Protein Description

Gene Symbol SIK2
Entrez ID 23235
Uniprot ID Q9H0K1
Description salt inducible kinase 2
Chromosomal Location chr11: 111,602,391-111,730,853
Ontology GO ID GO Term Definition Evidence

BP

GO:0006468

protein phosphorylation

The process of introducing a phosphate group on to a protein.

IDA

BP

GO:0032870

cellular response to hormone stimulus

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.

IBA

BP

GO:0035556

intracellular signal transduction

The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

IDA

BP

GO:0046626

regulation of insulin receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin receptor signaling.

ISS

BP

GO:0046777

protein autophosphorylation

The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).

IDA

CC

GO:0005634

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

IBA

CC

GO:0005737

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

IBA|ISS

MF

GO:0000287

magnesium ion binding

Interacting selectively and non-covalently with magnesium (Mg) ions.

IDA

MF

GO:0004674

protein serine/threonine kinase activity

Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

IDA

MF

GO:0005524

ATP binding

Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

IDA

Domain ID Description

IPR000719

Protein kinase domain

IPR008271

Serine/threonine-protein kinase, active site

IPR011009

Protein kinase-like domain

IPR015940

Ubiquitin-associated domain

IPR017090

Serine/threonine-protein kinase, SIK1/2

IPR017441

Protein kinase, ATP binding site

IPR034672

Salt-Inducible kinase, catalytic domain

Pathway ID Pathway Term Pathway Source

hsa04922

Glucagon signaling pathway

KEGG

No diseases found.

No tissues found.

No databases found.

Pubmed ID Author Year Title

22617121

Ouandaogo et al.

2012

Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation

Gene Symbol Entrez ID Uniprot ID Score

CETN3

1070

O15182

0.52

IRS1

3667

P35568

0.55

APP

351

P05067

0.56

HDAC5

10014

Q9UQL6

0.62

HSPA4

3308

P34932

0.63

PPP2R1A

5518

P30153

0.63

PPP2R1B

5519

P30154

0.63

PPP2R2A

5520

P63151

0.63

YWHAZ

7534

P63104

0.63

CSNK1A1

1452

P48729

0.72

EMD

2010

P50402

0.72

FUS

2521

P35637

0.72

HSPA2

3306

P54652

0.72

HSPB1

3315

P04792

0.72

SLC25A1

6576

P53007

0.72

TUBA4A

7277

P68366

0.72

BAG2

9532

O95816

0.72

TRIM28

10155

Q13263

0.72

SLC25A13

10165

Q9UJS0

0.72

SHROOM3

57619

Q8TF72

0.72

PPP2CA

5515

P67775

0.82

YWHAE

7531

P62258

0.82

VCP

7415

P55072

0.86

CRTC2

200186

Q53ET0

0.87

ILK

3611

Q13418

0.63

PRKAA1

5562

Q13131

0.63

XPO1

7514

O14980

0.63

YWHAQ

10971

P27348

0.63

GABARAPL2

11345

P60520

0.63

FBXW11

23291

Q9UKB1

0.63

PPP2R2B

5521

Q00005

0.68

PPP2R2C

5522

Q9Y2T4

0.73

CEP250

11190

Q9BV73

0.78