling pathway |
KEGG |
|
hsa04146 |
Peroxisome |
KEGG |
|
hsa04920 |
Adipocytokine signaling pathway |
KEGG |
|
WP357 |
Fatty Acid Biosynthesis |
WikiPathways |
|
WP3942 |
PPAR signaling pathway |
WikiPathways |
|
WP143 |
Fatty Acid Beta Oxidation |
WikiPathways |
| UMLS CUI | UMLS Term |
|---|---|
|
C0236733 |
Amphetamine-Related Disorders |
| Tissue | Cell Type |
|---|---|
|
adrenal gland |
glandular cells |
|
cerebellum |
Purkinje cells |
|
colon |
glandular cells |
|
duodenum |
glandular cells |
|
gallbladder |
glandular cells |
|
lung |
macrophages |
|
oral mucosa |
squamous epithelial cells |
|
pancreas |
exocrine glandular cells |
|
seminal vesicle |
glandular cells |
|
small intestine |
glandular cells |
|
stomach |
glandular cells |
| Pubmed ID | Author | Year | Title |
|---|---|---|---|
|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
| Gene Symbol | Entrez ID | Uniprot ID | Score |
|---|---|---|---|
|
CPT1A |
1374 |
P50416 |
0.00 |
|
PPARA |
5465 |
Q07869 |
0.00 |
|
PHYH |
5264 |
O14832 |
0.59 |
|
FLNC |
2318 |
Q14315 |
0.63 |
|
ZNF16 |
7564 |
P17020 |
0.63 |
|
ACSL6 |
23305 |
Q9UKU0 |
0.78 |