Gene Symbol | SIK2 |
Entrez ID | 23235 |
Uniprot ID | Q9H0K1 |
Description | salt inducible kinase 2 |
Chromosomal Location | chr11: 111,602,391-111,730,853 |
Ontology | GO ID | GO Term | Definition | Evidence |
---|---|---|---|---|
BP |
GO:0006468 |
protein phosphorylation |
The process of introducing a phosphate group on to a protein. |
IDA |
BP |
GO:0032870 |
cellular response to hormone stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. |
IBA |
BP |
GO:0035556 |
intracellular signal transduction |
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
IDA |
BP |
GO:0046626 |
regulation of insulin receptor signaling pathway |
Any process that modulates the frequency, rate or extent of insulin receptor signaling. |
ISS |
BP |
GO:0046777 |
protein autophosphorylation |
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
IDA |
CC |
GO:0005634 |
nucleus |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
IBA |
CC |
GO:0005737 |
cytoplasm |
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
IBA|ISS |
MF |
GO:0000287 |
magnesium ion binding |
Interacting selectively and non-covalently with magnesium (Mg) ions. |
IDA |
MF |
GO:0004674 |
protein serine/threonine kinase activity |
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. |
IDA |
MF |
GO:0005524 |
ATP binding |
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
IDA |
Domain ID | Description |
---|---|
IPR000719 |
Protein kinase domain |
IPR008271 |
Serine/threonine-protein kinase, active site |
IPR011009 |
Protein kinase-like domain |
IPR015940 |
Ubiquitin-associated domain |
IPR017090 |
Serine/threonine-protein kinase, SIK1/2 |
IPR017441 |
Protein kinase, ATP binding site |
IPR034672 |
Salt-Inducible kinase, catalytic domain |
Pathway ID | Pathway Term | Pathway Source |
---|---|---|
hsa04922 |
Glucagon signaling pathway |
KEGG |
Pubmed ID | Author | Year | Title |
---|---|---|---|
22617121 |
Ouandaogo et al. |
2012 |
Differences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo andin vitro oocyte maturation |
Gene Symbol | Entrez ID | Uniprot ID | Score |
---|---|---|---|
CETN3 |
1070 |
O15182 |
0.52 |
IRS1 |
3667 |
P35568 |
0.55 |
APP |
351 |
P05067 |
0.56 |
HDAC5 |
10014 |
Q9UQL6 |
0.62 |
HSPA4 |
3308 |
P34932 |
0.63 |
PPP2R1A |
5518 |
P30153 |
0.63 |
PPP2R1B |
5519 |
P30154 |
0.63 |
PPP2R2A |
5520 |
P63151 |
0.63 |
YWHAZ |
7534 |
P63104 |
0.63 |
CSNK1A1 |
1452 |
P48729 |
0.72 |
EMD |
2010 |
P50402 |
0.72 |
FUS |
2521 |
P35637 |
0.72 |
HSPA2 |
3306 |
P54652 |
0.72 |
HSPB1 |
3315 |
P04792 |
0.72 |
SLC25A1 |
6576 |
P53007 |
0.72 |
TUBA4A |
7277 |
P68366 |
0.72 |
BAG2 |
9532 |
O95816 |
0.72 |
TRIM28 |
10155 |
Q13263 |
0.72 |
SLC25A13 |
10165 |
Q9UJS0 |
0.72 |
SHROOM3 |
57619 |
Q8TF72 |
0.72 |
PPP2CA |
5515 |
P67775 |
0.82 |
YWHAE |
7531 |
P62258 |
0.82 |
VCP |
7415 |
P55072 |
0.86 |
CRTC2 |
200186 |
Q53ET0 |
0.87 |
ILK |
3611 |
Q13418 |
0.63 |
PRKAA1 |
5562 |
Q13131 |
0.63 |
XPO1 |
7514 |
O14980 |
0.63 |
YWHAQ |
10971 |
P27348 |
0.63 |
GABARAPL2 |
11345 |
P60520 |
0.63 |
FBXW11 |
23291 |
Q9UKB1 |
0.63 |
PPP2R2B |
5521 |
Q00005 |
0.68 |
PPP2R2C |
5522 |
Q9Y2T4 |
0.73 |
CEP250 |
11190 |
Q9BV73 |
0.78 |